Instituto de Biotecnologia UNAM

IBT-UNAM : Dr. Alberto Darszon Israel

Dr.

Dr. Alberto Darszon Israel


Líder Académico »» Grupo

Investigador

Tutor de Maestría y Doctorado

Nivel Inv. de Excelencia del SNI

Departamento de Genética del Desarrollo y Fisiología Molecular

Líneas de investigación

email: darszon@ibt.unam.mx


- Licenciatura: Química, Universidad Iberoamericana, Fac. de Química (1972)
- Doctorado: en Ciencias, CINVESTAV-IPN, Dpto. de Bioquímica, (1977)
- Estancia de Investigación: Universidad de California, en San Diego, CA, E.U.A. (1978)


Premio Scopus México 2008 Editorial Elsevier (2008)
Premio Imaging Solutions of the Year, en el área de Microscopía Revista Industrial Advanced Imaging (2008)
Wellcome Trust Collaborative Research Initiative Grant 2004-2007 (2004)
Fogarty International Research Collaboration Award (2003-2005) NIH (2003)
Premio Universidad Nacional en el área de investigación en Ciencias Naturales UNAM (2000)
Howard Hughes Medical Institute International Research Scholar 1991-1996 (1991)
Premio Miguel Alemán en el Area Salud (1989)


Estudiantes

M.C. Gabriela Carrasquel

Verónica Loyo

M.C. Hector Vicente Ramirez

Publicaciones recientes

Zhao,R. Kennedy,K. de Blas,G.A. Orta,G. Pavarotti,M.A. Arias,R.J. De la Vega-Beltran JL Li,Q. Dai,H. Perozo,E. Mayorga,L.S. Darszon,A. Goldstein,S.A.N. 2018. Role of human Hv1 channels in sperm capacitation and white blood cell respiratory burst established by a designed peptide inhibitor Proceedings of the National Academy of Sciences of the United States of America, 115, E11847-E11856.

Priego-Espinosa,D.A. Darszon,A. Guerrero,A. Gonzalez-Cota,A.L. Nishigaki,T. Martinez-Mekler,G. Carneiro,J. 2018. Modular mathematical analysis of the control of flagellar Ca2+-spike trains produced by CatSper and Cav channels in sea urchin sperm bioRxiv, preprint posted October 18, 2018, .

Romarowski,A. Velasco Felix,A.G. Torres-Rodriguez P. Gervasi,M.G. Xu,X. Luque,G.M. Contreras-Jimenez,G. Sanchez-Cardenas,C. Ramirez-Gomez,H.V. Krapf,D. Visconti,P.E. Krapf,D. Guerrero,A. Darszon,A. Buffone,M.G. 2018. Super-resolution imaging of live sperm reveals dynamic changes of the actin cytoskeleton during acrosomal exocytosis Journal of Cell Science, 131, jcs218958.

Orta,G. Vega-Beltran,J.L. Hidalgo,D. Santi,C.M. Visconti,P. Darszon,A. 2018. CatSper channels are regulated by protein kinase A Journal of Biological Chemistry, 293, 16830.

Brukman,N.G. Nunez,S.Y. Puga Molina,L.D.C. Buffone,M.G. Darszon,A. Cuasnicu,P.S. Da Ros,V. 2018. Tyrosine phosphorylation signaling regulates Ca(2+) entry by affecting intracellular pH during human sperm capacitation Journal of Cellular Physiology, Sep 10 [Epub ahead of print], .

Sanchez-Cardenas,C. Montoya,F. Navarrete,F.A. Hernandez-Cruz,A. Corkidi,G. Visconti,P.E. Darszon,A. 2018. Intracellular Ca2+ threshold reversibly switches flagellar beat off and on Biology of Reproduction, Jun 8 [Epub ahead of print], .

Hernandez-Herrera,P. Montoya,F. Rendon-Mancha,J.M. Darszon,A. Corkidi,G. 2018. 3D+t Human Sperm Flagellum Tracing in low SNR Fluorescence Images IEEE Transactions on Medical Imaging, 37, 2236-2247.

Puga Molina,L.C. Pinto,N.A. Torres,N.I. Gonzalez-Cota,A.L. Luque,G.M. Balestrini,P.A. Romarowski,A. Krapf,D. Santi,C.M. Trevino,C.L. Darszon,A. Buffone,M.G. 2018. CFTR/ENaC dependent regulation of membrane potential during human sperm capacitation is initiated by bicarbonate uptake through NBC Journal of Biological Chemistry, 293, 9924-9936.

Stival,C. Ritagliati,C. Xu,X. Gervasi,M.G. Luque,G.M. Baro,G.C. Vega-Beltran,J.L. Torres,N.I. Darszon,A. Krapf,D. Buffone,M.G. Visconti,P. Krapf,D. 2018. Disruption of protein kinase A localization induces acrosomal exocytosis in capacitated mouse sperm Journal of Biological Chemistry, 293, 9435-9447.

Mata-Martinez,E. Darszon,A. Trevino,C.L. 2018. pH-dependent Ca(+2) oscillations prevent untimely acrosome reaction in human sperm Biochemical and Biophysical Research Communications, 497, 146-152.

Chavez,J.C. De la Vega-Beltran JL Jose,O. Torres,P. Nishigaki,T. Trevino,C.L. Darszon,A. 2018. Acrosomal alkalization triggers Ca2+ release and acrosome reaction in mammalian spermatozoa Journal of Cellular Physiology, 233, 4735-4747.

Ramirez-Gomez,H.V. Jimenez-Sabinina,V. Tuval,I. Velazquez-Perez,M. Beltran,C. Carneiro,J. Wood,C. Darszon,A. Guerrero,A. 2017. Sperm chemotaxis is driven by the slope of the chemoattractant concentration field bioRxiv, preprint Posted June 10, 2017, .

Corkidi,G. Montoya,F. Hernandez-Herrera,P. Rios-Herrera,W.A. Muller,M.F. Trevino,C.L. Darszon,A. 2017. Are there intracellular Ca2+ oscillations correlated with flagellar beating in human sperm? A three vs. two-dimensional analysis Molecular Human Reproduction, 23, 583-593.

Espinal-Enriquez,J. Priego-Espinosa,D.A. Darszon,A. Beltran,C. Martinez-Mekler,G. 2017. Network model predicts that CatSper is the main Ca2+ channel in the regulation of sea urchin sperm motility Scientific Reports, 7, 4236.

Puga Molina,L.C. Pinto,N.A. Torres-Rodriguez P. Romarowski,A. Vicens-Sanchez A. Visconti,P.E. Darszon,A. Trevino,C.L. Buffone,M.G. 2017. Essential Role of CFTR in PKA-Dependent Phosphorylation, Alkalinization and Hyperpolarization During Human Sperm Capacitation Journal of Cellular Physiology, 232, 1404-1414.

Navarrete,F.A. Alvau,A. Lee,H.C. Levin,L.R. Buck,J. Leon,P.M. Santi,C.M. Krapf,D. Mager,J. Fissore,R.A. Salicioni,A.M. Darszon,A. Visconti,P.E. 2016. Transient exposure to calcium ionophore enables in vitro fertilization in sterile mouse models Scientific Reports, 6, 33589.

Alvau,A. Battistone,M.A. Gervasi,M.G. Navarrete,F.A. Xu,X. Sanchez-Cardenas,C. de la Vega-Beltran,J.L. Da- Ros,V. Greer,P. Darszon,A. Krapf,D. Salicioni,A.M. Cuasnicu,P. Visconti,P.E. 2016. The tyrosine kinase FER is responsible for the capacitation-associated increase in tyrosine phosphorylation in murine sperm Development, 143, 2325-2333.

Romarowski,A. Sanchez-Cardenas,C. Ramirez-Gomez,H.V. Puga Molina,L.D. Trevino,C.L. Hernandez,C.A. Darszon,A. Buffone,M.G. 2016. A Specific Transitory Increase in Intracellular Calcium Induced by Progesterone Promotes Acrosomal Exocytosis in Mouse Sperm Biology of Reproduction, 94, 63.

Garcia-Rincon,J. Darszon,A. Beltran,C. 2016. Speract, a sea urchin egg peptide that regulates sperm motility, also stimulates sperm mitochondrial metabolism Biochimica et Biophysica Acta (BBA), 1857, 415-426.

Lopez-Gonzalez,I. Trevino,C.L. Darszon,A. 2016. Regulation of Spermatogenic Cell T-Type Ca Currents by Zn : Implications in Male Reproductive Physiology Journal of Cellular Physiology, 231, 659-667.

Ernesto,J.I. Weigel-Munoz M. Battistone,M.A. Vasen,G. Martinez-Lopez,P. Orta,G. Figueiras-Fierro,D. de la Vega-Beltran,J.L. Moreno,I.A. Guidobaldi,H.A. Giojalas,L. Darszon,A. Cohen,D.J. Cuasnicu,P.S. 2015. CRISP1 as a novel CatSper regulator that modulates sperm motility and orientation during fertilization Journal of Cell Biology, 210, 1213-1224.

Sanchez-Carranza,O. Torres-Rodriguez,P. Darszon,A. Trevino,C.L. Lopez-Gonzalez,I. 2015. Pharmacology of hSlo3 channels and their contribution in the capacitation-associated hyperpolarization of human sperm Biochemical and Biophysical Research Communications, 466, 554-559.

Gonzalez-Cota,A.L. Silva,P.A. Carneiro,J. Darszon,A. 2015. Single cell imaging reveals that the motility regulator speract induces a flagellar alkalinization that precedes and is independent of Ca(2+) influx in sea urchin spermatozoa FEBS Letters, 589, 2146-2154.

Escoffier,J. Navarrete,F. Haddad,D. Santi,C.M. Darszon,A. Visconti,P.E. 2015. Flow Cytometry Analysis Reveals That Only a Subpopulation of Mouse Sperm Undergoes Hyperpolarization During Capacitation Biology of Reproduction, 92, 121.

Navarrete,F.A. Garcia-Vazquez,F.A. Alvau,A. Escoffier,J. Krapf,D. Sanchez-Cardenas,C. Salicioni,A.M. Darszon,A. Visconti,P.E. 2015. Biphasic Role of Calcium in Mouse Sperm Capacitation Signaling Pathways Journal of Cellular Physiology, 230, 1758-1769.

Chavez,J.C. Ferreira,G.J. Butler,A. Trevino,C.L. Darszon,A. Salkoff,L. Santi,C.M. 2014. SLO3 K+ Channels Control Calcium Entry through CATSPER Channels in Sperm Journal of Biological Chemistry, 289, 32266-32275.

Espinal-Enriquez,J. Darszon,A. Guerrero,A. Martinez-Mekler,G. 2014. In Silico Determination of the Effect of Multi-Target Drugs on Calcium Dynamics Signaling Network Underlying Sea Urchin Spermatozoa Motility PLoS ONE, 9, e104451.

Sanchez-Cardenas,C. Servin-Vences,M.R. Jose,O. Trevino,C.L. Hernandez-Cruz,A. Darszon,A. 2014. Acrosome Reaction and Ca2+ Imaging in Single Human Spermatozoa: New Regulatory Roles of [Ca2+]i Biology of Reproduction, 91, 67.

Beltran,C. Rodriguez-Miranda,E. Granados-Gonzalez,G. de De la Torre LG Nishigaki,T. Darszon,A. 2014. Zn induces hyperpolarization by activation of a K channel and increases intracellular Ca and pH in sea urchin spermatozoa Developmental Biology, 394, 15-23.

Vacquier,V.D. Loza-Huerta,A. Garcia-Rincon,J. Darszon,A. Beltran,C. 2014. Soluble adenylyl cyclase of sea urchin spermatozoa Biochimica et Biophysica Acta (BBA), 1842, 2621-2628.

Nishigaki,T. Jose,O. Gonzalez-Cota,A.L. Romero,F. Trevino,C.L. Darszon,A. 2014. Intracellular pH in Sperm Physiology Biochemical and Biophysical Research Communications, 450, 1149-1158.

Lopez-Gonzalez,I. Torres-Rodriguez,P. Sanchez-Carranza,O. Solis-Lopez,A. Santi,C.M. Darszon,A. Trevino,C.L. 2014. Membrane Hyperpolarization during Human Sperm Capacitation Molecular Human Reproduction, 20, 619-629.

Darszon,A. Hernandez-Cruz,A. 2014. T-type Ca channels in spermatogenic cells and sperm Pflugers Archiv European Journal of Physiology, 466, 819-831.

Libros y capítulos recientes

Ehrlich,H. Montoya,F. Hernandez,P. Darszon,A. Corkidi,G. 2017. Análisis de Métricas Sobre el Flagelo de Espermatozoides de Humano en 3D para su Clasificación entre Activados e Hiperactivados en: Memorias del XL Congreso Nacional de Ingenieria Biomedica CNIB 2017. pags. 182-185

Hernandez-Herrera,P. Montoya,F. Rendon,J.M. Darszon,A. Corkidi,G. 2017. Sperm Flagellum Center-Line Tracing in Fluorescence 3D+t Low SNR Stacks Using an Iterative Minimal Path Method en: Cheriet,F. Image Analysis and Recognition: 14th International Conference, ICIAR 2017, Montreal, QC, Canada, July 5-7, 2017, Proceedings. Cham. Springer International Publishing. pags. 437-445

Beltran,C. Trevino,C.L. Mata-Martinez,E. Chavez,J.C. Sanchez-Cardenas,C. Baker,M. Darszon,A. 2016. Role of Ion Channels in the Sperm Acrosome Reaction en: Buffone,M.G. Sperm Acrosome Biogenesis and Function During Fertilization. Springer International Publishing Switzerland. pags. 35-69

Wood,C.D. Guerrero,A. Priego-Espinosa,D.A. Martinez-Mekler,G. Carneiro,J. Darszon,A. 2015. Sea Urchin Sperm Chemotaxis en: Cosson,J.J. Flagellar Mechanics and Sperm Guidance. pags. 135-182

Silva-Villalobos,F. Pimentel,J.A. Darszon,A. Corkidi,G. 2014. Imaging of the 3D dynamics of flagellar beating in human sperm en: Engineering in Medicine and Biology Society (EMBC), 2014 36th Annual International Conference of the IEEE. pags. 190-193

Trevino,C.L. Orta,G. Figueiras-Fierro,D. De la Vega-Beltran JL Ferreira,G. Balderas,E. Jose,O. Darszon,A. 2014. Cl- channels and transporters in sperm physiology en: Iwano,M. Sexual Reproduction in Animals and Plants. Tokyo. Springer-Japan. pags. 59-84

* Indica publicación con otra institución de adscripción



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