 | Dr. Lourival Domingos Possani Postay Departamento de Medicina Molecular y Bioprocesos
Teléfonos (52+55) 562-27647Local (52+777) 329-1647 red UNAM 27647 oficina (52+777) 311-4900 x 280 fax (52+55) 562-27657 Local (52+777) 329-1657 red UNAM 27657 |
- Licenciatura: Historia Natural, Fac. de Filosofía de la Universidad Federal de Río Grande do Sul, Brasil (1966)
- Doctorado: en Biofísica, Faculte des Sciences D'Orsay-Universite de París, Francia (octubre 1968-marzo 1970)
- Mencion honorífica en examen de Doctorado (1970)
- Estancia de investigacion en la Universidad Rockefeller, New York, E.U.A. (julio 1971-septiembre 1973)
Premio Redi International Society on Toxinology (2006)
Investigador emérito UNAM (2005)
Doctor Honoris Causa Universidad de Debrecen, Hungría (2005)
Miembro de la Academia de Ciencias de America Latina (1999)
Premio Nacional de Investigación Básica Fundación Glaxo-Wellcome (1998)
Howard Hughes Medical Institute International Research Scholar 1997-2001 (1997)
Premio Nacional de Ciencias y Artes Gobierno de la República (1995)
Premio de Investigacion Medica Dr. Jorge Rosenkran (1994)
Premio Universidad Nacional en el área de Ciencias Naturales UNAM (1993)
Howard Hughes Medical Institute International Research Scholar 1991-1996 (1991)
M.C. Juan Canul "¿Cómo reconoce un anticuerpo neutralizante a una toxina de alacrán? el caso de la interfaz entre el BCF2 y la CN2?" Martha Rosalia Rendon Edgar Omar Pina M.C. Juana Jimenez "Toxinas de alacrán que afectan a canales de potasio del tipo HERG" M.C. Itzel Amaro "Construcción y caracterización de una biblioteca de fragmentos variables de anticuerpos de cadena pesada de Lama glama desplegados en fagos"
Redaelli,E. Restano-Cassulini,R. Fuentes-Silva D. Clement,H. Schiavon,E. Zamudio,F.Z. Odell,G. Arcangeli,A. Clare,J.J. Alagon,A. Rodriguez de la Vega RC Possani,L.D. Wanke,E.
2010.
Target promiscuity and heterogeneous effects of tarantula venom peptides affecting Na+ and K+ ion channels J Biol Chem, 285, 4130-4142.
de Roodt,A.R. Coronas,F.I. Lago,N. Gonzalez,M.E. Laskowicz,R.D. Beltramino,J.C. Saavedra,S. Lopez,R.A. Reati,G. Vucharchuk,M.G. Bazan,E. Varni,L. Salomon,O.D. Possani,L.D.
2010.
General, biochemical and immunological characterization of the venom from the scorpion tityus trivittatus of argentina Toxicon, 55, 307-319.
Zhu,S. Gao,B. Aumelas,A. Rodriguez,M.D. Lanz-Mendoza,H. Peigneur,S. Diego-Garcia,E. Martin-Eauclaire,M.F. Tytgat,J. Possani,L.D.
2009.
MeuTXKbeta1, a scorpion venom-derived two-domain potassium channel toxin-like peptide with cytolytic activity Biochimica et Biophysica Acta (BBA) Proteins & Proteomics, Dec 30. [Epub ahead of print], .
Rodriguez,A. Villegas,E. Satake,H. Possani,L.D. Corzo,G.
2009.
Amino acid substitutions in an alpha-helical antimicrobial arachnid peptide affect its chemical properties and biological activity towards pathogenic bacteria but improves its therapeutic index Amino Acids, Dec 24. [Epub ahead of print], .
Rodriguez de la Vega RC Schwartz,E.F. Possani,L.D.
2009.
Mining on scorpion venom biodiversity Toxicon, Nov 17. [Epub ahead of print], .
Espino-Solis,G.P. Calderon-Amador,J. Calderon-Aranda,E.S. Licea,A.F. Donis-Maturano,L. Flores-Romo,L. Possani,L.D.
2009.
Rational design of synthetic peptides to generate antibodies that recognize in situ CD11c+ putative dendritic cells in horse lymph nodes Veterinary Immunology and Immunopathology, 132, 181-190.
Corzo,G. Prochnicka-Chalufour,A. Garcia,B.I. Possani,L.D. Delepierre,M.
2009.
Solution structure of Cn5, a crustacean toxin found in the venom of the scorpions Centruroides noxius and Centruroides suffusus suffusus Biochim Biophys Acta, 1794, 1591-1598.
Hernandez-Salgado,K. Estrada,G. Olvera,A. Coronas,F.I. Possani,L.D. Corzo,G.
2009.
Heterologous expressed toxic and non-toxic peptide variants of toxin CssII are capable to produce neutralizing antibodies against the venom of the scorpion Centruroides suffusus suffusus Immunol Lett, 125, 93-99.
Papp,F. Batista,C.V. Varga,Z. Herceg,M. Roman-Gonzalez,S.A. Gaspar,R. Possani,L.D. Panyi,G.
2009.
Tst26, a novel peptide blocker of Kv1.2 and Kv1.3 channels from the venom of Tityus stigmurus Toxicon, 54, 379-389.
D'Suze,G. Schwartz,E.F. Garcia,B.I. Sevcik,C. Possani,L.D.
2009.
Molecular cloning and nucleotide sequence analysis of genes from a cDNA library of the scorpion Tityus discrepans Biochimie, 91, 1010-1019.
Kauferstein,S. Kendel,Y. Nicke,A. Coronas,F.I. Possani,L.D. Favreau,P. Krizaj,I. Wunder,C. Kauert,G. Mebs,D.
2009.
New conopeptides of the D-superfamily selectively inhibiting neuronal nicotinic acetylcholine receptors Toxicon, 54, 295-301.
Schwartz,E.F. Capes,E.M. Diego-Garcia,E. Zamudio,F.Z. Fuentes,O. Possani,L.D. Valdivia,H.H.
2009.
Characterization of hadrucalcin, a peptide from Hadrurus gertschi scorpion venom with pharmacological activity on ryanodine receptors Br.J Pharmacol., 157, 392-403.
Silva,E.C. Camargos,T.S. Maranhao,A.Q. Silva-Pereira,I. Silva,L.P. Possani,L.D. Schwartz,E.F.
2009.
Cloning and characterization of cDNA sequences encoding for new venom peptides of the Brazilian scorpion Opisthacanthus cayaporum Toxicon, 54, 252-261.
Corzo,G. Bernard,C. Clement,H. Villegas,E. Bosmans,F. Tytgat,J. Possani,L.D. Darbon,H. Alagon,A.
2009.
Insecticidal peptides from the theraposid spider Brachypelma albiceps: A NMR-based model of Ba2 Biochimica et Biophysica Acta (BBA), 1794, 1190-1196.
Gonzalez-Morales,L. Diego-Garcia,E. Segovia,L. Gutierrez,M.C. Possani,L.D.
2009.
Venom from the centipede Scolopendra viridis Say: purification, gene cloning and phylogenetic analysis of a phospholipase A2 Toxicon, 54, 8-15.
Prestipino,G. Corzo,G. Romeo,S. Murgia,A.R. Zanardi,I. Gurrola,G. Possani,L.D.
2009.
Scorpion toxins that block transient currents (IA) of rat cerebellum granular cells Toxicology Letters, 187, 1-9.
Espino-Solis,G.P. Riaño-Umbarila,L. Becerril,B. Possani,L.D.
2009.
Antidotes against venomous animals: State of the art and prospectives Journal of Proteomics, 72, 183-199.
Garcia-Gomez,B.I. Olamendi-Portugal,T.C. Paniagua,J. van der Walt,J. Dyason,K. Possani,L.D.
2009.
Heterologous expression of a gene that codes for Pg8, a scorpion toxin of Parabuthus granulatus, capable of generating protecting antibodies in mice Toxicon, 53, 770-778.
Petricevich,V.L. Reynaud,E. Cruz,A.H. Possani,L.D.
2008.
Macrophage activation, phagocytosis and intracellular calcium oscillations induced by scorpion toxins from Tityus serrulatus Clin Exp Immunol, 154, 415-423.
Corzo,G. Papp,F. Varga,Z. Barraza,O. Espino-Solis,P.G. Rodriguez de la Vega RC Gaspar,R. Panyi,G. Possani,L.D.
2008.
A selective blocker of Kv1.2 and Kv1.3 potassium channels from the venom of the scorpion Centruroides suffusus suffusus Biochem Pharmacol., 76, 1142-1154.
Carballar-Lejarazu,R. Rodriguez,M.H. De La Cruz Hernandez-Hernandez Ramos-Castaneda,J. Possani,L.D. Zurita-Ortega,M. Reynaud-Garza,E. Hernandez-Rivas,R. Loukeris,T. Lycett,G. Lanz-Mendoza,H.
2008.
Recombinant scorpine: a multifunctional antimicrobial peptide with activity against different pathogens Cell Mol Life Sci., 65, 3081-3092.
Abdel-Mottaleb,Y. Corzo,G. Martin-Eauclaire,M.F. Satake,H. Ceard,B. Peigneur,S. Nambaru,P. Bougis,P.E. Possani,L.D. Tytgat,J.
2008.
A common "hot spot" confers hERG blockade activity to alpha-scorpion toxins affecting K(+) channels Biochem Pharmacol., 76, 805-815.
Corzo,G. Diego-Garcia,E. Clement,H. Peigneur,S. Odell,G. Tytgat,J. Possani,L.D. Alagon,A.
2008.
An insecticidal peptide from the theraposid Brachypelma smithi spider venom reveals common molecular features among spider species from different genera Peptides, 29, 1901-1908.
Schwartz,E.F. Camargos,T.S. Zamudio,F.Z. Silva,L.P. Bloch,C., Jr. Caixeta,F. Schwartz,C.A. Possani,L.D.
2008.
Mass spectrometry analysis, amino acid sequence and biological activity of venom components from the Brazilian scorpion Opisthacanthus cayaporum Toxicon, 51, 1499-1508.
Olamendi-Portugal,T. Batista,C.V. Restano-Cassulini,R. Pando,V. Villa-Hernandez,O. Zavaleta-Martinez-Vargas,A. Salas-Arruz,M.C. de la Vega RC Becerril,B. Possani,L.D.
2008.
Proteomic analysis of the venom from the fish eating coral snake Micrurus surinamensis: Novel toxins, their function and phylogeny Proteomics, 8, 1919-1932.
Restano-Cassulini,R. Olamendi-Portugal,T. Zamudio,F. Becerril,B. Possani,L.D.
2008.
Two Novel Ergtoxins, Blockers of K(+)-channels, Purified from the Mexican Scorpion Centruroides elegans elegans Neurochem.Res, 33, 1525-1533.
Romeo,S. Corzo,G. Vasile,A. Satake,H. Prestipino,G. Possani,L.D.
2008.
A positive charge at the N-terminal segment of Discrepin increases the blocking effect of K(+) channels responsible for the I(A) currents in cerebellum granular cells Biochim Biophys Acta General Subjects, 1780, 750-755.
Espino-Solis,G.P. Osuna-Quintero,J. Possani,L.D.
2008.
Molecular cloning and characterization of the alphaX subunit from CD11c/CD18 horse Veterinary Immunology and Immunopathology, 122, 326-334.
Diego-Garcia,E. Abdel-Mottaleb,Y. Schwartz,E.F. de la Vega RC Tytgat,J. Possani,L.D.
2008.
Cytolytic and K(+) channel blocking activities of beta-KTx and scorpine-like peptides purified from scorpion venoms Cell Mol Life Sci., 65, 187-200.
Petricevich,V.L. Hernandez-Cruz,A. Coronas,F.I. Possani,L.D.
2007.
Toxin gamma from Tityus serrulatus scorpion venom plays an essential role in immunomodulation of macrophages. Toxicon, 50, 666-675.
Lopez-Vera,E. Aguilar,M.B. Schiavon,E. Marinzi,C. Ortiz,E. Restano Cassulini,R. Batista,C.V.F. Possani,L.D. Heimer de la Cotera,E.P. Peri,F. Becerril,B. Wanke,E.
2007.
Novel alpha-conotoxins from Conus spurius and the alpha-conotoxin EI share high-affinity potentiation and low-affinity inhibition of nicotinic acetylcholine receptors Febs Journal, 274, 3972-3985.
Estrada,G. Garcia,B.I. Schiavon,E. Ortiz,E. Cestele,S. Wanke,E. Possani,L.D. Corzo,G.
2007.
Four disulfide-bridged scorpion beta neurotoxin CssII: Heterologous expression and proper folding in vitro Biochimica et Biophysica Acta (BBA), 1770, 1161-1168.
Schwartz,E.F. Diego-Garcia,E. Rodriguez de la Vega RC Possani,L.D.
2007.
Transcriptome analysis of the venom gland of the Mexican scorpion Hadrurus gertschi (Arachnida: Scorpiones) BMC Genomics, 8, 119.
Valdez-Cruz,N.A. Segovia,L. Corona,M. Possani,L.D.
2007.
Sequence analysis and phylogenetic relationship of genes encoding heterodimeric Phospholipases A2 from the venom of the scorpion Anuroctonus phaiodactylus Gene, 396, 149-158.
Clement,H. Odell,G. Zamudio,F.Z. Redaelli,E. Wanke,E. Alagon,A. Possani,L.D.
2007.
Isolation and characterization of a novel toxin from the venom of the spider Grammostola rosea that blocks sodium channels Toxicon, 50, 65-74.
Batista,C.V. Roman-Gonzalez,S.A. Salas-Castillo,S.P. Zamudio,F.Z. Gomez-Lagunas,F. Possani,L.D.
2007.
Proteomic analysis of the venom from the scorpion Tityus stigmurus: Biochemical and physiological comparison with other Tityus species Comp Biochem Physiol C Toxicol.Pharmacol., 146, 147-157.
Diego-Garcia,E. Schwartz,E.F. D'Suze,G. Roman-Gonzalez,S.A. Batista,C.V. Garcia,B.I. Rodriguez-de-la-Vega,R. Possani,L.D.
2007.
Wide phylogenetic distribution of Scorpine and long-chain beta-KTx-like peptides in scorpion venoms: Identification of "orphan" components Peptides, 28, 31-37.
Rodriguez de la Vega RC Possani,L.D.
2007.
Novel paradigms on scorpion toxins that affect the activating mechanism of sodium channels Toxicon, 49, 171-180.
Garcia,M.L. Possani,L.D.
2007.
Gating modifier peptides of ion channels Toxicon, 49, 123.
Quintero-Hernandez,V. Juarez-Gonzalez,V.R. Ortiz-Leon,M. Sanchez,R. Possani,L.D. Becerril,B.
2007.
The change of the scFv into the Fab format improves the stability and in vivo toxin neutralization capacity of recombinant antibodies Mol.Immunol., 44, 1307-1315.
Schwartz,E.F. Schwartz,C.A. Gomez-Lagunas,F. Zamudio,F.Z. Possani,L.D.
2006.
HgeTx1, the first K(+)-channel specific toxin characterized from the venom of the scorpion Hadrurus gertschi Soleglad Toxicon, 48, 1046-1053.
Caliskan,F. Garcia,B.I. Coronas,F.I. Batista,C.V. Zamudio,F.Z. Possani,L.D.
2006.
Characterization of venom components from the scorpion Androctonus crassicauda of Turkey: Peptides and genes Toxicon, 48, 12-22.
Panyi,G. Possani,L.D. Rodriguez-de-la-Vega,R. Gaspar,R. Varga,Z.
2006.
K+ Channel Blockers: Novel Tools to Inhibit T Cell Activation Leading to Specific Immunosuppression Current Pharmaceutical Design, 12, 2199-2220.
Batista,C.V. D'Suze,G. Gomez-Lagunas,F. Zamudio,F.Z. Encarnacion,S. Sevcik,C. Possani,L.D.
2006.
Proteomic analysis of Tityus discrepans scorpion venom and amino acid sequence of novel toxins Proteomics, 6, 3718-3727.
Schiavon,E. Sacco,T. Restano,C.R. Gurrola,G. Tempia,F. Possani,L.D. Wanke,E.
2006.
Resurgent current and voltage sensor-trapping enhanced activation by a {beta}-scorpion toxin solely in nav1.6 channel: Significance in Mice Purkinje Neurons J.Biol.Chem., 281, 20326-20337.
Mebs,D. Kuch,U. Coronas,F.I. Batista,C.V. Gumprecht,A. Possani,L.D.
2006.
Biochemical and biological activities of the venom of the Chinese pitviper Zhaoermia mangshanensis, with the complete amino acid sequence and phylogenetic analysis of a novel Arg49 phospholipase A(2) myotoxin Toxicon, 47, 797-811.
Restano-Cassulini,R. Korolkova,Y.V. Diochot,S. Gurrola,G. Guasti,L. Possani,L. Lazdunski,M. Grishin,E. Arcangeli,A. Wanke,E.
2006.
Species Diversity and Peptide Toxins Blocking Selectivity of ERG Subfamily K+ Channels in CNS Mol Pharmacol., 69, 1673-1683.
Prochnicka-Chalufour,A. Corzo,G. Satake,H. Martin-Eauclaire,M.F. Murgia,A.R. Prestipino,G. D'Suze,G. Possani,L.D. Delepierre,M.
2006.
Solution Structure of Discrepin, a New K(+)-Channel Blocking Peptide from the alpha-KTx15 Subfamily(,) Biochemistry, 45, 1795-1804.
Abdel-Mottaleb,Y. Coronas,F.V. de Roodt,A.R. Possani,L.D. Tytgat,J.
2006.
A novel toxin from the venom of the scorpion Tityus trivittatus, is the first member of a new alpha-KTX subfamily FEBS Lett., 580, 592-596.
Barona,J. Batista,C.V. Zamudio,F.Z. Gomez-Lagunas,F. Wanke,E. Otero,R. Possani,L.D.
2006.
Proteomic analysis of the venom and characterization of toxins specific for Na(+)- and K(+)-channels from the Colombian scorpion Tityus pachyurus Biochimica et Biophysica Acta (BBA), 1764, 76-84.
Possani,L.D.
2005. Insecticidal peptide from scorpion venom.Industrial Bioprocessing, 27, 9-10.
Rodriguez de la Vega RC Possani,L.D.
2005.
Overview of scorpion toxins specific for Na(+) channels and related peptides: biodiversity, structure-function relationships and evolution Toxicon, 46, 831-844.
Aguilar,M.B. Lopez-Vera,E. Ortiz,E. Becerril,B. Possani,L.D. Olivera,B.M. Heimer de la Cotera,E.P.
2005.
A Novel Conotoxin from Conus delessertii with Posttranslationally Modified Lysine Residues Biochemistry, 44, 11130-11136.
Coronas,F.I. Balderas,C. Lopez,L.P. Possani,L.D. Gurrola,G.B.
2005. Amino acid sequence determination and chemical synthesis of CllErg1 (gamma-KTx1.5), a K+ channel blocker peptide isolated from the scorpion Centruroides limpidus limpidus Journal of the Brazilian Chemical Society, 16, 404-411.
Olamendi-Portugal,T. Somodi,S. Fernandez,J.A. Zamudio,F.Z. Becerril,B. Varga,Z. Panyi,G. Gaspar,R. Possani,L.D.
2005.
Novel alpha-KTx peptides from the venom of the scorpion Centruroides elegans selectively blockage Kv1.3 over IKCa1 K(+) channels of T cells Toxicon, 46, 418-429.
Padilla,A. Govezensky,T. Possani,L.D. Larralde,C.
2005.
Mortality and antibody responses of mice to three successive episodes of experimental scorpion (Centruroides limpidus limpidus) envenomation and immunological rescue Toxicon, 46, 142-149.
Rodriguez de la Vega RC Possani,L.D.
2005.
On the evolution of invertebrate defensins Trends Genet., 21, 330-332.
Riano-Umbarila,L. Juarez-Gonzalez,V.R. Olamendi-Portugal,T. Ortiz-Leon,M. Possani,L.D. Becerril,B.
2005.
A strategy for the generation of specific human antibodies by directed evolution and phage display FEBS J, 272, 2591-2601.
Gazarian,K.G. Gazarian,T. Hernandez,R. Possani,L.D.
2005.
Immunology of scorpion toxins and perspectives for generation of anti-venom vaccines Vaccine, 23, 3357-3368.
Juarez-Gonzalez,V.R. Riano-Umbarila,L. Quintero-Hernandez,V. Olamendi-Portugal,T. Ortiz-Leon,M. Ortiz,E. Possani,L.D. Becerril,B.
2005.
Directed Evolution, Phage Display and Combination of Evolved Mutants: A Strategy to Recover the Neutralization Properties of the scFv Version of BCF2 a Neutralizing Monoclonal Antibody Specific to Scorpion Toxin Cn2 J Mol Biol, 346, 1287-1297.
Diego-Garcia,E. Batista,C.V. Garcia-Gomez,B.I. Lucas,S. Candido,D.M. Gomez-Lagunas,F. Possani,L.D.
2005.
The Brazilian scorpion Tityus costatus Karsch: genes, peptides and function Toxicon, 45, 273-283.
Bagdaany,M. Batista,C.V. Valdez-Cruz,N.A. Somodi,S. Rodriguez de la Vega RC Licea,A.F. Varga,Z. Gaspar,R. Possani,L.D. Panyi,G.
2005.
Anuroctoxin, a new scorpion toxin of the {alpha}-KTx 6 subfamily is highly selective for Kv1.3 over IKCa1 ion channels of human T lymphocytes Mol Pharmacol., 67, 1034-1044.
Rodriguez-de-la-Vega,R. Barraza,R. Restano,R. Possani,L.D. 2009. Toxins active on Herg channel: structure and function, en: de Lima M.E. Animal toxins: State of the Art. Perspectives in Health and Biotechnology. Belo Horizonte. Universidad de Minas Gerais.
Possani-Postay,L.D. 2008. El estudio de los componentes del veneno de alacranes en el contexto de la biología molecular, la farmacología y la medicina en: Lopez-Munguia,A. Una ventana al quehacer científico. Instituto de Biotecnología de la UNAM 25 aniversario, cap 16. Mexico, D.F.. UNAM. pags. 179-187
Delepierre,M. Possani,L.D. 2006. Pharmaceutical Applications of Ion Channel Blockers: Use of NMR to Determine the Structure of Scorpion Toxins en: Webb,G.A. Modern Magnetic Resonance. Springer. pags. 1325-1330
Possani,L.D. Rodriguez de la Vega,R.C. 2006. Scorpion venom peptides en: Kastin,A. Handbook of Biologically Active Peptides. San Diego. Academic Press. pags. 339-354
L. Riaño, B. Becerril y L.D. Possani 2008 Human antibody variants that specifically recognize the toxin CN2 from Centruroides noxius scorpion venom. Estados Unidos.
M. Corona, M.C. García, N.A. Valdez, G. Gurrola, B. Becerril y L.D. Possani 2008 Recombinant Immunogens for the Generation of Antivenoms to the Venom of Scorpions of the Genus Centruroides.UNAM Estados Unidos.
B. I. García-Gómez, T. C. Olamendi-Gómez y L. D. Possani P 2008 Inmunógenos recombinantes para la producción de antivenenos contra el veneno de alacranes del género Parabuthus.UNAM México. (en trámite)
G.A.Corzo-Burguete, G. Estrada-Tapia, K. Hernández-Salgado, B. I. García-Gómez y L. D. Possani P 2008 Inmunógenos recombinantes para la producción de antivenenos contra el veneno de alacranes del género centruroides.UNAM México. (en trámite)
L. D. Possani P., G. Gurrola-Briones, S. P. Salas-Castillo, C. V. Ferreira B., Z. S. Varga, G. Panyi y R. Gaspar 2007 Vm23 and Vm24, two scorpion peptides that block human-T-lymphocyte potassium channels (sub-type Kv1.3) with high selectivity and decrease the in vivo DTH-responses in rats.UNAM Organización Mundial de la Propiedad Industrial. (en trámite)
L.D. Possani, F. Zamudio y A. Torres 2007 Hadrurina. Un péptido antibiótico.UNAM México.
L. Riaño U., B. Becerril L. y L. Possani P 2006 Variantes de anticuerpos humanos que reconocen específicamente a la toxina CN2 y al veneno del alacrán Centruroides noxius.UNAM México. (en trámite)
B. Becerril, F. Zamudio, B. Selisko, L.D. Possani, A. Ramírez y C. García 2005 Secuencia Primaria y ADNc de toxinas con actividad insecticida de alacranes del género Centruroides (Divisional).UNAM México.
Riaño L. , B. Becerril y L.D. Possani 2005 Human antibody variants that specifically recognize the toxin CN2 from Centruroides noxius scorpionon venom. Estados Unidos. (en trámite)
M. Corona, M.C. García, N.A. Valdez, G. Gurrola, B. Becerril , L.D. Possani 2003 Inmunógenos recombinantes para la generación de antivenenos contra el veneno de alacranes del género Centruroides. México. (en trámite)
B. Becerril, F. Zamudio, B. Selisko, L.D. Possani, A. Ramírez y C. García 2002 Secuencia Primaria y ADNc de toxinas con actividad insecticida de alacranes del género Centruroides.UNAM México.
A. Alagón C. L. D. Possani P., G. Gurrola B., E. V. Grishin, A. V. Lipkin y K. E. Volynski 2002 IImmunogen, Anti-Venom and Vaccine Against the Venom of the Black Widow Spider.UNAM 10/148,488, Europa EP00980069.9 y Canadá 2,397,731.
B. Selisko, C. García, A. Ramírez, F. Zamudio, B. Becerril y L.D. Possani 2001 Primary sequence and cDNA of insecticidally effective toxins from scorpions of the genus Centruroides.UNAM Estados Unidos.
L.D. Possani, B. Becerril y A.F. Licea N 2001 ADNc y fragmento Fab del anticuerpo BCF2 y su utilización en composiciones farmacéuticas neutralizantes de veneno de alacrán.UNAM México.
A. Alagón C., L. D. Possani P., G. Gurrola B., E. V. Grishin, A. V. Lipkin y K. E. Volynski 2000 Inmunógeno, anti-veneno y vacuna contra el veneno de la araña viuda negra.UNAM PCT.
C. Noeske-Jungblut, W.D. Schleuning, A. Alagon, L.D Possani, D.A. Cuevas-Aguirre, P. Donner, B. Haendler y U. Hechler 1999 Thormbin inhibitor from saliva protostomia.Schering Estados Unidos.
A. Alagón C., L. D. Possani P., G. Gurrola B., E. V. Grishin, A. V. Lipkin y K. E. Volynski 1999 Inmunógeno, anti-veneno y vacuna contra el veneno de la araña viuda negra.UNAM-Inst. de QuÍmica Bioorgánica México. (en trámite)
C. Noeske-jungbut B. Haendler J.R. kraestzschmar W.D. Schlenuning A. Alagon L.D. possani D.A Cuevas-Aguirre 1998 Collagen-induced platelet aggration inhibitor.Schering Estados Unidos.
C. Noeske-jungbut B. Haendler J.R. kraestzschmar W.D. Schlenuning A. Alagon L.D. possani D.A Cuevas-Aguirre 1998 Collagen-induced platelet aggration inhibitor.Schering Europa.
C. Noeske-jungbut B. Haendler J.R. kraestzschmar W.D. Schlenuning A. Alagon L.D. possani D.A Cuevas-Aguirre 1998 Collagen-induced platelet aggration inhibitor.Schering Europa.
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