IBT-UNAM : Dra. Cinthia Ernestina Nuñez López
Dra. Cinthia Ernestina Nuñez López
Grupo de la Dra. Elda Guadalupe Espin
email: cinthia @ibt.unam.mx
Teléfonos
Oficina +52 (777) 329-1777 ext 38273. red UNAM 38273 Laboratorio +52 (777) 329-1629 red UNAM 27629
- Licenciatura: Química Farmacobiologa, Fac. de Ciencias Químicas, Universidad de Guadalajara (1987)
Estudiantes IBQ. Carlos Leonel Ahumada
Victor Vicente Barrios
Iliana Chantal Martinez
M.C. Marcela Martinez
Miriam Citlalli Gonzaga
Publicaciones recientes
Martinez-Ortiz,I.C. Ahumada-Manuel,C.L. Hsueh,B.Y. Guzman,J. Moreno,S. Cocotl-Yanez,M. Waters,C.M. Zamorano-Sanchez,D. Espin,G. Nunez,C.
2020. Cyclic di-GMP-Mediated Regulation of Extracellular Mannuronan C-5 Epimerases Is Essential for Cyst Formation in Azotobacter vinelandii Journal of Bacteriology, 202, e00135-20.
Ahumada-Manuel,C.L. Martinez-Ortiz,I.C. Hsueh,B.Y. Guzman,J. Waters,C.M. Zamorano-Sanchez,D. Espin,G. Nunez,C.
2020. Increased c-di-GMP Levels Lead to the Production of Alginates of High Molecular Mass in Azotobacter vinelandii Journal of Bacteriology, 202, e00134-20.
Garcia,A. Castillo,T. Ramos,D. Ahumada-Manuel,C.L. Nunez,C. Galindo,E. Buchs,J. Pena,C.
2020. Molecular weight and viscosifying power of alginates produced by mutant strains of Azotobacter vinelandii under microaerophilic conditions Biotechnology Reports, 26, e00436.
Lopez-Pliego,L. Mena-Munoz,G. Teran-Melo,J.L. Fuentes,L.E. Nunez,C.E. Castaneda,M.
2020. Study of the sRNA RsmY involved in the genetic regulation of the synthesis of alginate and alkyl resorcinols in Azotobacter vinelandii Archives of Microbiology, 202, 579-589.
Martinez-Valenzuela,M. Guzman,J. Moreno,S. Ahumada-Manuel,C.L. Espin,G. Nunez,C.
2018. Expression of the sRNAs CrcZ and CrcY modulate the strength of carbon catabolite repression under diazotrophic or non-diazotrophic growing conditions in Azotobacter vinelandii PLoS ONE, 13, e0208975.
Moreno,S. Ertesvag,H. Valla,S. Nunez,C. Espin,G. Cocotl-Yanez,M.
2018. RpoS controls the expression and the transport of the AlgE1-7 epimerases in Azotobacter vinelandii Fems Microbiology Letters, 365, fny210.
Lopez-Pliego,L. Garcia-Ramirez,L. Cruz-Gomez,E.A. Dominguez-Ojeda,P. Lopez-Pastrana,A. Fuentes-Ramirez,L.E. Nunez,C. Castaneda,M.
2018. Transcriptional Study of the RsmZ-sRNAs and Their Relationship to the Biosynthesis of Alginate and Alkylresorcinols in Azotobacter vinelandii Molecular Biotechnology, 60, 670-680.
Diaz-Perez,A.L. Nunez,C. Meza-Carmen,V. Campos-Garcia,J.
2018. The expression of the genes involved in leucine catabolism of Pseudomonas aeruginosa is controlled by the transcriptional regulator LiuR and by the CbrAB/Crc system Research in Microbiology, 169, 324-334.
Chowdhury-Paul,S. Pando-Robles,V. Jimenez-Jacinto,V. Segura,D. Espin,G. Nunez,C.
2018. Proteomic analysis revealed proteins induced upon Azotobacter vinelandii encystment Journal of Proteomics, 181, 47-59.
Quiroz-Rocha,E. Bonilla-Badia,F. Garcia-Aguilar,V. Lopez-Pliego,L. Serrano-Roman,J. Cocotl-Yanez,M. Guzman,J. Ahumada-Manuel,C.L. Muriel-Millan,L.F. Castaneda,M. Espin,G. Nunez,C.
2017. Two-component system CbrA/CbrB controls alginate production in Azotobacter vinelandii Microbiology, 163, 1105-1115.
Quiroz-Rocha,E. Moreno,R. Hernandez-Ortiz,A. Fragoso-Jimenez,J.C. Muriel-Millan,L.F. Guzman,J. Espin,G. Rojo,F. Nunez,C.
2017. Glucose uptake in Azotobacter vinelandii occurs through a GluP transporter that is under the control of the CbrA/CbrB and Hfq-Crc systems Scientific Reports, 7, 858.
Ahumada-Manuel,C.L. Guzman,J. Pena,C. Quiroz-Rocha,E. Espin,G. Nunez,C.
2017. The signaling protein MucG negatively affects the production and the molecular mass of alginate in Azotobacter vinelandii Applied Microbiology and Biotechnology, 101, 1521-1534.
Nunez,C. Pena,C. Kloeckner,W. Hernandez-Eligio,A. Bogachev,A.V. Moreno,S. Guzman,J. Buchs,J. Espin,G.
2013. Alginate synthesis in Azotobacter vinelandii is increased by reducing the intracellular production of ubiquinone Applied Microbiology and Biotechnology, 97, 2503-2512.
Gaytan,I. Pena,C. Nunez,C. Cordova,M.S. Espin,G. Galindo,E.
2012. Azotobacter vinelandii lacking the Na +-NQR activity: a potential source for producing alginates with improved properties and at high yield World Journal Of Microbiology & Biotechnology, 28, 2731-2740.
Hernandez-Eligio,A. Moreno,S. Castellanos,M. Castaneda,M. Nunez,C. Muriel-Millan,L.F. Espin,G.
2012. RsmA post-transcriptionally controls PhbR expression and polyhydroxybutyrate biosynthesis in Azotobacter vinelandii Microbiology, 158, 1953-1963.
Manzo,J. Cocotl-Yanez,M. Tzontecomani,T. Martinez,V.M. Bustillos,R. Velasquez,C. Goiz,Y. Solis,Y. Lopez,L. Fuentes,L.E. Nunez,C. Segura,D. Espin,G. Castaneda,M.
2011. Post-Transcriptional Regulation of the Alginate Biosynthetic Gene algD by the Gac/Rsm System in Azotobacter vinelandii Journal of Molecular Microbiology and Biotechnology, 21, 147-159.
Cocotl-Yanez,M. Sampieri,A. Moreno,S. Nunez,C. Castaneda,M. Segura,D. Espin,G.
2011. Roles of RpoS and PsrA in cyst formation and alkylresorcinol synthesis in Azotobacter vinelandii Microbiology, 157, 1685-1693.
Leang,C. Krushkal,J. Ueki,T. Puljic,M. Sun,J. Juarez,K. Nunez,C. Reguera,G. Didonato,R. Postier,B. Adkins,R.M. Lovley,D.R.
2009. Genome-wide analysis of the RpoN regulon in Geobacter sulfurreducens BMC Genomics, 10, 331.
Nunez,C. Bogachev,A.V. Guzman,G. Tello,I. Guzman,J. Espin,G.
2009. The Na+-translocating NADH : ubiquinone oxidoreductase of Azotobacter vinelandii negatively regulates alginate synthesis Microbiology, 155, 249-256.
Fadeeva,M.S. Nunez,C. Bertsova,Y.V. Espin,G. Bogachev,A.V.
2008. Catalytic properties of Na+-translocating NADH : quinone oxidoreductases from Vibrio harveyi, Klebsiella pneumoniae, and Azotobacter vinelandii Fems Microbiology Letters, 279, 116-123.
Galindo,E. Pena,C. Nunez,C. Segura,D. Espin,G.
2007. Molecular and bioengineering strategies to improve alginate and polydydroxyalkanoate production by Azotobacter vinelandii Microbial Cell Factories, 6, 7.
Yan,B. Nunez,C. Ueki,T. Esteve-Nunez,A. Puljic,M. Adkins,R.M. Methe,B.A. Lovley,D.R. Krushkal,J.
2006. Computational prediction of RpoS and RpoD regulatory sites in Geobacter sulfurreducens using sequence and gene expression information Gene, 384, 73-95.
Nunez,C. Esteve-Nunez,A. Giometti,C. Tollaksen,S. Khare,T. Lin,W. Lovley,D.R. Methe,B.A.
2006. DNA Microarray and Proteomic Analyses of the RpoS Regulon in Geobacter sulfurreducens Journal of Bacteriology, 188, 2792-2800.
Butler,J.E. Glaven,R.H. Esteve-Nunez,A. Nunez,C. Shelobolina,E.S. Bond,D.R. Lovley,D.R.
2006. Genetic Characterization of a Single Bifunctional Enzyme for Fumarate Reduction and Succinate Oxidation in Geobacter sulfurreducens and Engineering of Fumarate Reduction in Geobacter metallireducens Journal of Bacteriology, 188, 450-455 * .
Gaona,G. Nunez,C. Goldberg,J.B. Linford,A.S. Najera,R. Castaneda,M. Guzman,J. Espin,G. Soberon-Chavez,G.
2004. Characterization of the Azotobacter vinelandii algC gene involved in alginate and lipopolysaccharide production Fems Microbiology Letters, 238, 199-206.
Nunez,C. Adams,L. Childers,S. Lovley,D.R.
2004. The RpoS Sigma Factor in the Dissimilatory Fe(III)-Reducing Bacterium Geobacter sulfurreducens Journal of Bacteriology, 186, 5543-5546.
Butler,J.E. Kaufmann,F. Coppi,M.V. Nunez,C. Lovley,D.R.
2004. MacA, a Diheme c-Type Cytochrome Involved in Fe(III) Reduction by Geobacter sulfurreducens Journal of Bacteriology, 186, 4042-4045 * .
Esteve-Nunez,A. Nunez,C. Lovley,D.R.
2004. Preferential Reduction of Fe(III) over Fumarate by Geobacter sulfurreducens Journal of Bacteriology, 186, 2897-2899.
Jara,N. Nunez,C. Campoy,S. de Henestrosa,A. Lovley,D.R. Barbe,J.
2003. Geobacter sulfurreducens has two autoregulated lexA genes whose products do not bind the recA promoter: Differing responses of lexA and recA to DNA damage Journal of Bacteriology, 185, 2493-2502.
Pena,C. Miranda,L. Segura,D. Nunez,C. Espin,G. Galindo,E.
2002. Alginate production by Azotobacter vinelandii mutants altered in poly-beta-hydroxybutyrate and alginate biosynthesis Journal of Industrial Microbiology & Biotechnology, 29, 209-213.
Castaneda,M. Sanchez,J. Moreno,S. Nunez,C. Espin,G.
2001. The Global Regulators GacA and sigma(S) Form Part of a Cascade That Controls Alginate Production in Azotobacter vinelandii Journal of Bacteriology, 183, 6787-6793.
Gama-Castro,S. Nunez,C. Segura,D. Moreno,S. Guzman,J. Espin,G.
2001. Azotobacter vinelandii Aldehyde Dehydrogenase Regulated by sigma(54): Role in Alcohol Catabolism and Encystment Journal of Bacteriology, 183, 6169-6174.
Nunez,C. Moreno,S. Cardenas,L. Soberon-Chavez,G. Espin,G.
2000. Inactivation of the ampDE operon increases transcription of algD and affects morphology and encystment of Azotobacter vinelandii Journal of Bacteriology, 182, 4829-4835.
Nunez,C. Leon,R. Guzman,J. Espin,G. Soberon-Chavez,G.
2000. Role of Azotobacter vinelandii mucA and mucC gene products in alginate production Journal of Bacteriology, 182, 6550-6556.
Nunez,C. Moreno,S. Soberon-Chavez,G. Espin,G.
1999. The Azotobacter vinelandii response regulator AlgR is essential for cyst formation Journal of Bacteriology, 181, 141-148.
Campos,M. Martinez-Salazar,J.M. Lloret,L. Moreno,S. Nunez,C. Espin,G. Soberon-Chavez,G.
1996. Characterization of the gene coding for GDP-mannose dehydrogenase (algD) from Azotobacter vinelandii Journal of Bacteriology, 178, 1793-1799.
Libros y capítulos recientes Segura,D. Nunez,C. Espin,G. 2020. Azotobacter Cysts en: eLS. Chichester, West Sussex. Editorial John Wiley & Sons.
Segura,D. Nunez,C. Espin,G. 2014. Azotobacter Cysts en: Encyclopedia of Life Science. Chichester, West Sussex. Editorial John Wiley & Sons.
Nuñez-Lopez,C.E. Segura-Gonzalez,D.G. 2014. La contaminación por plásticos: bacterias al rescate en: Rebolledo,F. Un Mundo de Bacterias. UNAM, Campus Morelos. pags. 105-108
Pena,C. Castillo,T. Segura,D. Nunez,C. 2011. Bioprocess design: fermentation strategies for improving the production of alginate and poly-beta-hydroxybutyrate (PHB) by Azotobacter vinelandii en: Carpi,A. Progress in Molecular and Environmental Bioengineering. Intech. pags. 217-242
Krushkal,J. Puljic,M. Bin Yan Barbe,J.F. Mahadevan,R. Postier,B. O'Neil,R.A. Reguera,G. Leang,C. DiDonato,L.N. Nunez,C. Methe,B.A. Adkins,R.M. Lovley,D.R. 2008. Genome Regions Involved in Multiple Regulatory Pathways Identified Using GSEL, A Genome-Wide Database of Regulatory Sequence Elements of Geobacter sulfurreducens en: BioMedical Engineering and Informatics, 2008. BMEI 2008. International Conference on. IEEE. pags. 424-431
Otras Publicaciones Martinez-Valenzuela,M. Nuñez-López,C.E.
2020. ARN pequeños en bacterias: decisiones sobre la selección del menú Biotecnología en Movimiento.Revista de divulgación del Instituto de Biotecnología de la UNAM, 21, 12-17.
Quiroz-Rocha,E. Nunez-Lopez,C.E.
2018. Entendiendo cómo una bacteria del suelo selecciona su alimento para producir biopolímeros Biotecnología en Movimiento.Revista de divulgación del Instituto de Biotecnología de la UNAM, 12, 14-16.
* Indica publicación con otra institución de adscripción
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