Instituto de Biotecnologia UNAM

IBT-UNAM : Dr. Jean-Louis Joseph Marie Charli Casalonga

Dr.

Dr. Jean-Louis Joseph Marie Charli Casalonga


Jefe del Departamento Genética del Desarrollo y Fisiología Molecular

Líder Académico »» Grupo

Investigador

Tutor de Maestría y Doctorado

Nivel III del SNI

Líneas de investigación

email: charli@ibt.unam.mx

Teléfonos

Oficina +52 (777) 329-1633
desde la CDMX 562-27633

red UNAM 27633
Fax +52 (777) 3170805

Laboratorio +52 (777) 329-1620
desde la CDMX 562-27620

red UNAM 27620


- Licenciatura: Matematicas Superiores y Especiales, Liceo Paul Varely (1971) y Química-Biología, Universidad de París VII, Francia (1973)
- Maestría: en Ciencias Fisiologicas y Biología, Universidad de París XII, Francia (1975)
- Doctorado: en Ciencias Naturales (Biofísica), Universidad de París VI, Francia (1978)
- Estancia de Investigación: Laboratorio del Dres. J.F. McKelvy y L. Hersh, de la Universidad de Texas, Centro de Ciencias de la Salud, Departamento de Bioquímica, Dallas, Texas, E.U.A. (1978-1979)
- Estancia de Investigación: Laboratorio del Dr. H. Boyler, de la Universidad de California, Departamento de Bioquímica y Biofísica, en San Francisco, CA, E.U.A. (1979-1980)


Premio de la Academia de la Investigación Científica en el área de Ciencias Naturales (1990)


Estudiantes

M.C. Adair Jonathan Rodriguez

M.C. Ana Elena Castro

Yuvizel Mariela Rivera

Lic. Haydn Esau Urbina

M.C. Karla Yamili Vargas

Publicaciones recientes

Pascual-Alonso,I. Rivera-Mendez,L. Almeida,F. Valdes-Tresanco,M.E. Arrebola-Sanchez,Y. Hernandez-Zanuy,A. Alvarez-Lajonchere,L. Diaz,D. Sanchez,B. Florent,I. Schmitt,M. Cisneros,M. Charli,J.L. 2020. Marine organisms: a source of biomedically relevant M1, M2 and M17 exopeptidase inhibitors Revista Cubana de Ciencias Biológicas, 8, 1-36.

Rivera-Mendez,L. Arrebola,Y. Valdes-Tresanco,M.E. Diaz-Guevara,L. Bergado,G. Sanchez,B. Charli,J.L. Pascual-Alonso,I. 2020. Bestatin and bacitracin inhibit porcine kidney cortex dipeptidyl peptidase IV activity and reduce human melanoma MeWo cell viability International Journal of Biological Macromolecules, 164, 2944-2952.

Castillo-Campos,A. Gutierrez-Mata,A. Charli,J.L. Joseph-Bravo,P. 2020. Chronic stress inhibits hypothalamus-pituitary-thyroid axis and brown adipose tissue responses to acute cold exposure in male rats Journal of Endocrinological Investigation, 30 July online first, .

Pascual-Alonso,I. Rivera-Mendez,L. Valdes-Tresanco,M.E. Bounaadja,L. Schmitt.M. Arrebola-Sanchez,Y. Alvarez-Lajonchere,L. Charli,J.L. Florent,I. 2020. Biochemical evidences for M1-, M17- and M18-like aminopeptidases in marine invertebrates from Cuban coastline Zeitschrift für Naturforschung C, 29 Jun Ahead of print, .

Charli,J.L. Rodriguez-Rodriguez,A. Hernandez-Ortega,K. Cote-Velez,A. Uribe,R.M. Jaimes-Hoy,L. Joseph-Bravo,P. 2020. The Thyrotropin-Releasing Hormone-Degrading Ectoenzyme, a Therapeutic Target? Frontiers in Pharmacology, 11, 640.

Joseph-Bravo,P. Lazcano,I. Jaimes-Hoy,L. Gutierrez-Mariscal,M. Sanchez-Jaramillo,E. Uribe,R.M. Charli,J.L. 2020. Sexually dimorphic dynamics of thyroid axis activity during fasting in rats Frontiers in Bioscience, Landmark, 25, 1305-1323.

Farkas,E. Varga,E. Kovacs,B. Szilvasy-Szabo,A. Cote-Velez,A. Peterfi,Z. Matziari,M. Toth,M. Zelena,D. Mezriczky,Z. Kadar,A. Kovari,D. Watanabe,M. Kano,M. Mackie,K. Rozsa,B. Ruska,Y. Toth,B. Mate,Z. Erdelyi,F. Szabo,G. Gereben,B. Lechan,R.M. Charli,J.L. Joseph-Bravo,P. Fekete,C. 2020. A glial-neuronal circuit in the median eminence regulates thyrotropin-releasing hormone-release via the endocannabinoid system iScience, 23, 100921.

Pascual-Alonso,I. Alonso-Bosch,R. Cabrera-Munoz,A. Perera,W. Charli,J.L. 2019. Methanolic extracts of paratoid gland secretion from Cuban Peltophryne toads contain inhibitory activities against peptidases with biomedical relevance Biotecnologia Aplicada, 36, 2221-2227.

Arrebola,Y. Rivera,L. Pedroso,A. McGuire,R. Tresanco,M.E.V. Bergado,G. Charli,J.L. Sanchez,B. Pascual-Alonso,I. 2019. Bacitracin is a non-competitive inhibitor of porcine M1 family neutral and glutamyl aminopeptidases Natural Product Research, Oct 25 [Epub ahead of print], .

Jaimes-Hoy,L. Romero,F. Charli,J.L. Joseph-Bravo,P. 2019. Sex Dimorphic Responses of the Hypothalamus-Pituitary-Thyroid Axis to Maternal Separation and Palatable Diet Frontiers in Endocrinology, 10, 445.

Rodriguez-Rodriguez,A. Lazcano,I. Sanchez-Jaramillo,E. Uribe,R.M. Jaimes-Hoy,L. Joseph-Bravo,P. Charli,J.L. 2019. Tanycytes and the Control of Thyrotropin-Releasing Hormone Flux Into Portal Capillaries Frontiers in Endocrinology, 10, 401.

Parra-Montes de Oca,M.A. Gutierrez-Mariscal,M. Salmeron-Jimenez,M.F. Jaimes-Hoy,L. Charli,J.L. Joseph-Bravo,P. 2019. Voluntary Exercise-Induced Activation of Thyroid Axis and Reduction of White Fat Depots Is Attenuated by Chronic Stress in a Sex Dimorphic Pattern in Adult Rats Frontiers in Endocrinology, 10, 418.

Pascual,I. Valiente,P.A. Garcia,G. Valdes-Tresanco,M.E. Arrebola,Y. Diaz,L. Bounaadja,L. Uribe,R.M. Pacheco,M.C. Florent,I. Charli,J.L. 2017. Discovery of novel non-competitive inhibitors of mammalian neutral M1 aminopeptidase (APN) Biochimie, 142, 216-225.

Jaimes-Hoy,L. Gurrola,G.B. Cisneros,M. Joseph-Bravo,P. Possani,L.D. Charli,J.L. 2017. The Kv1.3 channel blocker Vm24 enhances muscle glucose transporter 4 mobilization but does not reduce body-weight gain in diet-induced obese male rats Life Sciences, 181, 23-30.

Cote-Velez,A. Martinez-Baez A. Lezama,L. Uribe,R.M. Joseph-Bravo,P. Charli,J.L. 2017. A screen for modulators reveals that orexin-A rapidly stimulates thyrotropin releasing hormone expression and release in hypothalamic cell culture Neuropeptides, 62, 11-20.

Sotelo-Rivera,I. Cote-Velez,A. Uribe,R.M. Charli,J.L. Joseph-Bravo,P. 2017. Glucocorticoids curtail stimuli-induced CREB phosphorylation in TRH neurons through interaction of the glucocorticoid receptor with the catalytic subunit of protein kinase A Endocrine, 55, 861-871.

Joseph-Bravo,P. Jaimes-Hoy,L. Charli,J.L. 2016. Advances in TRH signaling Reviews in Endocrine and Metabolic Disorders, 17, 545-558.

Jaimes-Hoy,L. Gutierrez-Mariscal,M. Vargas,Y. Perez-Maldonado,A. Romero,F. Sanchez-Jaramillo,E. Charli,J.L. Joseph-Bravo,P. 2016. Neonatal maternal separation alters, in a sex specific manner, the expression of TRH, of TRH-degrading ectoenzyme in the rat hypothalamus, and the response of the thyroid axis to starvation Endocrinology, 157, 3253-3265.

Libros y capítulos recientes

Joseph-Bravo,P. Gutierrez-Mariscal,M. Jaimes-Hoy,L. Charli,J.L. 2019. Thyroid Axis and Energy Balance: Focus on Animals and Implications for Humankind en: Patel,V.B. Handbook of Famine, Starvation, and Nutrient Deprivation: From Biology to Policy. Cham, Suiza. Springer International Publishing. pags. 1099-1126


Otras Publicaciones

Guerra-Crespo,M. Charli,J.L. Perez-Martinez,L. 2005. Los arreglos de DNA: explorando la expresion genetica del cerebro Ciencia, Revista de la Academia Mexicana de Ciencia, 56, 67-76.

Charli,J.L. Ponce,G. Torres,H. Garat,B. Barquin,N. Bravo,P.J. 1983. [Cellular biochemistry of hypophysiotropic peptides. II. Liberation, action and inactivation].Boletin de estudios medicos y biologicos, 32, 243-252.

Joseph-Bravo,P. Theleen,M. de Gortari,P. Shapiro,E. Redondo,J.L. Briones,M. Merchant,H. Charli,J.L. 1983. [Biochemistry of hypophysiotropic peptides. I. Biosynthesis and its regulation].Boletin de estudios medicos y biologicos, 32, 233-241.

* Indica publicación con otra institución de adscripción



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