IBT-UNAM : Dr. Daniel Genaro Segura Gonzalez
Dr. Daniel Genaro Segura Gonzalez
Grupo de la Dra. Elda Guadalupe Espin
email: daniel @ibt.unam.mx
Teléfonos
Oficina +52 (777) 329-1777 ext 38273. red UNAM 38273
- Licenciatura: Biología, Fac. de Ciencias-UNAM (1987)
Estudiantes M.C. Claudia Velazquez
Biol. Fernando Loyola
Claudia Ventura
Ing. Andrea Viridiana Moyao
Lic. Jessica Ruiz
Libertad Alejandra Adaya
Lic. Thalía Barrientos
Publicaciones recientes
Velazquez-Sanchez,C. Espin,G. Pena,C. Segura,D.
2020. The Modification of Regulatory Circuits Involved in the Control of Polyhydroxyalkanoates Metabolism to Improve Their Production Frontiers in Bioengineering and Biotechnology, 8, 386.
Salcedo-Vite,K. Sigala,J.C. Segura,D. Gosset,G. Martinez,A.
2019. Acinetobacter baylyi ADP1 growth performance and lipid accumulation on different carbon sources Applied Microbiology and Biotechnology, 103, 6217-6229.
Chowdhury-Paul,S. Pando-Robles,V. Jimenez-Jacinto,V. Segura,D. Espin,G. Nunez,C.
2018. Proteomic analysis revealed proteins induced upon Azotobacter vinelandii encystment Journal of Proteomics, 181, 47-59.
Castillo,T. Lopez,I. Flores,C. Segura,D. Garcia,A. Galindo,E. Pena,C.
2018. Oxygen uptake rate in alginate producer (algU+) and non-producer (algU-) strains of Azotobacter vinelandii under nitrogen-fixation conditions Journal of Applied Microbiology, 125, 181-189.
Adaya,L. Millan,M. Pena,C. Jendrossek,D. Espin,G. Tinoco-Valencia,R. Guzman,J. Pfeiffer,D. Segura,D.
2018. Inactivation of an intracellular poly-3-hydroxybutyrate depolymerase of Azotobacter vinelandii allows to obtain a polymer of uniform high molecular mass Applied Microbiology and Biotechnology, 102, 2693-2707.
Garcia,A. Ferrer,P. Albiol,J. Castillo,T. Segura,D. Pena,C.
2018. Metabolic flux analysis and the NAD(P)H/NAD(P)(+) ratios in chemostat cultures of Azotobacter vinelandii Microbial Cell Factories, 17, 10.
Millan,M. Salazar,M. Segura,D. Castillo,T. Diaz-Barrera,A. Pena,C.
2017. Molecular mass of Poly-3-hydroxybutyrate (P3HB) produced by Azotobacter vinelandii is influenced by the polymer content in the inoculum Journal of Biotechnology, 259, 50-55.
Romero-Ramirez,Y. Hernandez-Flores,G. Rodriguez-Barrera,M.A. Segura-Gonzalez,D. Martinez-Galero,N.X. Toribio-Jimenez,J. Castellanos Escamilla,M. Hernandez-Eligio,J.A.
2017. Evaluation of polyhydroxyalkanoates producing bacteria isolated from soils with wastes of Cocos nucifera Revista Internacional de Contaminacion Ambiental, 33, 115-123.
Castillo,T. Flores,C. Segura,D. Espin,G. Sanguino,J. Cabrera,E. Barreto,J. Diaz-Barrera,A. Pena,C.
2017. Production of polyhydroxybutyrate (PHB) of high and ultra-high molecular weight by Azotobacter vinelandii in batch and fed-batch cultures Journal of Chemical Technology & Biotechnology, 92, 1809-1816.
Millan,M. Segura,D. Galindo,E. Pena,C.
2016. Molecular mass of poly-3-hydroxybutyrate (P3HB) produced by Azotobacter vinelandii is determined by the ratio of synthesis and degradation under fixed dissolved oxygen tension Process Biochemistry, 51, 950-958.
Romero-Rodriguez,A. Rocha,D. Ruiz-Villafan,B. Tierrafria,V. Rodriguez-Sanoja,R. Segura-Gonzalez,D. Sanchez,S.
2016. Transcriptomic analysis of a classical model of carbon catabolite regulation in Streptomyces coelicolor BMC Microbiology, 16, 77.
Jimenez,L. Castillo,T. Flores,C. Segura,D. Galindo,E. Pena,C.
2016. Analysis of respiratory activity and carbon usage of a mutant of Azotobacter vinelandii impaired in poly-beta-hydroxybutyrate synthesis Journal of Industrial Microbiology & Biotechnology, 43, 1167-1174.
Romero,Y. Guzman,J. Moreno,S. Cocotl-Yanez,M. Vences-Guzman,M.A. Castaneda,M. Espin,G. Segura,D.
2016. The GacS/A-RsmA Signal Transduction Pathway Controls the Synthesis of Alkylresorcinol Lipids that Replace Membrane Phospholipids during Encystment of Azotobacter vinelandii SW136 PLoS ONE, 11, e0153266.
Muriel-Millan,L.F. Moreno,S. Romero,Y. Bedoya-Perez,L.P. Castaneda,M. Segura,D. Espin,G.
2015. The Unphosphorylated EIIANtr Protein Represses the Synthesis of Alkylresorcinols in Azotobacter vinelandii PLoS ONE, 10, e0117184.
Dominguez-Diaz,M. Meneses-Acosta,A. Romo-Uribe,A. Pena,C. Segura,D. Espin,G.
2015. Thermo-mechanical properties, microstructure and biocompatibility in poly-beta-hydroxybutyrates (PHB) produced by OP and OPN strains of Azotobacter vinelandii European Polymer Journal, 63, 101-112.
Toribio-Jimenez,J. Rodriguez-Barrera,M.A. Vladez-Lucena,M. Barrera-Flores,A. Segura,D. Wilson-Corral,V. Flores-Alfaro,E. Romero,Y.
2014. Production of biosurfactants by bacteria isolated from a mine tailing zone in Southern Mexico and their resistance to heavy metals Journal of Bacteriology Research, 6, 23-31.
Pena,C. Castillo,T. Garcia,A. Millan,M. Segura,D.
2014. Biotechnological strategies to improve production of microbial poly-(3-hydroxybutyrate): a review of recent research work Microbial Biotechnology, 7, 278-293.
Catone,M.V. Ruiz,J.A. Castellanos,M. Segura,D. Espin,G. Lopez,N.I.
2014. High Polyhydroxybutyrate Production in Pseudomonas extremaustralis Is Associated with Differential Expression of Horizontally Acquired and Core Genome Polyhydroxyalkanoate Synthase Genes PLoS ONE, 9, e98873.
Garcia,A. Segura,D. Espin,G. Galindo,E. Castillo,T. Pena,C.
2014. High production of poly-beta-hydroxybutyrate (PHB) by an Azotobacter vinelandii mutant altered in PHB regulation using a fed-batch fermentation process Biochemical Engineering Journal, 82, 117-123.
Pena,C. Lopez,S. Garcia,A. Espin,G. Romo-Uribe,A. Segura,D.
2014. Biosynthesis of poly-b-hydroxybutyrate (PHB) with a high molecular mass by a mutant strain of Azotobacter vinelandii (OPN) Annals of Microbiology, 64, 39-47.
Romero,Y. Moreno,S. Guzman,J. Espin,G. Segura,D.
2013. The Sigma Factor RpoS Controls Alkylresorcinol Synthesis Through ArpR, a LysR-Type Regulatory Protein During Encystment of Azotobacter vinelandii Journal of Bacteriology, 195, 1834-1844.
Manzo,J. Cocotl-Yanez,M. Tzontecomani,T. Martinez,V.M. Bustillos,R. Velasquez,C. Goiz,Y. Solis,Y. Lopez,L. Fuentes,L.E. Nunez,C. Segura,D. Espin,G. Castaneda,M.
2011. Post-Transcriptional Regulation of the Alginate Biosynthetic Gene algD by the Gac/Rsm System in Azotobacter vinelandii Journal of Molecular Microbiology and Biotechnology, 21, 147-159.
Cocotl-Yanez,M. Sampieri,A. Moreno,S. Nunez,C. Castaneda,M. Segura,D. Espin,G.
2011. Roles of RpoS and PsrA in cyst formation and alkylresorcinol synthesis in Azotobacter vinelandii Microbiology, 157, 1685-1693.
Mejia,M.A. Segura,D. Espin,G. Galindo,E. Pena,C.
2010. Two-stage fermentation process for alginate production by Azotobacter vinelandii mutant altered in poly-beta-hydroxybutyrate (PHB) synthesis Journal of Applied Microbiology, 108, 55-61.
Setubal,J.C. Dos Santos P. Goldman,B.S. Ertesvag,H. Espin,G. Rubio,L.M. Valla,S. Almeida,N.F. Balasubramanian,D. Cromes,L. Curatti,L. Du,Z. Godsy,E. Goodner,B. Hellner-Burris,K. Hernandez,J.A. Houmiel,K. Imperial,J. Kennedy,C. Larson,T.J. Latreille,P. Ligon,L.S. Lu,J. Maerk,M. Miller,N.M. Norton,S. O'Carroll,I.P. Paulsen,I. Raulfs,E.C. Roemer,R. Rosser,J. Segura,D. Slater,S. Stricklin,S.L. Studholme,D.J. Sun,J. Viana,C.J. Wallin,E. Wang,B. Wheeler,C. Zhu,H. Dean,D.R. Dixon,R. Wood,D.
2009. The genome sequence of Azotobacter vinelandii, an obligate aerobe specialized to support diverse anaerobic metabolic processes Journal of Bacteriology, 191, 4534-4545.
Segura,D. Vite,O. Romero,Y. Moreno,S. Castaneda,M. Espin,G.
2009. Isolation and Characterization of Azotobacter vinelandii Mutants Impaired in Alkylresorcinol Synthesis: Alkylresorcinols are not Essential for Cysts Desiccation Resistance Journal of Bacteriology, 191, 3142-3148.
Segura,D. Mahadevan,R. Juarez,K. Lovley,D.R.
2008. Computational and experimental analysis of redundancy in the central metabolism of Geobacter sulfurreducens PLoS Computational Biology, 4, e36 (erratum en 4(3). doi: 10.1371/annotation/67743d4d-2993-4d0c-951b-3f11ce65a8b4.).
Noguez,R. Segura,D. Moreno,S. Hernandez,A. Juarez,K. Espin,G.
2008. Enzyme I, NPr and IIA(Ntr) Are Involved in Regulation of the Poly-beta-Hydroxybutyrate Biosynthetic Genes in Azotobacter vinelandii Journal of Molecular Microbiology and Biotechnology, 15, 244-254.
Galindo,E. Pena,C. Nunez,C. Segura,D. Espin,G.
2007. Molecular and bioengineering strategies to improve alginate and polydydroxyalkanoate production by Azotobacter vinelandii Microbial Cell Factories, 6, 7.
Segura,D. Espin,G.
2004. Inactivation of pycA, encoding pyruvate carboxylase activity, increases poly-beta-hydroxybutyrate accumulation in Azotobacter vinelandii on solid medium Applied Microbiology and Biotechnology, 65, 414-418.
Segura,D. Guzman,J. Espin,G.
2003. Azotobacter vinelandii mutants that overproduce poly-beta-hydroxybutyrate or alginate Applied Microbiology and Biotechnology, 63, 159-163.
Segura,D. Cruz,T. Espin,G.
2003. Encystment and alkylresorcinol production by Azotobacter vinelandii strains impaired in poly-beta-hydroxybutyrate synthesis Archives of Microbiology, 179, 437-443.
Trujillo-Roldan,M.A. Moreno,S. Segura,D. Galindo,E. Espin,G.
2003. Alginate production by an Azotobacter vinelandii mutant unable to produce alginate lyase Applied Microbiology and Biotechnology, 60, 733-737.
Pena,C. Miranda,L. Segura,D. Nunez,C. Espin,G. Galindo,E.
2002. Alginate production by Azotobacter vinelandii mutants altered in poly-beta-hydroxybutyrate and alginate biosynthesis Journal of Industrial Microbiology & Biotechnology, 29, 209-213.
Peralta-Gil,M. Segura,D. Guzman,J. Servin-Gonzalez,L. Espin,G.
2002. Expression of the Azotobacter vinelandii Poly-beta-Hydroxybutyrate Biosynthetic phbBAC Operon Is Driven by Two Overlapping Promoters and Is Dependent on the Transcriptional Activator PhbR Journal of Bacteriology, 184, 5672-5677.
Gama-Castro,S. Nunez,C. Segura,D. Moreno,S. Guzman,J. Espin,G.
2001. Azotobacter vinelandii Aldehyde Dehydrogenase Regulated by sigma(54): Role in Alcohol Catabolism and Encystment Journal of Bacteriology, 183, 6169-6174.
Segura,D. Vargas,E. Espin,G.
2000. Beta-ketothiolase genes in Azotobacter vinelandii Gene, 260, 113-120.
Segura,D. Espin,G.
1998. Mutational inactivation of a gene homologous to Escherichia coli ptsP affects poly-beta-hydroxybutyrate accumulation and nitrogen fixation in Azotobacter vinelandii Journal of Bacteriology, 180, 4790-4798.
Libros y capítulos recientes Segura,D. Nunez,C. Espin,G. 2020. Azotobacter Cysts en: eLS. Chichester, West Sussex. Editorial John Wiley & Sons.
Segura,D. Nunez,C. Espin,G. 2014. Azotobacter Cysts en: Encyclopedia of Life Science. Chichester, West Sussex. Editorial John Wiley & Sons.
Nuñez-Lopez,C.E. Segura-Gonzalez,D.G. 2014. La contaminación por plásticos: bacterias al rescate en: Rebolledo,F. Un Mundo de Bacterias. UNAM, Campus Morelos. pags. 105-108
Romero,Y. Pena,C. Rojas,A. Tortajada,M. Espin,G. Segura,D. 2014. Una mutante de Azotobacter vinelandii productora de PHB que carece de los en: Mendez,B. Bioplasticos. Lisboa, Portugal. Editorial CYTED. pags. 23-31
Pena,C. Castillo,T. Segura,D. Nunez,C. 2011. Bioprocess design: fermentation strategies for improving the production of alginate and poly-beta-hydroxybutyrate (PHB) by Azotobacter vinelandii en: Carpi,A. Progress in Molecular and Environmental Bioengineering. Intech. pags. 217-242
Segura,D. Noguez,R. Espin,G. 2008. Contaminación ambiental y bacterias productoras de plásticos biodegradables en: *agustin Una ventana al quehacer científico. Instituto de Biotecnología de la UNAM 25 aniversario, cap 31. Mexico, D.F.. UNAM. pags. 361-372
Otras Publicaciones Pena-Malacara,C. Segura-Gonzalez,D.
2011. Geles y plásticos hechos bajo diseño por fermentación bacteriana Hypatia, 35, 4-5.
Espin,G. Moreno,S. Segura,D. Moreno,Y.
2006. Alkylresorcinols synthesis and its role in the production of cysts in Azotobacter Revista Latinoamericana de Microbiologia, 48, 129-130.
Santana,C. Segura,D. Sanchez,S.
1994. [Synthesis, function, and evolutionary origin of secondary metabolites produced by micro-organisms] Revista Latinoamericana de Microbiologia, 36, 139-158.
Investigador