. Instituto de Biotecnologia UNAM

IBT-UNAM : Dr. Juan Enrique Morett Sanchez

Dr. Juan Enrique Morett Sanchez

Líder Académico »» Grupo
Investigador
Tutor de Maestría y Doctorado
Nivel III del SNI
Departamento de Ingeniería Celular y Biocatálisis

Líneas de investigación
-Página personal-

email: emorett @ibt.unam.mx
Teléfonos
Oficina +52 (777) 329-1665
desde la CDMX 562-27665
red UNAM 27665
+52 (777) 311-4900 ext 218

Laboratorio +52 (777) 329-1605
desde la CDMX 562-27605
red UNAM 27605
+52 (777) 311-4900 ext 218

- Licenciatura: Investigacion Biomedica Basica, UNAM (1984)
- Maestría: en Investigacion Biomedica Basica, UNAM (1986)
- Doctorado: en Bioquímica, Universidad de Sussex, Laboratorio de Fijacion de Nitrogeno, Institute of Plant Science Research, Agriculture and Food Research Council, Brighton, Gran Bretana (1990)
- Mencion honorífica en examen de Licenciatura (1985)
- Estancia de Investigación: Mikrobiologisches Institut, Eidgenossische Technische Hochschule, ETH, zurich, Suiza (I-90 a III-91)
- Estancia de Investigación: European Molecular Biology Laboratory, Biocomputing Unit. In Peer Bork's Group. Supported by the Alexander von Humboldt Stiftung (1998-1999)

Estudiantes

M.C. Israel Aguilar

Publicaciones recientes

Jasso-Chavez,R. Lira-Silva,E. Gonzalez-Sanchez,K. Larios-Serrato,V. Mendoza-Monzoy,D.L. Perez-Villatoro,F. Morett,E. Vega-Segura,A. Torres-Marquez,M.E. Zepeda-Rodriguez,A. Moreno-Sanchez,R. 2019. Marine Archaeon Methanosarcina acetivorans Enhances Polyphosphate Metabolism Under Persistent Cadmium Stress Frontiers in Microbiology, 10, 2432.

Romero-Hidalgo,S. Ochoa-Leyva,A. Garciarrubio,A. Acuna-Alonzo,V. Antunez-Arguelles,E. Balcazar-Quintero,M. Barquera-Lozano,R. Carnevale,A. Cornejo-Granados,F. Fernandez-Lopez,J.C. Garcia-Herrera,R. Garcia-Ortiz,H. Granados-Silvestre,A. Granados,J. Guerrero-Romero,F. Hernandez-Lemus,E. Leon-Mimila,P. Macin-Perez,G. Martinez-Hernandez,A. Menjivar,M. Morett,E. Orozco,L. Ortiz-Lopez,G. Perez-Villatoro,F. Rivera-Morales,J. Riveros-McKay,F. Villalobos-Comparan,M. Villamil-Ramirez,H. Villarreal-Molina,T. Canizales-Quinteros,S. Soberon,X. 2017. Demographic history and biologically relevant genetic variation of Native Mexicans inferred from whole-genome sequencing Nature Communications, 8, 1005.

Lara,P. Morett,E. Juarez,K. 2017. Acetate biostimulation as an effective treatment for cleaning up alkaline soil highly contaminated with Cr(VI) Environmental Science and Pollution Research, 24, 25513-25521.

Hernandez-Eligio,A. Andrade,A. Soto,L. Morett,E. Juarez,K. 2017. The unphosphorylated form of the PilR two-component system regulates pilA gene expression in Geobacter sulfurreducens Environmental Science and Pollution Research, 24, 25693-25701.

Gonzalez,G. Labastida,A. Jimenez-Jacinto,V. Vega-Alvarado,L. Olvera,M. Morett,E. Juarez,K. 2016. Global transcriptional start site mapping in Geobacter sulfurreducens during growth with two different electron acceptors Fems Microbiology Letters, 363, Article number fnw175.

Meysman,P. Collado-Vides,J. Morett,E. Viola,R. Engelen,K. Laukens,K. 2014. Structural properties of prokaryotic promoter regions correlate with functional features PLoS ONE, 9, e88717.

Gallarato,L.A. Sanchez,D.G. Olvera,L. Primo,E.D. Garrido,M.N. Beassoni,P.R. Morett,E. Lisa,A.T. 2014. Exopolyphosphatase of Pseudomonas aeruginosa is essential for the production of virulence factors and its expression is controlled by NtrC and PhoB, acting at two interspaced promoters Microbiology, 160, 406-417.

Balderas-Martinez,Y.I. Savageau,M. Salgado,H. Perez-Rueda,E. Morett,E. Collado-Vides,J. 2013. Transcription Factors in Escherichia coli Prefer the Holo Conformation PLoS ONE, 8, e65723 [correction 2013 vol 8 (8)].

Weiss,V. Medina-Rivera,A. Huerta,A.M. Santos-Zavaleta,A. Salgado,H. Morett,E. Collado-Vides,J. 2013. Evidence classification of high-throughput protocols and confidence integration in RegulonDB Database (Oxford), 2013, bas059.

Salgado,H. Peralta-Gil,M. Gama-Castro,S. Santos-Zavaleta,A. Muniz-Rascado,L. Garcia-Sotelo,J.S. Weiss,V. Solano-Lira,H. Martinez-Flores,I. Medina-Rivera,A. Salgado-Osorio,G. Alquicira-Hernandez,S. Alquicira-Hernandez,K. Lopez-Fuentes,A. Porron-Sotelo,L. Huerta,A.M. Bonavides-Martinez,C. Balderas-Martinez,Y.I. Pannier,L. Olvera,M. Labastida,A. Jimenez-Jacinto,V. Vega-Alvarado,L. Del Moral-Chavez,V. Hernandez-Alvarez,A. Morett,E. Collado-Vides,J. 2013. RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more Nucleic Acids Research, 41, D203-D213.

Aguilar,C. Escalante,A. Flores,N. de Anda,R. Riveros-McKay,F. Gosset,G. Morett,E. Bolivar,F. 2012. Genetic changes during a laboratory adaptive evolution process that allowed fast growth in glucose to an Escherichia coli strain lacking the major glucose transport system BMC Genomics, 13, 385.

Flores,H. Lin,S. Contreras-Ferrat,G. Cronan,J.E. Morett,E. 2012. Evolution of a new function in an esterase: simple amino acid substitutions enable the activity present in the larger paralog, BioH Protein Engineering Design & Selection, 25, 387-395.

Gallego-Hernandez,A.L. Hernandez-Lucas,I. De la Cruz,M.A. Olvera,L. Morett,E. Medina-Aparicio,L. Ramirez-Trujillo,J.A. Vazquez,A. Fernandez-Mora,M. Calva,E. 2012. Transcriptional regulation of the assT-dsbL-dsbI gene cluster depends on LeuO, H-NS and specific growth conditions in Salmonella enterica serovar Typhi IMSS-1 Journal of Bacteriology, 194, 2254-2264.

Saab-Rincon,G. Olvera,L. Olvera,M. Rudino-Pinera,E. Benites,E. Soberon,X. Morett,E. 2012. Evolutionary Walk between (beta/alpha)(8) Barrels: Catalytic Migration from Triosephosphate Isomerase to Thiamin Phosphate Synthase Journal of Molecular Biology, 416, 255-270.

Gama-Castro,S. Salgado,H. Peralta-Gil,M. Santos-Zavaleta,A. Muniz-Rascado,L. Solano-Lira,H. Jimenez-Jacinto,V. Weiss,V. Garcia-Sotelo,J.S. Lopez-Fuentes,A. Porron-Sotelo,L. Alquicira-Hernandez,S. Medina-Rivera,A. Martinez-Flores,I. Alquicira-Hernandez,K. Martinez-Adame,R. Bonavides-Martinez,C. Miranda-Rios,J. Huerta,A.M. Mendoza-Vargas,A. Collado-Torres,L. Taboada,B. Vega-Alvarado,L. Olvera,M. Olvera,L. Grande,R. Morett,E. Collado-Vides,J. 2011. RegulonDB version 7.0: transcriptional regulation of Escherichia coli K-12 integrated within genetic sensory response units (Gensor Units) Nucleic Acids Research, 39, D98-D105.

Massimelli,M.J. Sanchez,D.G. Buchieri,M.V. Olvera,L. Beassoni,P.R. Schweizer,H.P. Morett,E. Lisa,A.T. 2011. Choline catabolism, sigma(54) factor and NtrC are required for the full expression of the Pseudomonas aeruginosa phosphorylcholine phosphatase gene Microbiological Research, 166, 380-390.

Mendoza-Vargas,A. Olvera,L. Olvera,M. Grande,R. Vega-Alvarado,L. Taboada,B. Jimenez-Jacinto,V. Salgado,H. Juarez,K. Contreras-Moreira,B. Huerta,A.M. Collado-Vides,J. Morett,E. 2009. Genome-Wide Identification of Transcription Start Sites, Promoters and Transcription Factor Binding Sites in E. coli PLoS ONE, 4, e7526.

Olvera,L. Mendoza-Vargas,A. Flores,N. Olvera,M. Sigala,J.C. Gosset,G. Morett,E. Bolivar,F. 2009. Transcription Analysis of Central Metabolism Genes in Escherichia coli. Possible Roles of a38 in Their Expression, as a Response to Carbon Limitation PLoS ONE, 4, e7466.

Collado-Vides,J. Salgado,H. Morett,E. Gama-Castro,S. Jimenez-Jacinto,V. Martinez-Flores,I. Medina-Rivera,A. Muniz-Rascado,L. Peralta-Gil,M. Santos-Zavaleta,A. 2009. Bioinformatics resources for the study of gene regulation in bacteria Journal of Bacteriology, 191, 23-31.

Watanabe,R.L. Morett,E. Vallejo,E.E. 2008. Inferring modules of functionally interacting proteins using the Bond Energy Algorithm BMC Bioinformatics, 9, 285.

Morett,E. Saab-Rincon,G. Olvera,L. Olvera,M. Flores,H. Grande,R. 2008. Sensitive Genome-Wide Screen for Low Secondary Enzymatic Activities: The YjbQ Family Shows Thiamin Phosphate Synthase Activity Journal of Molecular Biology, 376, 839-853.

Gama-Castro,S. Jimenez-Jacinto,V. Peralta-Gil,M. Santos-Zavaleta,A. Penaloza-Spinola,M.I. Contreras-Moreira,B. Segura-Salazar,J. Muniz-Rascado,L. Martinez-Flores,I. Salgado,H. Bonavides-Martinez,C. Abreu-Goodger,C. Rodriguez-Penagos,C. Miranda-Rios,J. Morett,E. Merino,E. Huerta,A.M. Trevino-Quintanilla,L. Collado-Vides,J. 2008. RegulonDB (version 6.0): gene regulation model of Escherichia coli K-12 beyond transcription, active (experimental) annotated promoters and Textpresso navigation Nucleic Acids Research, 36 (Database issue), D120-D124.

Dago,A.E. Wigneshweraraj,S.R. Buck,M. Morett,E. 2007. A role for the conserved GAFTGA motif of AAA transcriptional activators in sensing promoter DNA conformation Journal of Biological Chemistry, 282, 1087-1097.

Hernandez-Urzua,E. Zamorano-Sanchez,D.S. Ponce-Coria,J. Morett,E. Grogan,S. Poole,R.K. Membrillo-Hernandez,J. 2007. Multiple regulators of the Flavohaemoglobin (hmp) gene of Salmonella enterica serovar Typhimurium include RamA, a transcriptional regulator conferring the multidrug resistance phenotype Archives of Microbiology, 187, 67-77.

Avonce,N. Mendoza-Vargas,A. Morett,E. Iturriaga,G. 2006. Insights on the evolution of trehalose biosynthesis BMC Evolutionary Biology, 6, 109.

Huerta,A.M. Francino,M.P. Morett,E. Collado-Vides,J. 2006. Selection for Unequal Densities of sigma(70) Promoter-Like Signals in Different Regions of Large Bacterial Genomes PLoS Genetics, 2, e185.

Aguilar-Diaz,H. Bobes,R.J. Carrero,J.C. Camacho-Carranza,R. Cervantes,C. Cevallos,M.A. Davila,G. Rodriguez-Dorantes,M. Escobedo,G. Fernandez,J.L. Fragoso,G. Gaytan,P. Garciarrubio,A. Gonzalez,V.M. Gonzalez,L. Jose,M.V. Jimenez,L. Laclette,J.P. Landa,A. Larralde,C. Morales-Montor,J. Morett,E. Ostoa-Saloma,P. Sciutto,E. Santamaria,R.I. Soberon,X. de la Torre P. Valdes,V. Yanez,J. 2006. The genome project of Taenia solium Parasitology International, 55, S127-S130.

Gaytan,P. Yanez,J. Grande,R. Morett,E. Soberon,X. 2005. Improving random mutagenesis by purification of the oligonucleotide variants Combinatorial Chemistry & High Throughput Screening, 8, 537-544.

Bordes,P. Wigneshweraraj,S.R. Chaney,M. Dago,A.E. Morett,E. Buck,M. 2004. Communication between Esigma, promoter DNA and the conserved threonine residue in the GAFTGA motif of the PspF sigma-dependent activator during transcription activation Molecular Microbiology, 54, 489-506.

Morett,E. Garciarrubio,A. 2004. Shuffled: a software suite that assists the analysis of recombinant products resulting from DNA shuffling Biotechniques, 37, 354-+.

Ciria,R. Abreu-Goodger,C. Morett,E. Merino,E. 2004. GeConT: gene context analysis Bioinformatics, 20, 2307-2308.

Morett,E. Korbel,J.O. Rajan,E. Saab-Rincon,G. Olvera,L. Olvera,M. Schmidt,S. Snel,B. Bork,P. 2003. Systematic discovery of analogous enzymes in thiamin biosynthesis Nature Biotechnology, 21, 790-795.

Chaney,M. Grande,R. Wigneshweraraj,S.R. Cannon,W. Casaz,P. Gallegos,M.T. Schumacher,J. Jones,S. Elderkin,S. Dago,A.E. Morett,E. Buck,M. 2001. Binding of transcriptional activators to sigma 54 in the presence of the transition state analog ADP-aluminum fluoride: insights into activator mechanochemical action Genes and Development, 15, 2282-2294.

Juarez,K. Flores,H. Davila,S. Olvera,L. Gonzalez,V. Morett,E. 2000. Reciprocal domain evolution within a transactivator in a restricted sequence space Proceedings of the National Academy of Sciences of the United States of America, 97, 3314-3318.

Morett,E. Bork,P. 1999. A novel transactivation domain in parkin Trends in Biochemical Sciences, 24, 229-231.

Barrios,H. Valderrama,B. Morett,E. 1999. Compilation and analysis of sigma(54)-dependent promoter sequences Nucleic Acids Research, 27, 4305-4313.

Grande,R.A. Valderrama,B. Morett,E. 1999. Suppression analysis of positive control mutants of NifA reveals two overlapping promoters for Klebsiella pneumoniae rpoN Journal of Molecular Biology, 294, 291-298.

Gonzalez,V. Olvera,L. Soberon,X. Morett,E. 1998. In vivo studies on the positive control function of NifA: a conserved hydrophobic amino acid patch at the central domain involved in transcriptional activation Molecular Microbiology, 28, 55-67.

Barrios,H. Grande,R. Olvera,L. Morett,E. 1998. In vivo genomic footprinting analysis reveals that the complex Bradyrhizobium japonicum fixRnifA promoter region is differently occupied by two distinct RNA polymerase holoenzymes Proceedings of the National Academy of Sciences of the United States of America, 95, 1014-1019.

Morett,E. Bork,P. 1998. Evolution of new protein function: recombinational enhancer Fis originated by horizontal gene transfer from the transcriptional regulator NtrC FEBS Letters, 433, 108-112.

Osuna,J. Soberon,X. Morett,E. 1997. A proposed architecture for the central domain of the bacterial enhancer-binding proteins based on secondary structure prediction and fold recognition Protein Science, 6, 543-555.

Del Rio,G. Morett,E. Soberon,X. 1997. Did cyclodextrin glycosyltransferases evolve from alpha-amylases? FEBS Letters, 416, 221-224.

Valderrama,B. Davalos,A. Girard,L. Morett,E. Mora,J. 1996. Regulatory proteins and cis-acting elements involved in the transcriptional control of Rhizobium etli reiterated nifH genes Journal of Bacteriology, 178, 3119-3126.

Barrios,H. Fischer,H.M. Hennecke,H. Morett,E. 1995. Overlapping promoters for two different RNA polymerase holoenzymes control Bradyrhizobium japonicum nifA expression Journal of Bacteriology, 177, 1760-1765 * .

Morett,E. Segovia,L. 1993. The sigma 54 bacterial enhancer-binding protein family: mechanism of action and phylogenetic relationship of their functional domains Journal of Bacteriology, 175, 6067-6074 * .

Morett,E. Fischer,H.M. Hennecke,H. 1991. Influence of oxygen on DNA binding, positive control, and stability of the Bradyrhizobium japonicum NifA regulatory protein Journal of Bacteriology, 173, 3478-3487 * .

Cannon,W.V. Kreutzer,R. Kent,H.M. Morett,E. Buck,M. 1990. Activation of the Klebsiella pneumoniae nifU promoter: identification of multiple and overlapping upstream NifA binding sites Nucleic Acids Research, 18, 1693-1701 * .

Morett,E. Kreutzer,R. Cannon,W. Buck,M. 1990. The influence of the Klebsiella pneumoniae regulatory gene nifL upon the transcriptional activator protein NifA Molecular Microbiology, 4, 1253-1258 * .

Morett,E. Buck,M. 1989. In vivo studies on the interaction of RNA polymerase-sigma 54 with the Klebsiella pneumoniae and Rhizobium meliloti nifH promoters. The role of NifA in the formation of an open promoter complex Journal of Molecular Biology, 210, 65-77 * .

Morett,E. Buck,M. 1988. NifA-dependent in vivo protection demonstrates that the upstream activator sequence of nif promoters is a protein binding site Proceedings of the National Academy of Sciences of the United States of America, 85, 9401-9405 * .

Morett,E. Cannon,W. Buck,M. 1988. The DNA-binding domain of the transcriptional activator protein NifA resides in its carboxy terminus, recognises the upstream activator sequences of nif promoters and can be separated from the positive control function of NifA Nucleic Acids Research, 16, 11469-11488 * .

Romero,D. Singleton,P.W. Segovia,L. Morett,E. Benbohlool,B. Palacios,R. Davila,G. 1988. Effect of Naturally Occurring nif Reiterations on Symbiotic Effectiveness in Rhizobium phaseoli. Applied and Environmental Microbiology, 54, 848-850 * .

Morett,E. Moreno,S. Espin,G. 1988. Transcription analysis of the three nifH genes of Rhizobium phaseoli with gene fusions MGG Molecular & General Genetics, 213, 499-504 * .

Calderon,J. Morett,E. Mora,J. 1985. Omega-amidase pathway in the degradation of glutamine in Neurospora crassa Journal of Bacteriology, 161, 807-809 * .

Morett,E. Moreno,S. Espin,G. 1985. Impaired nitrogen fixation and glutamine synthesis in methionine sulfoximine sensitive (MSs) mutants of Rhizobium phaseoli MGG Molecular & General Genetics, 200, 229-234 * .

Gonzalez,G. Labastida,A. Jimenez,V. Vega,L. Olvera,M. Morett,E. Juarez,K. 2015. Genes involved in electron transfer mechanism in g. Sulfurreducens en: Poggi-Varaldo,H.M. Environmental Biotechnology and Engineering-2014 vol 3. Mexico D.F.. Cinvestav. pags. 1269-1276

Hernandez-Eligio,J.A. Soto,L. Andrade,A. Olvera,L. Davila,S. Morett,E. Juarez-Lopez,K. 2015. Caracterización del sistema de dos componentes PilS/PilR y su mecanismo de regulación sobre el gen pilA en geobacter sulfurreducens en: Poggi-Varaldo,H.M. Environmental Biotechnology and Engineering-2014 vol 3. Mexico,D.F.. Cinvestav. pags. 1277-1287

Tapia,J.J. Morett,E. Vallejo,E.E. 2009. A clustering genetic algorithm for genomic data mining en: Studies in Computational Intelligence. Springer. pags. 249-275

Tapia,J.J. Vallejo,E.E. Morett,E. 2009. MOCEA: A multi-objective clustering evolutionary algorithm for inferring protein-protein functional interactions en: Proceedings of the 11th Annual Genetic and Evolutionary Computation Conference, GECCO-2009. ACM. pags. 1793-1794

Molina-Lozano,H. Vallejo-Clemente,E.E. Morett-Sanchez,J.E. 2008. DNA sequence analysis using fuzzy grammars en: IEEE International Conference on Fuzzy Systems. IEE. pags. 1915-1921

Martínez,M. Vallejo,E.E. Morett,E. 2007. Ancestral DNA sequence reconstruction using recursive genetic algorithms en: Lecture Notes in Computer Science, vol 4828 cap 4. pags. 390-400

Watanabe,R. Vallejo,E.E. Morett,E. 2006. Inferring functional coupling of proteins using the Evolutionary Bond Energy Algorithm en: Proceedings of the 2006 IEEE Symposium on Computational Intelligence in Bioinformatics and Computational Biology, CIBCB'06. pags. 400-405

Fernandez,J.C. Vallejo,E.E. Morett,E. 2006. Fuzzy C-means for inferring functional coupling of proteins from their phylogenetic profiles en: Computational Intelligence and Bioinformatics and Computational Biology, 2006. CIBCB '06. 2006 IEEE Symposium on. IEEE. pags. 1-8

Morett,E. Saab-Rincon,G. Merino,E. Bork,P. Rajan,E. Olvera,L.(error para maricela.olvera@mail.ibt.unam.mx) 2003. High rate of gene displacement in vitamin biosynthesis pathways en: Andrade,M.A. Bioinformatics and genomes: current perspectives. Norfolk,U.K.. Horizon Scientific Press. pags. 69-79

Morett.E. Saab,G. Olvera.L.(error para maricela.olvera@mail.ibt.unam.mx) Snel,B. Bork,P. 2002. Discovery of analogous enzymes in thiamin biosynthesis by anticorrelation en: Miyano,S. Genome Informatics 2002. Tokio. Universal Academy Press, Inc. pags. 365-366

Morett,E. 2001. Genetic regulation of nitrogen fixation: from ammonia ssimilation to protein evolution en: Nitrogen Fixation Research Center XX Anniversary. pags. 180-183

Patentes

J. E. Morett, L. Olvera R., M. Olvera R., E. Rajan-Koil M., G. Saab R., P. Bork, D. Korbe-Larz, S. Schmidt y D.H.P. Snel 2004 Bioinformatic Method.Copropiedad de la UNAM y el laboratorio Europeo de Biología Molecular PCT.

* Indica publicación con otra institución de adscripción