Instituto de Biotecnologia UNAM

IBT-UNAM : Dra. Patricia Ileana Joseph Bravo

Dra. Patricia Ileana Joseph Bravo


Líder Académico »» Grupo

Investigador

Tutor de Maestría y Doctorado

Nivel III del SNI

Departamento de Genética del Desarrollo y Fisiología Molecular

Líneas de investigación

email: joseph@ibt.unam.mx

Teléfonos

Fax +52 (777) 3170805

Laboratorio +52 (777) 329-1620
desde el D.F. 562-27620

red UNAM 27620


- Licenciatura: Química, Fac. de Química-UNAM (1970)
- Maestría: en Nutricion y Metabolismo. Mass. Inst. of Technology, Cambridge, Mass E.U.A. Dept. de Ciencia en Nutrición y Metabolismo (1974)
- Doctorado: en Bioquímica, Universidad de Londres, Colegio Imperial de Ciencia y Tecnología , Depto. de Bioquímica, Londres, Inglaterra (1978)


Miembro del Consejo Consultivo de Posgrado de la UNAM (2003)
Distinción Juana Ramírez de Abaje UNAM (2003)
Premio Miguel Aleman (1988)


Estudiantes

Biol. Blas Roberto Osores

M.C. Adrian Perez

M.C. Israim Sotelo

Publicaciones recientes

Sotelo-Rivera,I. Jaimes-Hoy,L. Cote-Velez,A. Espinoza-Ayala,C. Charli,J.L. Joseph-Bravo,P. 2014. An acute injection of corticosterone increases thyrotrophin releasing hormone expression in the paraventricular nucleus of the hypothalamus but interferes with the rapid hypothalamus pituitary thyroid axis response to cold in male rats Journal of Neuroendocrinology, 26, 861-869.

Rodriguez-Molina,V. Patino,J. Vargas,Y. Sanchez-Jaramillo,E. Joseph-Bravo,P. Charli,J.L. 2014. TRH regulates action potential shape in cerebral cortex pyramidal neurons Brain Research, 1571, 1-11.

Uribe,R.M. Jaimes-Hoy,L. Ramirez-Martinez,C. Garcia-Vazquez,A. Romero,F. Cisneros,M. Cote-Velez,A. Charli,J.L. Joseph-Bravo,P. 2014. Voluntary exercise adapts the hypothalamus-pituitary-thyroid axis in male rats Endocrinology, 155, en20131724.

Gutierrez-Mariscal,M. Sanchez,E. Garcia-Vazquez,A. Rebolledo-Solleiro,D. Charli,J.L. Joseph-Bravo,P. 2012. Acute response of hypophysiotropic thyrotropin releasing hormone neurons and thyrotropin Regulatory Peptides, 179, 61-70.

Lazcano,I. Uribe,R.M. Martinez-Chavez,E. Vargas,M.A. Matziari,M. Joseph-Bravo,P. Charli,J.L. 2012. Pyroglutamyl peptidase II inhibition enhances the analeptic effect of thyrotropin releasing hormone in the rat medial septum Journal of Pharmacology and Experimental Therapeutics, 342, 222-231.

Gutierrez-Mariscal,M. Sanchez,E. Rebolledo-Solleiro,D. Garcia-Vazquez,A.I. Cote-Velez,A. Acasuso-Rivero,C. Charli,J.L. Joseph-Bravo,P. 2012. The acute response of the amygdalar TRH system to psychogenic stressors varies dependent on the paradigm and circadian condition Brain Research, 1452, 73-84.

Guerra-Crespo,M. Perez-Monter,C. Janga,S.C. Castillo-Ramirez,S. Gutierrez-Rios,R.M. Joseph-Bravo,P. Perez-Martinez,L. Charli,J.L. 2011. Transcriptional profiling of fetal hypothalamic TRH neurons BMC Genomics, 12, 222.

Cote-Velez,A. Perez-Maldonado,A. Osuna,J. Barrera,B. Charli,J.L. Joseph-Bravo,P. 2011. Creb and Sp/Kruppel response elements cooperate to control rat TRH gene transcription in response to cAMP Biochimica et Biophysica Acta (BBA), 1809, 191-199.

Uribe,R.M. Cisneros,M. Vargas,M.A. Lezama,L. Cote-Velez,A. Joseph-Bravo,P. Charli,J.L. 2011. The systemic inhibition of nitric oxide production rapidly regulates TRH mRNA concentration in the paraventricular nucleus of the hypothalamus and serum TSH concentration. Studies in control and cold-stressed rats Brain Research, 1367, 188-197.

Diaz-Gallardo,M.Y. Cote-Velez,A. Charli,J.L. Joseph-Bravo,P. 2010. A rapid interference between glucocorticoids and cAMP-activated signaling in hypothalamic neurons prevents binding of pCREB and GR at the CRE-like and composite GRE sites of TRH gene promoter Journal of Neuroendocrinology, 22, 282-293.

Diaz-Gallardo,M.Y. Cote-Velez,A. Carreon-Rodriguez,A. Charli,J.L. Joseph-Bravo,P. 2010. Phosphorylated Cyclic-AMP-Response Element-Binding Protein and Thyroid Hormone Receptor Have Independent Response Elements in the Rat Thyrotropin-Releasing Hormone Promoter: An Analysis in Hypothalamic Cells Neuroendocrinology, 91, 64-76.

Libros y capítulos recientes

de Gortari,P. Joseph-Bravo,P. 2010. Regulacion neuroendocrina del apetito en: Obesidad. Un enfoque multidisciplinario. Pachuca. Universidad Autonoma del Edo. de Hidalgo. pags. 57-71



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