Dr. Lourival Domingos Possani Postay Jefe de -Grupo Investigador Tutor de Maestría y Doctorado Nivel Inv. de Excelencia del SNI Departamento de Medicina Molecular y Bioprocesos Líneas de investigación email: possani @ibt.unam.mx Teléfonos (52+55) 562-27647 Local (52+777) 329-1647 red UNAM 27647 oficina (52+777) 311-4900 x 280 fax (52+55) 562-27657 Local (52+777) 329-1657 red UNAM 27657

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- Licenciatura: Historia Natural, Fac. de Filosofía de la Universidad Federal de Río Grande do Sul, Brasil (1966)
- Doctorado: en Biofísica, Faculte des Sciences D'Orsay-Universite de París, Francia (octubre 1968-marzo 1970)
- Mencion honorífica en examen de Doctorado (1970)
- Estancia de investigacion en la Universidad Rockefeller, New York, E.U.A. (julio 1971-septiembre 1973)

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Premio Redi International Society on Toxinology (2006)
Investigador emérito UNAM (2005)
Doctor Honoris Causa Universidad de Debrecen, Hungría (2005)
Miembro de la Academia de Ciencias de America Latina (1999)
Premio Nacional de Investigación Básica Fundación Glaxo-Wellcome (1998)
Howard Hughes Medical Institute International Research Scholar 1997-2001 (1997)
Premio Nacional de Ciencias y Artes Gobierno de la República (1995)
Premio de Investigacion Medica Dr. Jorge Rosenkran (1994)
Premio Universidad Nacional en el área de Ciencias Naturales UNAM (1993)
Howard Hughes Medical Institute International Research Scholar 1991-1996 (1991)

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Estudiantes

M.C. Juan Canul "¿Cómo reconoce un anticuerpo neutralizante a una toxina de alacrán? el caso de la interfaz entre el BCF2 y la CN2?"

Gerardo Pavel Espino "Desarrollo de anticuerpos contra integrinas de células dendríticas de caballo con miras a su aplicación biotecnológica"

M.C. Juana Jimenez "Toxinas de alacrán que afectan a canales de potasio del tipo HERG"

M.C. Itzel Amaro "Construcción y caracterización de una biblioteca de fragmentos variables de anticuerpos de cadena pesada de Lama glama desplegados en fagos"

Publicaciones recientes

de Roodt,A.R. Coronas,F.I. Lago,N. Gonzalez,M.E. Laskowicz,R.D. Beltramino,J.C. Saavedra,S. Lopez,R.A. Reati,G. Vucharchuk,M.G. Bazan,E. Varni,L. Salomon,O.D. Possani,L.D. 2009. General, biochemical and immunological characterization of the venom from the scorpion tityus trivittatus of argentina Toxicon Aug 22. [Epub ahead of print] .

Espino-Solis,G.P. Calderon-Amador,J. Calderon-Aranda,E.S. Licea,A.F. Donis-Maturano,L. Flores-Romo,L. Possani,L.D. 2009. Rational design of synthetic peptides to generate antibodies that recognize in situ CD11c+ putative dendritic cells in horse lymph nodes Veterinary Immunology and Immunopathology Jul 2. [Epub ahead of print] .

Corzo,G. Prochnicka-Chalufour,A. Garcia,B.I. Possani,L.D. Delepierre,M. 2009. Solution structure of Cn5, a crustacean toxin found in the venom of the scorpions Centruroides noxius and Centruroides suffusus suffusus Biochim Biophys Acta 1794 1591-1598.

Hernandez-Salgado,K. Estrada,G. Olvera,A. Coronas,F.I. Possani,L.D. Corzo,G. 2009. Heterologous expressed toxic and non-toxic peptide variants of toxin CssII are capable to produce neutralizing antibodies against the venom of the scorpion Centruroides suffusus suffusus Immunol Lett 125 93-99.

Papp,F. Batista,C.V. Varga,Z. Herceg,M. Roman-Gonzalez,S.A. Gaspar,R. Possani,L.D. Panyi,G. 2009. Tst26, a novel peptide blocker of Kv1.2 and Kv1.3 channels from the venom of Tityus stigmurus Toxicon 54 379-389.

D'Suze,G. Schwartz,E.F. Garcia,B.I. Sevcik,C. Possani,L.D. 2009. Molecular cloning and nucleotide sequence analysis of genes from a cDNA library of the scorpion Tityus discrepans Biochimie 91 1010-1019.

Kauferstein,S. Kendel,Y. Nicke,A. Coronas,F.I. Possani,L.D. Favreau,P. Krizaj,I. Wunder,C. Kauert,G. Mebs,D. 2009. New conopeptides of the D-superfamily selectively inhibiting neuronal nicotinic acetylcholine receptors Toxicon 54 295-301.

Schwartz,E.F. Capes,E.M. Diego-Garcia,E. Zamudio,F.Z. Fuentes,O. Possani,L.D. Valdivia,H.H. 2009. Characterization of hadrucalcin, a peptide from Hadrurus gertschi scorpion venom with pharmacological activity on ryanodine receptors Br.J Pharmacol. 157 392-403.

Silva,E.C. Camargos,T.S. Maranhao,A.Q. Silva-Pereira,I. Silva,L.P. Possani,L.D. Schwartz,E.F. 2009. Cloning and characterization of cDNA sequences encoding for new venom peptides of the Brazilian scorpion Opisthacanthus cayaporum Toxicon 54 252-261.

Corzo,G. Bernard,C. Clement,H. Villegas,E. Bosmans,F. Tytgat,J. Possani,L.D. Darbon,H. Alagon,A. 2009. Insecticidal peptides from the theraposid spider Brachypelma albiceps: A NMR-based model of Ba2 Biochimica et Biophysica Acta (BBA) 1794 1190-1196.

Gonzalez-Morales,L. Diego-Garcia,E. Segovia,L. Gutierrez,M.C. Possani,L.D. 2009. Venom from the centipede Scolopendra viridis Say: purification, gene cloning and phylogenetic analysis of a phospholipase A2 Toxicon 54 8-15.

Prestipino,G. Corzo,G. Romeo,S. Murgia,A.R. Zanardi,I. Gurrola,G. Possani,L.D. 2009. Scorpion toxins that block transient currents (IA) of rat cerebellum granular cells Toxicology Letters 187 1-9.

Espino-Solis,G.P. Riaño-Umbarila,L. Becerril,B. Possani,L.D. 2009. Antidotes against venomous animals: State of the art and prospectives Journal of Proteomics 72 183-199.

Garcia-Gomez,B.I. Olamendi-Portugal,T.C. Paniagua,J. van der Walt,J. Dyason,K. Possani,L.D. 2009. Heterologous expression of a gene that codes for Pg8, a scorpion toxin of Parabuthus granulatus, capable of generating protecting antibodies in mice Toxicon 53 770-778.

Petricevich,V.L. Reynaud,E. Cruz,A.H. Possani,L.D. 2008. Macrophage activation, phagocytosis and intracellular calcium oscillations induced by scorpion toxins from Tityus serrulatus Clin Exp Immunol 154 415-423.

Corzo,G. Papp,F. Varga,Z. Barraza,O. Espino-Solis,P.G. Rodriguez de la Vega RC Gaspar,R. Panyi,G. Possani,L.D. 2008. A selective blocker of Kv1.2 and Kv1.3 potassium channels from the venom of the scorpion Centruroides suffusus suffusus Biochem Pharmacol. 76 1142-1154.

Carballar-Lejarazu,R. Rodriguez,M.H. De La Cruz Hernandez-Hernandez Ramos-Castaneda,J. Possani,L.D. Zurita-Ortega,M. Reynaud-Garza,E. Hernandez-Rivas,R. Loukeris,T. Lycett,G. Lanz-Mendoza,H. 2008. Recombinant scorpine: a multifunctional antimicrobial peptide with activity against different pathogens Cell Mol Life Sci. 65 3081-3092.

Abdel-Mottaleb,Y. Corzo,G. Martin-Eauclaire,M.F. Satake,H. Ceard,B. Peigneur,S. Nambaru,P. Bougis,P.E. Possani,L.D. Tytgat,J. 2008. A common "hot spot" confers hERG blockade activity to alpha-scorpion toxins affecting K(+) channels Biochem Pharmacol. 76 805-815.

Corzo,G. Diego-Garcia,E. Clement,H. Peigneur,S. Odell,G. Tytgat,J. Possani,L.D. Alagon,A. 2008. An insecticidal peptide from the theraposid Brachypelma smithi spider venom reveals common molecular features among spider species from different genera Peptides 29 1901-1908.

Schwartz,E.F. Camargos,T.S. Zamudio,F.Z. Silva,L.P. Bloch,C., Jr. Caixeta,F. Schwartz,C.A. Possani,L.D. 2008. Mass spectrometry analysis, amino acid sequence and biological activity of venom components from the Brazilian scorpion Opisthacanthus cayaporum Toxicon 51 1499-1508.

Olamendi-Portugal,T. Batista,C.V. Restano-Cassulini,R. Pando,V. Villa-Hernandez,O. Zavaleta-Martinez-Vargas,A. Salas-Arruz,M.C. de la Vega RC Becerril,B. Possani,L.D. 2008. Proteomic analysis of the venom from the fish eating coral snake Micrurus surinamensis: Novel toxins, their function and phylogeny Proteomics 8 1919-1932.

Restano-Cassulini,R. Olamendi-Portugal,T. Zamudio,F. Becerril,B. Possani,L.D. 2008. Two Novel Ergtoxins, Blockers of K(+)-channels, Purified from the Mexican Scorpion Centruroides elegans elegans Neurochem.Res 33 1525-1533.

Romeo,S. Corzo,G. Vasile,A. Satake,H. Prestipino,G. Possani,L.D. 2008. A positive charge at the N-terminal segment of Discrepin increases the blocking effect of K(+) channels responsible for the I(A) currents in cerebellum granular cells Biochim Biophys Acta General Subjects 1780 750-755.

Espino-Solis,G.P. Osuna-Quintero,J. Possani,L.D. 2008. Molecular cloning and characterization of the alphaX subunit from CD11c/CD18 horse Veterinary Immunology and Immunopathology 122 326-334.

Diego-Garcia,E. Abdel-Mottaleb,Y. Schwartz,E.F. de la Vega RC Tytgat,J. Possani,L.D. 2008. Cytolytic and K(+) channel blocking activities of beta-KTx and scorpine-like peptides purified from scorpion venoms Cell Mol Life Sci. 65 187-200.

Petricevich,V.L. Hernandez-Cruz,A. Coronas,F.I. Possani,L.D. 2007. Toxin gamma from Tityus serrulatus scorpion venom plays an essential role in immunomodulation of macrophages. Toxicon 50 666-675.

Lopez-Vera,E. Aguilar,M.B. Schiavon,E. Marinzi,C. Ortiz,E. Restano Cassulini,R. Batista,C.V.F. Possani,L.D. Heimer de la Cotera,E.P. Peri,F. Becerril,B. Wanke,E. 2007. Novel alpha-conotoxins from Conus spurius and the alpha-conotoxin EI share high-affinity potentiation and low-affinity inhibition of nicotinic acetylcholine receptors Febs Journal 274 3972-3985.

Estrada,G. Garcia,B.I. Schiavon,E. Ortiz,E. Cestele,S. Wanke,E. Possani,L.D. Corzo,G. 2007. Four disulfide-bridged scorpion beta neurotoxin CssII: Heterologous expression and proper folding in vitro Biochimica et Biophysica Acta (BBA) 1770 1161-1168.

Schwartz,E.F. Diego-Garcia,E. Rodriguez de la Vega RC Possani,L.D. 2007. Transcriptome analysis of the venom gland of the Mexican scorpion Hadrurus gertschi (Arachnida: Scorpiones) BMC Genomics 8 119.

Valdez-Cruz,N.A. Segovia,L. Corona,M. Possani,L.D. 2007. Sequence analysis and phylogenetic relationship of genes encoding heterodimeric Phospholipases A2 from the venom of the scorpion Anuroctonus phaiodactylus Gene 396 149-158.

Clement,H. Odell,G. Zamudio,F.Z. Redaelli,E. Wanke,E. Alagon,A. Possani,L.D. 2007. Isolation and characterization of a novel toxin from the venom of the spider Grammostola rosea that blocks sodium channels Toxicon 50 65-74.

Batista,C.V. Roman-Gonzalez,S.A. Salas-Castillo,S.P. Zamudio,F.Z. Gomez-Lagunas,F. Possani,L.D. 2007. Proteomic analysis of the venom from the scorpion Tityus stigmurus: Biochemical and physiological comparison with other Tityus species Comp Biochem Physiol C Toxicol.Pharmacol. 146 147-157.

Diego-Garcia,E. Schwartz,E.F. D'Suze,G. Roman-Gonzalez,S.A. Batista,C.V. Garcia,B.I. Rodriguez-de-la-Vega,R. Possani,L.D. 2007. Wide phylogenetic distribution of Scorpine and long-chain beta-KTx-like peptides in scorpion venoms: Identification of "orphan" components Peptides 28 31-37.

Rodriguez de la Vega RC Possani,L.D. 2007. Novel paradigms on scorpion toxins that affect the activating mechanism of sodium channels Toxicon 49 171-180.

Garcia,M.L. Possani,L.D. 2007. Gating modifier peptides of ion channels Toxicon 49 123.

Quintero-Hernandez,V. Juarez-Gonzalez,V.R. Ortiz-Leon,M. Sanchez,R. Possani,L.D. Becerril,B. 2007. The change of the scFv into the Fab format improves the stability and in vivo toxin neutralization capacity of recombinant antibodies Mol.Immunol. 44 1307-1315.

Schwartz,E.F. Schwartz,C.A. Gomez-Lagunas,F. Zamudio,F.Z. Possani,L.D. 2006. HgeTx1, the first K(+)-channel specific toxin characterized from the venom of the scorpion Hadrurus gertschi Soleglad Toxicon 48 1046-1053.

Caliskan,F. Garcia,B.I. Coronas,F.I. Batista,C.V. Zamudio,F.Z. Possani,L.D. 2006. Characterization of venom components from the scorpion Androctonus crassicauda of Turkey: Peptides and genes Toxicon 48 12-22.

Panyi,G. Possani,L.D. Rodriguez-de-la-Vega,R. Gaspar,R. Varga,Z. 2006. K+ Channel Blockers: Novel Tools to Inhibit T Cell Activation Leading to Specific Immunosuppression Current Pharmaceutical Design 12 2199-2220.

Batista,C.V. D'Suze,G. Gomez-Lagunas,F. Zamudio,F.Z. Encarnacion,S. Sevcik,C. Possani,L.D. 2006. Proteomic analysis of Tityus discrepans scorpion venom and amino acid sequence of novel toxins Proteomics 6 3718-3727.

Schiavon,E. Sacco,T. Restano,C.R. Gurrola,G. Tempia,F. Possani,L.D. Wanke,E. 2006. Resurgent current and voltage sensor-trapping enhanced activation by a {beta}-scorpion toxin solely in nav1.6 channel: Significance in Mice Purkinje Neurons J.Biol.Chem. 281 20326-20337.

Mebs,D. Kuch,U. Coronas,F.I. Batista,C.V. Gumprecht,A. Possani,L.D. 2006. Biochemical and biological activities of the venom of the Chinese pitviper Zhaoermia mangshanensis, with the complete amino acid sequence and phylogenetic analysis of a novel Arg49 phospholipase A(2) myotoxin Toxicon 47 797-811.

Restano-Cassulini,R. Korolkova,Y.V. Diochot,S. Gurrola,G. Guasti,L. Possani,L. Lazdunski,M. Grishin,E. Arcangeli,A. Wanke,E. 2006. Species Diversity and Peptide Toxins Blocking Selectivity of ERG Subfamily K+ Channels in CNS Mol Pharmacol. 69 1673-1683.

Prochnicka-Chalufour,A. Corzo,G. Satake,H. Martin-Eauclaire,M.F. Murgia,A.R. Prestipino,G. D'Suze,G. Possani,L.D. Delepierre,M. 2006. Solution Structure of Discrepin, a New K(+)-Channel Blocking Peptide from the alpha-KTx15 Subfamily(,) Biochemistry 45 1795-1804.

Abdel-Mottaleb,Y. Coronas,F.V. de Roodt,A.R. Possani,L.D. Tytgat,J. 2006. A novel toxin from the venom of the scorpion Tityus trivittatus, is the first member of a new alpha-KTX subfamily FEBS Lett. 580 592-596.

Barona,J. Batista,C.V. Zamudio,F.Z. Gomez-Lagunas,F. Wanke,E. Otero,R. Possani,L.D. 2006. Proteomic analysis of the venom and characterization of toxins specific for Na(+)- and K(+)-channels from the Colombian scorpion Tityus pachyurus Biochimica et Biophysica Acta (BBA) 1764 76-84.

Possani,L.D. 2005. Insecticidal peptide from scorpion venom.Industrial Bioprocessing 27 9-10.

Rodriguez de la Vega RC Possani,L.D. 2005. Overview of scorpion toxins specific for Na(+) channels and related peptides: biodiversity, structure-function relationships and evolution Toxicon 46 831-844.

Aguilar,M.B. Lopez-Vera,E. Ortiz,E. Becerril,B. Possani,L.D. Olivera,B.M. Heimer de la Cotera,E.P. 2005. A Novel Conotoxin from Conus delessertii with Posttranslationally Modified Lysine Residues Biochemistry 44 11130-11136.

Coronas,F.I. Balderas,C. Lopez,L.P. Possani,L.D. Gurrola,G.B. 2005. Amino acid sequence determination and chemical synthesis of CllErg1 (gamma-KTx1.5), a K+ channel blocker peptide isolated from the scorpion Centruroides limpidus limpidus Journal of the Brazilian Chemical Society 16 404-411.

Olamendi-Portugal,T. Somodi,S. Fernandez,J.A. Zamudio,F.Z. Becerril,B. Varga,Z. Panyi,G. Gaspar,R. Possani,L.D. 2005. Novel alpha-KTx peptides from the venom of the scorpion Centruroides elegans selectively blockage Kv1.3 over IKCa1 K(+) channels of T cells Toxicon 46 418-429.

Padilla,A. Govezensky,T. Possani,L.D. Larralde,C. 2005. Mortality and antibody responses of mice to three successive episodes of experimental scorpion (Centruroides limpidus limpidus) envenomation and immunological rescue Toxicon 46 142-149.

Rodriguez de la Vega RC Possani,L.D. 2005. On the evolution of invertebrate defensins Trends Genet. 21 330-332.

Riano-Umbarila,L. Juarez-Gonzalez,V.R. Olamendi-Portugal,T. Ortiz-Leon,M. Possani,L.D. Becerril,B. 2005. A strategy for the generation of specific human antibodies by directed evolution and phage display FEBS J 272 2591-2601.

Gazarian,K.G. Gazarian,T. Hernandez,R. Possani,L.D. 2005. Immunology of scorpion toxins and perspectives for generation of anti-venom vaccines Vaccine 23 3357-3368.

Juarez-Gonzalez,V.R. Riano-Umbarila,L. Quintero-Hernandez,V. Olamendi-Portugal,T. Ortiz-Leon,M. Ortiz,E. Possani,L.D. Becerril,B. 2005. Directed Evolution, Phage Display and Combination of Evolved Mutants: A Strategy to Recover the Neutralization Properties of the scFv Version of BCF2 a Neutralizing Monoclonal Antibody Specific to Scorpion Toxin Cn2 J Mol Biol 346 1287-1297.

Diego-Garcia,E. Batista,C.V. Garcia-Gomez,B.I. Lucas,S. Candido,D.M. Gomez-Lagunas,F. Possani,L.D. 2005. The Brazilian scorpion Tityus costatus Karsch: genes, peptides and function Toxicon 45 273-283.

Bagdaany,M. Batista,C.V. Valdez-Cruz,N.A. Somodi,S. Rodriguez de la Vega RC Licea,A.F. Varga,Z. Gaspar,R. Possani,L.D. Panyi,G. 2005. Anuroctoxin, a new scorpion toxin of the {alpha}-KTx 6 subfamily is highly selective for Kv1.3 over IKCa1 ion channels of human T lymphocytes Mol Pharmacol. 67 1034-1044.

Valdez-Cruz,N.A. Batista,C.V. Zamudio,F.Z. Bosmans,F. Tytgat,J. Possani,L.D. 2004. Phaiodotoxin, a novel structural class of insect-toxin isolated from the venom of the Mexican scorpion Anuroctonus phaiodactylus Eur.J Biochem 271 4753-4761.

D'Suze,G. Batista,C.V. Frau,A. Murgia,A.R. Zamudio,F.Z. Sevcik,C. Possani,L.D. Prestipino,G. 2004. Discrepin, a new peptide of the sub-family alpha-ktx15, isolated from the scorpion Tityus discrepans irreversibly blocks K(+)-channels (I(A) currents) of cerebellum granular cells Arch.Biochem Biophys. 430 256-263.

Valdez-Cruz,N.A. Davila,S. Licea,A. Corona,M. Zamudio,F.Z. Garcia-Valdes,J. Boyer,L. Possani,L.D. 2004. Biochemical, genetic and physiological characterization of venom components from two species of scorpions: Centruroides exilicauda Wood and Centruroides sculpturatus Ewing Biochimie 86 387-396.

Frenal,K. Xu,C.Q. Wolff,N. Wecker,K. Gurrola,G.B. Zhu,S.Y. Chi,C.W. Possani,L.D. Tytgat,J. Delepierre,M. 2004. Exploring structural features of the interaction between the scorpion toxinCnErg1 and ERG K(+) channels Proteins 56 367-375.

Rodriguez-de-la-Vega,R. Possani,L.D. 2004. Current views on scorpion toxins specific for K(+)-channels Toxicon 43 865-875.

Rodriguez-de-la-Vega,R. Garcia,B. D'Ambrosio,C. Diego-Garcia,E. Scaloni,A. Possani,L.D. 2004. Antimicrobial peptide induction in the haemolymph of the Mexican scorpion Centruroides limpidus limpidus in response to septic injury Cell Mol Life Sci 61 1507-1519.

Rio-Portilla,F. Hernandez-Marin,E. Pimienta,G. Coronas,F.V. Zamudio,F.Z. Rodriguez-de-la-Vega,R. Wanke,E. Possani,L.D. 2004. NMR solution structure of Cn12, a novel peptide from the Mexican scorpion Centruroides noxius with a typical beta-toxin sequence but with alpha-like physiological activity Eur.J Biochem 271 2504-2516.

Murgia,A.R. Batista,C.V. Prestipino,G. Possani,L.D. 2004. Amino acid sequence and function of a new alpha-toxin from the Amazonian scorpion Tityus cambridgei Toxicon 43 737-740.

Valdez-Cruz,N.A. Batista,C.V. Possani,L.D. 2004. Phaiodactylipin, a glycosylated heterodimeric phospholipase A from the venom of the scorpion Anuroctonus phaiodactylus Eur.J Biochem 271 1453-1464.

Zhu,X. Zamudio,F.Z. Olbinski,B.A. Possani,L.D. Valdivia,H.H. 2004. Activation of skeletal ryanodine receptors by two novel scorpion toxins from buthotus judaicus J Biol Chem 279 26588-26596.

Montero-Solis,C. Gonzalez-Ceron,L. Rodriguez,M.H. Cirerol,B.E. Zamudio,F. Possanni,L.D. James,A.A. De La Cruz Hernandez-Hernandez,F. 2004. Identification and characterization of gp65, a salivary-gland-specific molecule expressed in the malaria vector Anopheles albimanus Insect Mol.Biol 13 155-164.

Selisko,B. Cosio,G. Garcia,C. Becerril,B. Possani,L.D. Horjales,E. 2004. Bacterial expression, purification and functional characterization of a recombinant chimeric Fab derived from murine mAb BCF2 that neutralizes the venom of the scorpion Centruroides noxius hoffmann Toxicon 43 43-51.

D'Suze,G. Sevcik,C. Corona,M. Zamudio,F.Z. Batista,C.V. Coronas,F.I. Possani,L.D. 2004. Ardiscretin a novel arthropod-selective toxin from Tityus discrepans scorpion venom Toxicon 43 263-272.

Batista,C.V. Del Pozo,L. Zamudio,F.Z. Contreras,S. Becerril,B. Wanke,E. Possani,L.D. 2004. Proteomics of the venom from the Amazonian scorpion Tityus cambridgei and the role of prolines on mass spectrometry analysis of toxins J Chromatogr B Analyt.Technol Biomed Life Sci 803 55-66.

Gomez-Lagunas,F. Batista,C.V. Olamendi-Portugal,T. Ramirez-Dominguez,M.E. Possani,L.D. 2004. Inhibition of the collapse of the shaker k+ conductance by specific scorpion toxins J Gen.Physiol 123 265-279.

Pascual,I. Gil-Parrado,S. Cisneros,M. Joseph-Bravo,P. Diaz,J. Possani,L.D. Charli,J.L. Chavez,M. 2004. Purification of a specific inhibitor of pyroglutamyl aminopeptidase II from the marine annelide Hermodice carunculata. In vivo effects in rodent brain Int J Biochem Cell Biol 36 138-152.

Shalabi,A. Zamudio,F. Wu,X. Scaloni,A. Possani,L. Villereal,M.L. 2004. Tetrapandins, a new class of scorpion toxins that specifically inhibit store-operated calcium entry in HEK-293 cells J Biol Chem 279 1040-1049.

Huys,I. Olamendi-Portugal,T. Garcia-Gomez,B.I. Vandenberghe,I. Van Beeumen,J. Dyason,K. Clynen,E. Zhu,S. van der Walt,J. Possani,L. Tytgat,J. 2004. A subfamily of acidic alpha -K+ toxins J Biol Chem 279 2781-2789.

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Libros y capítulos recientes

Rodriguez-de-la-Vega,R. Barraza,R. Restano,R. Possani,L.D. 2009. Toxins active on Herg channel: structure and function, en: de Lima M.E. Animal toxins: State of the Art. Perspectives in Health and Biotechnology. Belo Horizonte. Universidad de Minas Gerais. in press

Possani-Postay,L.D. 2008. El estudio de los componentes del veneno de alacranes en el contexto de la biología molecular, la farmacología y la medicina en: Lopez-Munguia,A. Una ventana al quehacer científico. Instituto de Biotecnología de la UNAM 25 aniversario, cap 16. Mexico, D.F.. UNAM. pags. 179-187

Delepierre,M. Possani,L.D. 2006. Pharmaceutical Applications of Ion Channel Blockers: Use of NMR to Determine the Structure of Scorpion Toxins en: Webb,G.A. Modern Magnetic Resonance. Springer. pags. 1325-1330

Possani,L.D. Rodriguez de la Vega,R.C. 2006. Scorpion venom peptides en: Kastin,A. Handbook of Biologically Active Peptides. San Diego. Academic Press. pags. 339-354

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Patentes

L. Riaño, B. Becerril y L.D. Possani 2008 Human antibody variants that specifically recognize the toxin CN2 from Centruroides noxius scorpion venom. Estados Unidos.

M. Corona, M.C. García, N.A. Valdez, G. Gurrola, B. Becerril y L.D. Possani 2008 Recombinant Immunogens for the Generation of Antivenoms to the Venom of Scorpions of the Genus Centruroides.UNAM Estados Unidos.

B. I. García-Gómez, T. C. Olamendi-Gómez y L. D. Possani P 2008 Inmunógenos recombinantes para la producción de antivenenos contra el veneno de alacranes del género Parabuthus.UNAM México. (en trámite)

G.A.Corzo-Burguete, G. Estrada-Tapia, K. Hernández-Salgado, B. I. García-Gómez y L. D. Possani P 2008 Inmunógenos recombinantes para la producción de antivenenos contra el veneno de alacranes del género centruroides.UNAM México. (en trámite)

L. D. Possani P., G. Gurrola-Briones, S. P. Salas-Castillo, C. V. Ferreira B., Z. S. Varga, G. Panyi y R. Gaspar 2007 Vm23 and Vm24, two scorpion peptides that block human-T-lymphocyte potassium channels (sub-type Kv1.3) with high selectivity and decrease the in vivo DTH-responses in rats.UNAM Organización Mundial de la Propiedad Industrial. (en trámite)

L.D. Possani, F. Zamudio y A. Torres 2007 Hadrurina. Un péptido antibiótico.UNAM México.

L. Riaño U., B. Becerril L. y L. Possani P 2006 Variantes de anticuerpos humanos que reconocen específicamente a la toxina CN2 y al veneno del alacrán Centruroides noxius.UNAM México. (en trámite)

B. Becerril, F. Zamudio, B. Selisko, L.D. Possani, A. Ramírez y C. García 2005 Secuencia Primaria y ADNc de toxinas con actividad insecticida de alacranes del género Centruroides (Divisional).UNAM México.

Riaño L. , B. Becerril y L.D. Possani 2005 Human antibody variants that specifically recognize the toxin CN2 from Centruroides noxius scorpionon venom. Estados Unidos. (en trámite)

M. Corona, M.C. García, N.A. Valdez, G. Gurrola, B. Becerril , L.D. Possani 2003 Inmunógenos recombinantes para la generación de antivenenos contra el veneno de alacranes del género Centruroides. México. (en trámite)

B. Becerril, F. Zamudio, B. Selisko, L.D. Possani, A. Ramírez y C. García 2002 Secuencia Primaria y ADNc de toxinas con actividad insecticida de alacranes del género Centruroides.UNAM México.

A. Alagón C. L. D. Possani P., G. Gurrola B., E. V. Grishin, A. V. Lipkin y K. E. Volynski 2002 IImmunogen, Anti-Venom and Vaccine Against the Venom of the Black Widow Spider.UNAM 10/148,488, Europa EP00980069.9 y Canadá 2,397,731.

B. Selisko, C. García, A. Ramírez, F. Zamudio, B. Becerril y L.D. Possani 2001 Primary sequence and cDNA of insecticidally effective toxins from scorpions of the genus Centruroides.UNAM Estados Unidos.

L.D. Possani, B. Becerril y A.F. Licea N 2001 ADNc y fragmento Fab del anticuerpo BCF2 y su utilización en composiciones farmacéuticas neutralizantes de veneno de alacrán.UNAM México.

A. Alagón C., L. D. Possani P., G. Gurrola B., E. V. Grishin, A. V. Lipkin y K. E. Volynski 2000 Inmunógeno, anti-veneno y vacuna contra el veneno de la araña viuda negra.UNAM PCT.

C. Noeske-Jungblut, W.D. Schleuning, A. Alagon, L.D Possani, D.A. Cuevas-Aguirre, P. Donner, B. Haendler y U. Hechler 1999 Thormbin inhibitor from saliva protostomia.Schering Estados Unidos.

A. Alagón C., L. D. Possani P., G. Gurrola B., E. V. Grishin, A. V. Lipkin y K. E. Volynski 1999 Inmunógeno, anti-veneno y vacuna contra el veneno de la araña viuda negra.UNAM-Inst. de QuÍmica Bioorgánica México. (en trámite)

C. Noeske-jungbut B. Haendler J.R. kraestzschmar W.D. Schlenuning A. Alagon L.D. possani D.A Cuevas-Aguirre 1998 Collagen-induced platelet aggration inhibitor.Schering Estados Unidos.

C. Noeske-jungbut B. Haendler J.R. kraestzschmar W.D. Schlenuning A. Alagon L.D. possani D.A Cuevas-Aguirre 1998 Collagen-induced platelet aggration inhibitor.Schering Europa.

C. Noeske-jungbut B. Haendler J.R. kraestzschmar W.D. Schlenuning A. Alagon L.D. possani D.A Cuevas-Aguirre 1998 Collagen-induced platelet aggration inhibitor.Schering Europa.

C. Noeske-jungblut W.D. Schelunig A. Alagon L.D. Possani D.A. Cuevas-Aguirre P. Donner B. Haendler U. Hechler 1997 Clotting inhibitor made from protostomia saliva.Schering Europa.

L.D. Possani, B. Becerril, M. Corona, F. Ingerborg, F. Zamudio, E.S. Calderón, P. Litton y B.M. Martin 1995 Producao de peptideos de escorpioes Tityus serrulatus, Tityus bahiensis e Tityus stigmurus, e respectiva inmunizacao de cavalo, visando a obtencao de soros antiescorpionicos.UNAM-Fundación Butantan Brasil.

L.D. Possani P. G. Gurrola B. M.A.A. Bayón C. M. Sitges B. 1991 Procedimiento, diseÒo y síntesis para la obtención de péptidos sintéticos de estructura (Ax)N-(As)N-As, capaces de formar derivados beta-carbonilos para sustratos fluorogénicos de enzimas hidrolasas.UNAM México. (en trámite)

L D. Possani P. G. Gurrola B. M. A. A. Bayón C y M. Sitges B. 1990 Synthetic Noxiustoxin related peptides.UNAM Estados Unidos.