IBT-UNAM : Dr. Alejandro Alagon Cano
Dr. Alejandro Alagon Cano Grupo
Departamento de Medicina Molecular y Bioprocesos
Líneas de investigación
email: alagon @ibt.unam.mx
Teléfonos
Oficina +52 (777) 329-1649 red UNAM 27649 +52 (777) 311-4900 ext 294 Laboratorio +52 (777) 329-1602 red UNAM 27602 +52 (777) 311-4900 ext 294
- Licenciatura: Medico Cirujano, Fac. de Medicina, UNAM (1978)
Premio Luis Elizondo al sentido humano 2013, Sistema Tecnológico de Monterrey (2013) Premio Nacional de Ciencias y Artes Gobierno de la República (2005) Premio UNAM 2004 Innovación Tecnológica (2004)
Estudiantes M.V.Z. Oscar Aguayo
Biol. Olivia Yelisseth Vazquez
Maria Fernanda Hernandez
M.C. Melisa Benard
Oscar Germán Jiménez
C.D. José Roberto Ponce
Q.F.B. Raul Roman Flores "Desarrollo y optimización de un método analítico tipo ELISA para la cuantificación de componentes de bajo peso molecular del veneno de Micrurus fulvius en plasma y linfa ovino"
Ing. Irene María Castillo
Biol. Luis Roman
M.B. Edgar Enrique Neri
Belem Garcia
Manuel Francisco Yañez
Sergio Barcenas
Publicaciones recientes
Hernandez-Vargas,M.J. Gil,J. Lozano,L. Pedraza-Escalona,M. Ortiz,E. Encarnacion-Guevara,S. Alagon,A. Corzo,G.
2017. Proteomic and transcriptomic analysis of saliva components from the hematophagous reduviid Triatoma pallidipennis Journal of Proteomics, 162, 30-39.
de la Rosa G. Pastor,N. Alagon,A. Corzo,G.
2017. Synthetic peptide antigens derived from long-chain alpha-neurotoxins: Immunogenicity effect against elapid venoms Peptides, 88, 80-86.
Lomonte,B. Rey-Suarez,P. Fernandez,J. Sasa,M. Pla,D. Vargas,N. Benard-Valle,M. Sanz,L. Correa-Netto,C. Nunez,V. Alape-Giron,A. Alagon,A. Gutierrez,J.M. Calvete,J.J.
2016. Venoms of Micrurus coral snakes: Evolutionary trends in compositional patterns emerging from proteomic analyses Toxicon, 122, 7-25.
Clement,H. Flores,V. de la Rosa,G. Zamudio,F. Alagon,A. Corzo,G.
2016. Heterologous expression, protein folding and antibody recognition of a neurotoxin from the Mexican coral snake Micrurus laticorallis Journal of Venomous Animals and Toxins Including Tropical Diseases, 22, 25.
Olvera,F. Rosales,A. Olvera,A. Diaz,P. Sevcik,C. Salazar,V. Alagon,A. Hernandez,H. D'Suze,G.
2016. An efficient approach to clone and express active Neopladine 2, an anticancer peptide from Tityus discrepans scorpion venom Process Biochemistry, 51, 624-631.
Vergara,I. Castillo,E.Y. Romero-Pina,M.E. Torres-Viquez,I. Paniagua,D. Boyer,L.V. Alagon,A. Medina,L.A.
2016. Biodistribution and Lymphatic Tracking of the Main Neurotoxin of Micrurus fulvius Venom by Molecular Imaging Toxins (Basel), 8, .
Chippaux,J.P. Boyer,L.V. Alagon,A.
2015. Post-exposure treatment of Ebola virus using passive immunotherapy: proposal for a new strategy Journal of Venomous Animals and Toxins Including Tropical Diseases, 21, 3.
Bush,S.P. Ruha,A.M. Seifert,S.A. Morgan,D.L. Lewis,B.J. Arnold,T.C. Clark,R.F. Meggs,W.J. Toschlog,E.A. Borron,S.W. Figge,G.R. Sollee,D.R. Shirazi,F.M. Wolk,R. de Chazal,I. Quan,D. Garcia-Ubbelohde,W. Alagon,A. Gerkin,R.D. Boyer,L.V.
2015. Comparison of F(ab') versus Fab antivenom for pit viper envenomation: A prospective, blinded, multicenter, randomized clinical trial Clinical Toxicology, 53, 37-45.
Sanchez-Villegas,M.d.C. Nazario-Santiago,C. Alagon-Cano,A. Merquez-Avila,G. Ramos-Cervantes,M.T. Loria-Castellanos,J.
2014. Cunico-epidemiological characteristics of pediatric patients with poisoning by loxosceles spiders bite.Prensa Medica Argentina, 100, 605-613.
Castellanos-Mendoza,A. Castro-Acosta,R.M. Olvera,A. Zavala,G. Mendoza-Vera,M. Garcia-Hernandez,E. Alagon,A. Trujillo-Roldan,M.A. Valdez-Cruz,N.A.
2014. Influence of pH control in the formation of inclusion bodies during production of recombinant sphingomyelinase-D in Escherichia coli Microbial Cell Factories, 13, 137.
Diaz,P. Malave,C. Zerpa,N. Vazquez,H. D'Suze,G. Montero,Y. Castillo,C. Alagon,A. Sevcik,C.
2014. IgY pharmacokinetics in rabbits: Implications for IgY use as antivenoms Toxicon, 90, 124-133.
de Roodt,A.R. Clement,H. Dolab,J.A. Litwin,S. Hajos,S.E. Boyer,L. Alagon,A.
2014. Protein content of antivenoms and relationship with their immunochemical reactivity and neutralization assays Clinical Toxicology, 52, 594-603.
Borja,M. Castaneda,G. Espinosa,J. Neri,E. Carbajal,A. Clement,H. Garcia,O. Alagon,A.
2014. Mojave Rattlesnake (Crotalus scutulatus scutulatus) with Type B Venom from Mexico Copeia, 2014, 7-13.
Lanari,L.C. Olvera,A. Costa de Oliveira,V. Laskowicz,R.D. Boyer,L. Lago,N.R. Alagon,A. de Roodt,A.R.
2014. Intraspecific differences in the immunochemical reactivity and neutralization of venom from Argentinean Bothrops (Rhinocerophis) alternatus by specific experimental antivenoms Toxicon, 85, 31-45 [corrigendum vol 88 p 138].
Vergara,I. Pedraza-Escalona,M. Paniagua,D. Restano-Cassulini,R. Zamudio,F. Batista,C.V. Possani,L.D. Alagon,A.
2014. Eastern coral snake Micrurus fulvius venom toxicity in mice is mainly determined by neurotoxic phospholipases A Journal of Proteomics, 105, 295-306.
Carbajal-Saucedo,A. Floriano,R.S. Belo,C.A. Olvera-Rodriguez,A. Alagon,A. Rodrigues-Simioni,L.
2014. Neuromuscular Activity of Micrurus laticollaris (Squamata: Elapidae) Venom in Vitro Toxins (Basel), 6, 359-370.
Benard-Valle,M. Carbajal-Saucedo,A. de Roodt,A. Lopez-Vera,E. Alagon,A.
2014. Biochemical characterization of the venom of the coral snake Micrurus tener and comparative biological activities in the mouse and a reptile model Toxicon, 77, 6-15.
Oukkache,N. Chgoury,F. Lalaoui,M. Alagon-Cano,A. Ghalim,N.
2013. Comparison between two methods of scorpion venom milking in Morocco Journal of Venomous Animals and Toxins Including Tropical Diseases, 19, 5.
Vazquez,H. Olvera,F. Alagon,A. Sevcik,C.
2013. Production of anti-horse antibodies induced by IgG, F(ab') and Fab applied repeatedly to rabbits. Effect on antivenom pharmacokinetics Toxicon, 76, 362-369.
Boyer,L.V. Chase,P.B. Degan,J.A. Figge,G. Buelna-Romero,A. Luchetti,C. Alagon,A.
2013. Subacute coagulopathy in a randomized, comparative trial of Fab and F(ab') antivenoms Toxicon, 74, 101-108.
Boyer,L. Degan,J. Ruha,A.M. Mallie,J. Mangin,E. Alagon,A.
2013. Safety of Intravenous Equine F(ab'): Insights following Clinical Trials involving 1534 Recipients of Scorpion Antivenom Toxicon, 76, 386-393.
Boyer,L.V. Theodorou,A.T. Chase,P.B. Osnaya,N. Berg,M. Mallie,J. Carbajal,Y. de Jesus-Hernandez,T. Olvera,F. Alagon,A.
2013. Effectiveness of Centruroides scorpion antivenom compared to historical controls Toxicon, 76, 377-385.
Low,D.H. Sunagar,K. Undheim,E.A. Ali,S.A. Alagon,A.C. Ruder,T. Jackson,T.N. Pineda-Gonzalez,S. King,G.F. Jones,A. Antunes,A. Fry,B.G.
2013. Dracula's children: Molecular evolution of vampire bat venom Journal of Proteomics, 89C, 95-111.
Neri-Castro,E. Lomonte,B. Gutierrez,M.C. Alagon,A. Gutierrez,J.M.
2013. Intraspecies variation in the venom of the rattlesnake Crotalus simus from Mexico: Different expression of crotoxin results in highly variable toxicity in the venoms of three subspecies Journal of Proteomics, 87, 103-121.
Paniagua,D. Jimenez,L. Romero,C. Vergara,I. Calderon,A. Benard,M. Bernas,M.J. Rilo,H. de Roodt,A. D'Suze,G. Witte,M.H. Boyer,L. Alagon,A.
2012. Lymphatic route of transport and pharmacokinetics of Micrurus fulvius (coral snake) venom in sheep Lymphology, 45, 144-153.
Koludarov,I. Sunagar,K. Undheim,E.A. Jackson,T.N. Ruder,T. Whitehead,D. Saucedo,A.C. Mora,G.R. Alagon,A.C. King,G. Antunes,A. Fry,B.G.
2012. Structural and Molecular Diversification of the Anguimorpha Lizard Mandibular Venom Gland System in the Arboreal Species Abronia graminea Journal of Molecular Evolution, 75, 168-183.
Clement,H. Olvera,A. Rodriguez,M. Zamudio,F. Palomares,L.A. Possani,L.D. Odell,G.V. Alagon,A. Sanchez-Lopez,R.
2012. Identification, cDNA cloning and heterologous expression of a hyaluronidase from the tarantula Brachypelma vagans venom Toxicon, 60, 1223-1227.
Clement,H. Costa de Oliveira,V. Zamudio,F.Z. Lago,N.R. Valdez-Cruz,N.A. Valle,M.B. Alagon,A.C. Possani,L.D. de Roodt,A.R.
2012. Isolation, amino acid sequence and biological characterization of an "aspartic-49" phospholipase A(2) from Bothrops (Rhinocerophis) ammodytoides Venom Toxicon, 60, 1314-1323.
Archundia,I.G. de Roodt,A.R. Ramos-Cerrillo,B. Chippaux,J.P. Olguin-Perez,L. Alagon,A. Stock,R.P.
2011. Neutralization of Vipera and Macrovipera venoms by two experimental polyvalent antisera: A study of paraspecificity Toxicon, 57, 1049-1056.
Vazquez,H. Chavez-Haro,A. Garcia-Ubbelohde,W. Paniagua-Solis,J. Alagon,A. Sevcik,C.
2010. Pharmacokinetics of a F(ab')(2) scorpion antivenom administered intramuscularly in healthy human volunteers International Immunopharmacology, 10, 1318-1324.
Vazquez,H. Olvera,F. Paniagua-Solis,J. Alagon,A. Sevcik,C.
2010. Pharmacokinetics in rabbits and anti-sphingomyelinase D neutralizing power of Fab, F(ab')2, IgG and IgG(T) fragments from hyper immune equine plasma International Immunopharmacology, 10, 447-454.
Redaelli,E. Restano-Cassulini,R. Fuentes-Silva,D. Clement,H. Schiavon,E. Zamudio,F.Z. Odell,G. Arcangeli,A. Clare,J.J. Alagon,A. Rodriguez de la Vega,R.C. Possani,L.D. Wanke,E.
2010. Target promiscuity and heterogeneous effects of tarantula venom peptides affecting Na+ and K+ ion channels Journal of Biological Chemistry, 285, 4130-4142 (Correction vol 285 (17) pp 13314-13314).
Boyer,L.V. Theodorou,A.A. Berg,R.A. Mallie,J. Chavez-Mendez,A. Garcia-Ubbelohde,W. Hardiman,S. Alagon,A.
2009. Antivenom for critically ill children with neurotoxicity from scorpion stings New England Journal of Medicine, 360, 2090-2098 (Reply 2009 vol 361 632).
Casasola,A. Ramos-Cerrillo,B. de Roodt,A.R. Saucedo,A.C. Chippaux,J.P. Alagon,A. Stock,R.P.
2009. Paraspecific neutralization of the venom of African species of cobra by an equine antiserum against Naja melanoleuca: A comparative study Toxicon, 53, 602-608.
Corzo,G. Bernard,C. Clement,H. Villegas,E. Bosmans,F. Tytgat,J. Possani,L.D. Darbon,H. Alagon,A.
2009. Insecticidal peptides from the theraposid spider Brachypelma albiceps: A NMR-based model of Ba2 Biochimica et Biophysica Acta (BBA), 1794, 1190-1196.
Chase,P. Boyer-Hassen,L. McNally,J. Vazquez,H.L. Theodorou,A.A. Walter,F.G. Alagon,A.
2009. Serum levels and urine detection of Centruroides sculpturatus venom in significantly envenomated patients Clinical Toxicology, 47, 24-28.
Ramos-Cerrillo,B. de Roodt,A.R. Chippaux,J.P. Olguin,L. Casasola,A. Guzman,G. Paniagua-Solis,J. Alagon,A. Stock,R.P.
2008. Characterization of a new polyvalent antivenom (Antivipmyn((R)) Africa) against African vipers and elapids Toxicon, 52, 881-888.
Chippaux,J.P. Alagon,A.
2008. [Envenomation and poisoning by venomous or poisonous animals. VII: arachnidism in the New World] Medecine Tropicale, 68, 215-221.
Corzo,G. Diego-Garcia,E. Clement,H. Peigneur,S. Odell,G. Tytgat,J. Possani,L.D. Alagon,A.
2008. An insecticidal peptide from the theraposid Brachypelma smithi spider venom reveals common molecular features among spider species from different genera Peptides, 29, 1901-1908.
de Roodt,A.R. Estevez-Ramirez,J. Litwin,S. Magana,P. Olvera,A. Alagon,A.
2007. Toxicity of two North American Loxosceles (brown recluse spiders) venoms and their neutralization by antivenoms Clinical Toxicology, 45, 678-687.
Chippaux,J.P. Massougbodji,A. Stock,R.P. Alagon,A.
2007. Clinical Trial of an F(ab')2 Polyvalent Equine Antivenom for African Snake Bites in Benin American Journal of Tropical Medicine and Hygiene, 77, 538-546.
Clement,H. Odell,G. Zamudio,F.Z. Redaelli,E. Wanke,E. Alagon,A. Possani,L.D.
2007. Isolation and characterization of a novel toxin from the venom of the spider Grammostola rosea that blocks sodium channels Toxicon, 50, 65-74.
D'Suze,G. Moncada,S. Gonzalez,C. Sevcik,C. Alagon,A.
2007. Antigenic cross-reactivity between sixteen venoms from scorpions belonging to six genera Clinical Toxicology, 45, 158-163.
Dragulev,B. Bao,Y. Ramos-Cerrillo,B. Vazquez,H. Olvera,A. Stock,R.P. Alagon,A. Fox,J.W.
2007. Upregulation of cytokine expression in fibroblasts exposed to Loxosceles sphingomyelinase D: What is the trigger? Journal of Investigative Dermatology, 127, 1267-1268.
Dragulev,B. Bao,Y. Ramos-Cerrillo,B. Vazquez,H. Olvera,A. Stock,R. Algaron,A. Fox,J.W.
2007. Upregulation of IL-6, IL-8, CXCL1, and CXCL2 Dominates Gene Expression in Human Fibroblast Cells Exposed to Loxosceles reclusa Sphingomyelinase D: Insights into Spider Venom Dermonecrosis Journal of Investigative Dermatology, 127, 1264-1266.
Olvera,A. Ramos-Cerrillo,B. Estevez,J. Clement,H. de Roodt,A. Paniagua-Solis,J. Vazquez,H. Zavaleta,A. Salas-Arruz,M. Stock,R.P. Alagon,A.
2006. North and South American Loxosceles spiders: Development of a polyvalent antivenom with recombinant sphingomyelinases D as antigens Toxicon, 48, 64-74.
Almagro,J.C. Martinez,L. Smith,S.L. Alagon,A. Estevez,J. Paniagua,J.
2006. Analysis of the horse V(H) repertoire and comparison with the human IGHV germline genes, and sheep, cattle and pig V(H) sequences Molecular Immunology, 43, 1836-1845.
Vazquez,H. Chavez-Haro,A. Garcia-Ubbelohde,W. Mancilla-Nava,R. Paniagua-Solis,J. Alagon,A. Sevcik,C.
2005. Pharmacokinetics of a F(ab')(2) scorpion antivenom in healthy human volunteers Toxicon, 46, 797-805.
Ramos,M.A. Sanchez-Lopez,R. Mares,R.E. Olvera,F. Alagon,A.
2005. Identification of an Entamoeba histolytica gene encoding a protein disulfide isomerase that functionally complements the dsbA mutation in Escherichia coli Molecular and Biochemical Parasitology, 143, 236-240.
Salgado,M. Villagomez-Castro,J.C. Rocha-Rodriguez,R. Sabanero-Lopez,M. Ramos,M.A. Alagon,A. Lopez-Romero,E. Sanchez-Lopez,R.
2005. Entamoeba histolytica: Biochemical and molecular insights into the activities within microsomal fractions Experimental Parasitology, 110, 363-373.
Sadurni,P. Alagon,A. Aliev,R. Burillo,G. Hoffman,A.S.
2005. Immobilization of streptavidin-horseradish peroxidase onto a biotinylated poly(acrylic acid) backbone that had been radiation-grafted to a PTFE film Journal of Biomaterials Science-Polymer Edition, 16, 181-187.
Sanchez,R. Saralegui,A. Olivos-Garcia,A. Scapolla,C. Damonte,G. Sanchez-Lopez,R. Alagon,A. Stock,R.P.
2005. Entamoeba histolytica: intracellular distribution of the sec61alpha subunit of the secretory pathway and down-regulation by antisense peptide nucleic acids Experimental Parasitology, 109, 241-251.
Ramos-Cerrillo,B. Olvera,A. Odell,G.V. Zamudio,F. Paniagua-Solis,J. Alagon,A. Stock,R.P.
2004. Genetic and enzymatic characterization of sphingomyelinase D isoforms from the North American fiddleback spiders Loxosceles boneti and Loxosceles reclusa Toxicon, 44, 507-514 [Correction TOXICON 46 (2): 241-241 AUG 2005].
de Roodt,A.R. Paniagua-Solis,J.F. Dolab,J.A. Estevez-Ramirez,J. Ramos-Cerrillo,B. Litwin,S. Dokmetjian,J.C. Alagon,A.
2004. Effectiveness of two common antivenoms for North, Central, and South American Micrurus envenomations Journal of Toxicology, 42, 171-178.
D'Suze,G. Moncada,S. Gonzalez,C. Sevcik,C. Aguilar,V. Alagon,A.
2003. Relationship between plasmatic levels of various cytokines, tumour necrosis factor, enzymes, glucose and venom concentration following Tityus scorpion sting Toxicon, 41, 367-375.
Sanchez,R. Alagon,A. Stock,R.P.
2002. Entamoeba histolytica: intracellular distribution of the proteasome Experimental Parasitology, 102, 187-190.
Nieto-Sotelo,J. Martinez,L.M. Ponce,G. Cassab,G.I. Alagon,A. Meeley,R.B. Ribaut,J.M. Yang,R.
2002. Maize HSP101 Plays Important Roles in Both Induced and Basal Thermotolerance and Primary Root Growth Plant Cell, 14, 1621-1633.
Ramos,M.A. Sanchez-Lopez,R. Olvera,F. Alagon,A.
2002. Entamoeba histolytica genomic organization: identification, structure, and phylogenetic relationship of two serine-threonine protein kinases Experimental Parasitology, 100, 135-139.
Juarez,P. Sanchez-Lopez,R. Stock,R.P. Olvera,A. Ramos,M.A. Alagon,A.
2001. Characterization of the Ehrab8 gene, a marker of the late stages of the secretory pathway of Entamoeba histolytica Molecular and Biochemical Parasitology, 116, 223-228.
Stock,R.P. Olvera,A. Sanchez,R. Saralegui,A. Scarfi,S. Sanchez-Lopez,R. Ramos,M.A. Boffa,L.C. Benatti,U. Alagon,A.
2001. Inhibition of gene expression in Entamoeba histolytica with antisense peptide nucleic acid oligomers Nature Biotechnology, 19, 231-234.
Sanchez-Lopez,R. Gutierrez,A. Juarez,P. Olvera,A. Olvera,F. Ramos,M.A. Sanchez,R. Saralegui,A. Stock,R.P. Alagon,A.
2000. Molecular genetics of the secretory pathway in Entamoeba histolytica: an overview Archives of Medical Research, 31, S151-S152.
Juarez,P. Sanchez-Lopez,R. Ramos,M.A. Stock,R.P. Alagon,A.
2000. Rab8 as a molecular model of vesicular trafficking to investigate the latter steps of the secretory pathway in Entamoeba histolytica Archives of Medical Research, 31, S157-S159.
Gutierrez,A. Sanchez-Lopez,R. Ramos,M.A. Alagon,A.
2000. Cloning of the Entamoeba histolytica STT3 gene, a subunit of the oligosaccharyltransferase complex Archives of Medical Research, 31, S162-S164.
Sanchez-Lopez,R. Siminovich,B. Alagon,A.
2000. Entamoeba histolytica codes for a protein homologue of the Sec61 alpha subunit, a component of the endoplasmic reticulum translocon Archives of Medical Research, 31, S168-S170.
Ramos,M.A. Alagon,A.
2000. Molecular cloning of a gene encoding a PDI-like protein from Entamoeba histolytica Archives of Medical Research, 31, S173-S175.
Ramos,M.A. Sanchez-Lopez,R. Alagon,A.
2000. Genomic organization of a 7 Kb gene cluster from Entamoeba histolytica Archives of Medical Research, 31, S263-S265.
Stock,R.P. Olvera,A. Scarfi,S. Sanchez,R. Ramos,M.A. Boffa,L.C. Benatti,U. Landt,O. Alagon,A.
2000. Inhibition of neomycin phosphorotransferase expression in Entamoeba histolytica with antisense peptide nucleic acid (PNA) oligomers Archives of Medical Research, 31, S271-S272.
Que,X. Kim,D. Alagon,A. Hirata,K. Shike,H. Shimizu,C. Gonzalez,A. Burns,J.C. Reed,S.L.
1999. Pantropic retroviral vectors mediate gene transfer and expression in Entamoeba histolytica Molecular and Biochemical Parasitology, 99, 237-245.
Sanchez-Gonzalez,M. Alagon,A. Rodriguez-Sotres,R. Lopez-Munguia,A.
1999. Proteolytic processing of dextransucrase of Leuconostoc mesenteroides Fems Microbiology Letters, 181, 25-30.
Sanchez-Lopez,R. Gama-Castro,S. Ramos,M.A. Merino,E. Lizardi,P.M. Alagon,A.
1998. Cloning and expression of the Entamoeba histolytica ERD2 gene Molecular and Biochemical Parasitology, 92, 355-359.
(error para zzvargas) Olvera-Rodriguez,A. Mata-Cardenas,B.D. Martinez-Rodriguez,H.G. Said-Fernandez,S. Alagon-Cano,A.
1998. Isolation of an Entamoeba histolytica intracellular alkaline phospholipase A(2) Parasitology Research, 84, 310-314.
Ramos,M.A. Stock,R.P. Lizardi,P.M. Alagon,A.
1997. The secretory pathway of Entamoeba histolytica: characterization and expression of the SRP54 gene.Archives of Medical Research, 28, 56-58.
Sanchez-Lopez,R. Gama-Castro,S. Lizardi,P.M. Alagon,A.
1997. The secretory pathway of Entamoeba histolytica: characterization and expression of the ERD2 gene.Archives of Medical Research, 28, 59-61.
Ramos,M.A. Stock,R.P. Sanchez-Lopez,R. Olvera,F. Lizardi,P.M. Alagon,A.
1997. The Entamoeba histolytica proteasome alpha-subunit gene Molecular and Biochemical Parasitology, 84, 131-135.
Olvera,A. Olvera,F. Vines,R.R. Recillas-Targa,F. Lizardi,P.M. Dhar,S. Bhattacharya,S. Petri,W.J. Alagon,A.
1997.
Stable transfection of Entamoeba histolytica trophozoites by lipofection Archives of Medical Research, 28 ., 49-51.
Ramos,M.A. Mercado,G.C. Salgado,L.M. Sanchez-Lopez,R. Stock,R.P. Lizardi,P.M. Alagon,A.
1997. Entamoeba histolytica contains a gene encoding a homologue to the 54 kDa subunit of the signal recognition particle Molecular and Biochemical Parasitology, 88, 225-235.
Estrada,G. Colin,L. Gaytan,P. Alagon,A. Lizardi,P.M.
1996. Sequence-specific detection of PCR-amplified DNA by restriction enzyme release of hybrids Mol.Cell Probes, 10, 179-185.
Miranda,R. Salgado,L.M. Sanchez-Lopez,R. Alagon,A. Lizardi,P.M.
1996. Identification and analysis of the u6 small nuclear RNA gene from Entamoeba histolytica Gene, 180, 37-42.
Michel,B. Lizardi,P.M. Alagon,A. Zurita,M.
1995. Identification and analysis of the start site of ribosomal RNA transcription of Entamoeba histolytica Molecular and Biochemical Parasitology, 73, 19-30.
Noeske-Jungblut,C. Haendler,B. Donner,P. Alagon,A. Possani,L. Schleuning,W.D.
1995. Triabin, a highly potent exosite inhibitor of thrombin Journal of Biological Chemistry, 270, 28629-28634.
Noeske-Jungblut,C. Kratzschmar,J. Haendler,B. Alagon,A. Possani,L. Verhallen,P. Donner,P. Schleuning,W.D.
1994. An inhibitor of collagen-induced platelet aggregation from the saliva of Triatoma pallidipennis Journal of Biological Chemistry, 269, 5050-5053.
Palmeros,B. Guereca,L. Alagon,A. Soberon-Chavez,G.
1994. Biochemical characterization of the lipolytic activity of pseudomonas aeruginosa IGB 83 Process Biochemistry, 29, 207-212.
Cevallos,M.A. Porta,H. Alagon,A.C. Lizardi,P.M.
1993. Sequence of the 5.8S ribosomal gene of pathogenic and non-pathogenic isolates of Entamoeba histolytica Nucleic Acids Research, 21, 355-355.
Possani,L.D. Fletcher,P.L. Fletcher,M.D. Rode,G.S. Mochca-Morales,J. Lucas,S. Coronas,F.V. Alagon,A.C. Martin,B.M.
1992. Structural and functional characteristics of toxins purified from the venom of the Brazilian scorpion Tityus serrulatus Lutz and Mello.Memorias do Instituto Butantan, 54, 35-52.
Michel,B. Alagon,A. Lizardi,P.M. Zurita,M.
1992. Characterization of a repetitive DNA element from Entamoeba histolytica Molecular and Biochemical Parasitology, 51, 165-168.
Cevallos,M.A. Navarro-Duque,C. Varela-Julia,M. Alagon,A.C.
1992. Molecular mass determination and assay of venom hyaluronidases by sodium dodecyl sulfate-polyacrylamide gel electrophoresis Toxicon, 30, 925-930.
Schleuning,W.D. Alagon,A. Boidol,W. Bringmann,P. Petri,T. Kratzschmar,J. Haendler,B. Langer,G. Baldus,B. Witt,W.
1992. Plasminogen activators from the saliva of Desmodus rotundus (common vampire bat): unique fibrin specificity Annals of the New York Academy of Sciences, 667, 395-403 * .
(error para zzvargas) Martin-Polo,J.J. Reynaud,E. Alagon,A.C.
1991. A new affinity adsorbent for the purification of phospholipases A1 and A2 from animal venoms Toxicon, 29, 119-124.
Zurita,M. Alagon,A. (error para zzvargas) Lizardi,P.M.
1991. The Entamoeba histolytica rDNA episome: nuclear localization, DNAase I sensitivity map, and specific DNA-protein interactions Molecular Microbiology, 5, 1843-1851.
Kratzschmar,J. Haendler,B. Langer,G. Boidol,W. Bringmann,P. Alagon,A. Donner,P. Schleuning,W.D.
1991. The plasminogen activator family from the salivary gland of the vampire bat Desmodus rotundus: cloning and expression Gene, 105, 229-237.
Laclette,J.P. Alagon,A. Willms,K. Torre-Blanco,A.
1990. Purification of antigen B from Taenia solium cysticerci by affinity to mammalian collagen Journal of Parasitology, 76, 273-275.
Alagon,A.C. Guzman,H.S. Martin,B.M. Ramirez,A.N. Carbone,E. Possani,L.D.
1988. Isolation and characterization of two toxins from the Mexican scorpion Centruroides limpidus limpidus Karsch Comp.Biochem.Physiol.B Biochem.Mol.Biol., 89, 153-161.
Sosa,B.P. Alagon,A.C. Martin,B.M. Possani,L.D.
1986. Biochemical characterization of the phospholipase A2 purified from the venom of the Mexican beaded lizard (Heloderma horridum horridum Wiegmann) Biochemistry, 25, 2927-2933 * .
Alagon,A. Possani,L.D. Smart,J. Schleuning,W.D.
1986. Helodermatine, a kallikrein-like, hypotensive enzyme from the venom of Heloderma horridum horridum (Mexican beaded lizard) Journal of Experimental Medicine, 164, 1835-1845.
King,T.P. Alagon,A.C. Kuan,J. Sobotka,A.K. Lichtenstein,L.M.
1983. Immunochemical studies of yellowjacket venom proteins Molecular Immunology, 20, 297-308 * .
Alagon,A.C. Maldonado,M.E. Julia,J.Z. Sanchez,C.R. Possani,L.D.
1982. Venom from two sub-species of Heloderma horridum (Mexican beaded lizard): general characterization and purification of N-benzoyl-L-arginine ethyl ester hydrolase Toxicon, 20, 463-475 * .
Possani,L. Steinmetz,W.E. Dent,M.A. Alagon,A.C. Wuthrich,K.
1981. Preliminary spectroscopic characterization of six toxins from Latin American scorpions Biochimica et Biophysica Acta (BBA), 669, 183-192 * .
King,T.P. Alagon,A. Kochoumian,L. Kuan,J. Sobotka,A. Lichtenstein,L.M.
1981. Limited proteolysis of antigens E and K from ragweed pollen Archives of Biochemistry and Biophysics, 212, 127-135 * .
Possani,L.D. Sosa,B.P. Alagon,A.C. Burchfield,P.M.
1980. The venom from the snakes Agkistrodon bilineatus Taylori and Crotalus durissus Totonacus: lethality, biochemical and immunological properties Toxicon, 18, 356-360 * .
Possani,L.D. Fletcher,P.L. Alagon,A.B. Alagon,A.C. Julia,J.Z.
1980. Purification and characterization of a mammalian toxin from venom of the Mexican scorpion, Centruroides limpidus tecomanus Hoffmann Toxicon, 18, 175-183 * .
Alagon,A.C. Molinar,R.R. Possani,L.D. Fletcher,P.L. Cronan,J.E. Julia,J.Z.
1980. Venom from the snake Bothrops asper Garman. Purification and characterization of three phospholipases A2 Biochemical Journal, 185, 695-704 * .
Alagon,A.C. King,T.P.
1980. Activation of polysaccharides with 2-iminothiolane and its uses Biochemistry, 19, 4341-4345 * .
Sosa,B.P. Alagon,A.C. Possani,L.D. Julia,J.Z.
1979. Comparison of phospholipase activity with direct and indirect lytic effects of animal venoms upon human red cells Comparative Biochemistry and Physiology Part B: Comparative Biochemistry, 64, 231-234 * .
Possani,L.D. Alagon,A.C. Fletcher,P.L. Varela,M.J. Julia,J.Z.
1979. Purification and characterization of a phospholipase A2 from the venom of the coral snake, Micrurus fulvius microgalbineus (Brown and Smith) Biochemical Journal, 179, 603-606 * .
King,T.P. Sobotka,A.K. Alagon,A. Kochoumian,L. Lichtenstein,L.M.
1978. Protein allergens of white-faced hornet, yellow hornet, and yellow jacket venoms Biochemistry, 17, 5165-5174 * .
Possani,L.D. Alagon,A.C. Fletcher,P.L. Erickson,B.W.
1977. Purification and properties of mammalian toxins from the venom of Brazilian Scorpion Tityus serrulatus Lutz and Mello Archives of Biochemistry and Biophysics, 180, 394-403 * .
Frenk,J. Acuna,D.L. Bobadilla,J.L. Alagon,A.
1976. [Liberal medicine and institutional medicine in Mexico].Salud Publica de Mexico, 18, 481-493 * .
Libros y capítulos recientes Paniagua,D. Vergara,I. Boyer,L. Alagon,A. 2017. Role of Lymphatic System on Snake Venom Absorption en: Rahmy,T.R. Snake Venoms. Toxicology Series.. Dordrecht. Springer Netherlands. pags. 453-474
Paniagua,D. Vergara,I. Boyer,L. Alagon,A. 2015. Role of Lymphatic System on Snake Venom Absorption en: Vogel,C.W. Snake Venoms. Springer Netherlands. pags. 1-19
Boyer,L. Alagon,A. Fry,B.G. Jackson,T.N.W. Sunagar,K. Chippaux,J.P. 2015. Signs, symptoms and treatment of envenomation en: Fry,B. Venomous Reptiles and Their Toxins: Evolution, Pathophysiology and Biodiscovery. New York. Oxford University Press. pags. 32-60
Benard-Valle,M. Neri,E. Fry,B. Boyer,L. Sheira,D. Olvera,F. Alagon,A. 2015. Antivenom research and development en: Fry,B. Venomous reptiles and their toxins: Evolution, pathophysiology and biodiscovery. New York. Oxford University Press. pags. 61-72
Alagon,A. Odell,G. 2011. La biologia y taxonomia de las aranas americanas en: Paniagua Solis,J.F. Emergencias por Animales Ponzonosos en las Americas. Mexico. Instituto Bioclon. pags. 181-201
Alagon,A. Possani,L.D. 2003. Desarrollo de nuevos fármacos a partir de la fauna tropical en: Lopez-Munguia,A. Fronteras de la Biología en los Inicios del Siglo XXI, Módulo VII.. Mexico,D.F.. El Colegio Nacional. pags. 123-160
Alagon,A. Carillo,C. Chavez-Haro,A. De la Mora-Zerpa,C. Larralde,C. Lamas,N. Martin,E. Osnaya-Romero,N. Perez,Y. Possani,L.D. Romero-Zamora,L. 2003. Práctica Médica Efectiva- Alacranismo (T63.2, X22) Mexico:. Instituto Nacional de Salud Pública.
Gosset,G. Bolivar,F. Soberon,X. Lopez-Munguia,A. Valderrama,B. Ayala,M. Vazquez,R. Ramirez,O.T. Alagon,A. Possani,L.D. 2003. Fronteras de la Biología en los Inicios del Siglo XXI. Módulo VII: Ingeniería Celular, Biodiversidad e Industria. Mexico, D.F.: El Colegio Nacional.
Estrada,G. Sanchez,R. Lizardi,P.M. Alagon,A. 1998. 4 en: Biologia molecular en medicina. Mexico DF. Editorial Grupo Noriega. pags. 47-60
DehesaDavila,M. Alagon,A.C. Possani,L.D. 1995. Clinical toxicology of scorpion stings en: White,J. Handbook of clinical toxicology of animal venoms and poisons. New York. CRC Press. pags. 221-238
Divulgación Corzo-Burguete,G. Alagon-Cano,A. Clement-Carretero,H. Jurado-Reyes,S.M. Herrera-Herrera,E.
2014. Los venenos de tarántulas y la absorción de medicinas en nuestro cuerpo Hypatia, 48, .
Neri-Castro,E. Benard-Valle,M. Alagon-Cano,A.
2014. Reptiles venenosos en México Revista Digital Universitaria, 15, art 86.
Sanchez-Villegas,M.d.C. Rodriguez-Alvarez,D. Ortega-Carrillo,C. Alagon-Cano,A. Zaldívar-Cervera,J. Loría-Castellanos,J. Urzúa-Rodríguez,N.A.
2014. [Systemic loxoscelism presented in a pregnant patient]. Revista Médica del Instituto Mexicano del Seguro Social, 52, 98-103.
Neri-Castro,E. Alagon-Cano,A.
2013. Venenos que matan: Serpientes Hypatia, 46, .
Alagon-Cano,A. Corzo,G. Clement-Carretero,H. Garcia-Garcia,F.
2010. Arañas: venenos con potencial biotecnológico. Hypatia, 33, .
Rodriguez,M. Prud`Homme,M. Alagon,A. Stock,R.
2009. Expresión de a-latrotoxina Recombinante Activa de Latrodectus mactans Utilizando el Sistema de Células de Insecto-Baculovirus Biotecnologia, 13, 34-47.
Mata-Gonzalez,M.T. Garcia-Ubbelohde,W. Alagon-Cano,A. Paniagua-Solis,J.
2008. Anticuerpos monoclonales para uso terapéutico en humanos.Informaceutico Mexico, 15, 30-36.
Rendon-Anaya,M. Alagon,A.
2008. Mecanismos moleculares de diversificación de inmunoglobulinas Revista de Educación Bioquímica, 27, 19-29.
Olvera-Rodriguez,A. Alagon-Cano,A. Ramos-Cerrillo,B. Cardoso-Torres,H.M. Olvera-Rodriguez,F.
2007. La partitura de la araña violinista: Envenenamiento fatal Hypatia, 22, .
Alagon,A. Clement-Carretero,H. Lomonte,B. Gutierrez,J.M. Ownby,C.L.
2007. Obituary of George V. Odell, 1926-2006 Toxicon, 49, 886-887.
Stock,R.P. Massougbodji,A. Alagon,A. Chippaux,J.P.
2007. Bringing antivenoms to Sub-Saharan Africa Nature Biotechnology, 25, 173-177.
de Roodt,A.R. Salomon,O.D. Orduna,T.A. Robles-Ortiz,L.E. Paniagua-Solis,J.F. Cano,A.A.
2005. Poisoning by bee sting Gaceta Medica de Mexico, 141, 215-222.
Chippaux,J.P. Stock,R.P. Alagon,A.
2005. Report of the 2nd international conference on envenomations in Africa (Deuxieme colloque international sur les envenomations en Afrique) Toxicon, 46, 115-118.
de Roodt,A.R. Estevez-Ramirez,J. Paniagua-Solis,J.F. Litwin,S. Carvajal-Saucedo,A. Dolab,J.A. Robles-Ortiz,L.E. Alagon,A.
2005. [Toxicity of venoms from snakes of medical importance in Mexico] Gaceta Medica de Mexico, 141, 13-21.
Alagon,A. Odell,G.
2004. Neutralization of Centruroides noxius envenomization of a gila monster.Forum Magazine.American Tarantula Society, 13, 75.
Alagon,A. Odell,G.
2004. Acroceroide parasitism of the Mexican tarantula Aphonopelma duplex.Forum Magazine.American Tarantula Society, 13, 57-58.
Obregon,A. Saab,J. Rodriguez,R. Alagon,A. Farres,A.
2002. Logros y retos del Posgrado en Ciencias Bioquimicas de la UNAM.Revista de Educación Bioquímica, 21, 133-139.
Alagon,A.
2002. Anticuerpos seguros y eficaces: la revoluacion de los nuevos antivenenos Revista Universidad de Mexico, 617, .
Alagon,A.
2001. Ruta secretoria y Entamoeba histolytica.Mensaje Bioquimico, 25, .
Estrada,B. Scheinvar,L. Alagon,A. Olalde,G.
2000. Resultados preliminares de electroforesis en proteínas como método auxiliar en la taxonomía de Opuntia spp.Acta Cientifica Potosina, 15, 7-24.
Alagon,A. Cortes,A. Olvera,F. Olvera,A. Gonzalez,A. Lizardi,P.M.
1996. Diseño y construcción de vectores para la transformación estable de Entamoeba histolytica.Gaceta médica de México, 132, 476-482.
Ortega-Pierres,G. Alagon,A. Cortes,A. Olvera,F. Olvera,A. Gonzalez,A. Lizardi,P. Berzunza-Cruz,M. Saavedra-Lira,E. Perez-Montfort,R. Velasco-Castrejon,O. Sotero-Delgado Dominguez,I. Becker,I. Hernandez,R. Martinez-Calvillo,S. Frixione,E. Ruiz,L. Santillan,M. Vega,L. Tejero,J.M. Undeen,A.H. Kretschmer,R.R. Herion,P. Saavedra,R. Yepez-Mulia,L.
1996. [Impact of new methodologies in the study of parasites].Gaceta Medica de Mexico, 132, 475-517.
Arauco,R. Alagon,A.
1979. [Propanolol in arterial hypertension. Beta-blockaders. Recent advances].Prensa médica mexicana, 44, 97-104 * .
Patentes De la Rosa, G., García-Corrales, L.L., Alagón, A., Corzo, G., 2016 Inmunógenos recombinantes para la producción de antivenenos contra el veneno de elápidos del género Micrurus.UNAM México. (en trámite)
A. Alagón C., L. D. Possani P, G. Gurrola B., E. V. Grishin, A. V. Lipkin & K. E. Volynski 2010 Inmunógeno, anti-veneno y vacuna contra el veneno de la araña viuda negra.UNAM Mexico.
A. Olvera, R. P. Stock, B. M. Ramos, R. Sánchez y A. Alagón 2007 Inmunógeno y anti-veneno contra el veneno de la araña violinista.UNAM-Silanes Ecuador sp-07-7362, Australia 2005280742, Brasil PI0514809-0, Estados Unidos 11/574,488, Colombia 03082717, Costa Rica sin número y México MX/2007/002425. (en trámite)
A. Olvera, R. P. Stock, B. M. Ramos, R. Sánchez y A. Alagón 2007 Inmunógeno y anti-veneno contra el veneno de la araÒa violinista.UNAM-Silanes Ecuador, Australia, Brasil , Estados Unidos, Colombia y México. (en trámite)
A. Olvera, R. P. Stock, B. M. Ramos y A. Alagón 2005 Inmunógeno y anti-veneno contra el veneno de la araña violinista.Copropiedad de la UNAM-Silanes Perú.
A. Olvera, R. P. Stock, B. M. Ramos, R. Sánchez y A. Alagón 2005 Inmunógeno y anti-veneno contra el veneno de la araña violinista.UNAM-Silanes PCT, Nacionales en Chile 2223-05, Argentina P050103622 y Venezuela 2005-001775. (en trámite)
A. Olvera, R. P. Stock, B. M. Ramos y A. Alagón 2004 Inmunógeno y anti-veneno contra el veneno de la araña violinista.Copropiedad de la UNAM-Silanes México. (en trámite)
G. Gurrola, A. Alagón C. L. D. Possani P., E. V. Grishin, A. V. Lipkin y K. E. Volynski 2002 Immunogen, Anti-Venom and Vaccine Against the Venom of the Black Widow Spider.UNAM Estados Unidos, Europa EP00980069.9 y Canadá 2,397,731.
G. Gurrola B., A. Alagón C., L. D. Possani P., E. V. Grishin, A. V. Lipkin y K. E. Volynski 2000 Inmunógeno, anti-veneno y vacuna contra el veneno de la araña viuda negra.UNAM PCT.
B.Baldus, P.Donner, W.D Schleuning, A. Alagon, W.Boidol, J. R. Kratzschmar, B. J. Haendler y G.Langer 1999 Plasminogen activator from saliva of vampire bat.Schering Estados Unidos.
C. Noeske-Jungblut, W.D. Schleuning, A. Alagon, L.D Possani, D.A. Cuevas-Aguirre, P. Donner, B. Haendler y U. Hechler 1999 Thormbin inhibitor from saliva protostomia.Schering Estados Unidos.
A. Alagón C., L. D. Possani P., G. Gurrola B., E. V. Grishin, A. V. Lipkin y K. E. Volynski 1999 Inmunógeno, anti-veneno y vacuna contra el veneno de la araña viuda negra.UNAM-Inst. de QuÍmica Bioorgánica México. (en trámite)
C. Noeske-jungbut, B. Haendler, J.R. kraestzschmar, W.D. Schlenuning, A. Alagon, L.D. possani, yD.A Cuevas-Aguirre 1998 Collagen-induced platelet aggration inhibitor.Schering Estados Unidos.
C. Noeske-jungbut, B. Haendler, J.R. kraestzschmar, W.D. Schlenuning, A. Alagon, L.D. possani, y D.A Cuevas-Aguirre 1998 Collagen-induced platelet aggration inhibitor.Schering Europa.
C. Noeske-jungbut B. Haendler J.R. kraestzschmar W.D. Schlenuning A. Alagon L.D. possani D.A Cuevas-Aguirre 1998 Collagen-induced platelet aggration inhibitor.Schering Europa.
C. Noeske-jungblut W.D. Schelunig A. Alagon L.D. Possani D.A. Cuevas-Aguirre P. Donner B. Haendler y U. Hechler 1997 Clotting inhibitor made from protostomia saliva.Schering Europa.
B. Baldus P. Donner W.D. Schleuning A. Alagon W. boidol J.R. Kratzschmar B.J Haendler y G. Lager 1995 Vampire bat salivary plasminogen activator vPA-alpha 1.
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