. Instituto de Biotecnologia UNAM

IBT-UNAM : Dra. Leonor Perez Martinez

Dra. Leonor Perez Martinez

Jefe del Departamento Medicina Molecular y Bioprocesos
Líder Académico »» Grupo
Investigador
Tutor de Maestría y Doctorado
Nivel II del SNI
Líneas de investigación

email: leonor @ibt.unam.mx
Teléfonos

Oficina +52 (777) 329-1777 ext 38310.
desde la CDMX 562-27777 ext 38310
red UNAM 38310

Laboratorio +52 (777) 329-1777 ext 38259.
desde la CDMX 562-27777 ext 38259
red UNAM 38259

- Licenciatura: Biología, Fac. de Ciencias-UNAM (1986)
- Maestría: en Ciencias, Instituto Weizmann de Ciencia, Israel (1988)
- Doctorado: Biología Celular, Instituto Friedrich Miescher, Basilea, Suiza (1993)
- Estancia de Investigación: Estudiante visitante, Instituto Weizmann de Ciencia, Israel (1989)
- Estancia de Investigación: en el Biozentrum, Universidad de Basilea, Suiza (1990)
- Estancia de Investigación: posdoctoral en el Colegio de Medicina, Universidad de Vermont USA (2000)

Estudiantes

M.C. Norma Angelica Garduño "Estudio de la función del factor de transcripción klf10 durante la neurogénesis hipotalámica embrionaria."

M.C. Cristina Elizabeth Ramírez

Q.F.B. Gloria Guadalupe Najera

Maria Elizabeth Santana

M.C. Maria del Sol Díaz de León "Impacto del ambiente enriquecido en la neurogénesis hipotalámica para la regulación del balance energético"

Carlos Humberto Martinez

M.C. Roberto Carlos Licea

Biol. Bolivar Jesus Arcos

M.C. Rubiceli Manzo

Biol. Eladio Cortes

Biol. Kenya Paola Romero

Elisa Medrano

Lic. Ruben Asgard Castorena

Publicaciones recientes

Arango-De la Pava LD Zamilpa,A. Trejo-Espino,J.L. Dominguez-Mendoza,B.E. Jimenez-Ferrer,E. Perez-Martinez,L. Trejo-Tapia,G. 2021. Synergism and Subadditivity of Verbascoside-Lignans and -Iridoids Binary Mixtures Isolated from Castilleja tenuiflora Benth. on NF-kB/AP-1 Inhibition Activity Molecules, 26, 547.

Licea-Cejudo,R.C. Arenas-Sandoval,L.K. Salazar-Leon,J. Martinez-Martinez,M.V. Carreon-Rodriguez,A. Pedraza-Alva,G. Perez-Martinez,L. 2020. A dysfunctional family environment and a high body fat percentage negatively affect telomere length in Mexican boys aged 8-10 years Acta Paediatrica, 109, 2091-2098.

Sanchez,N.C. Medrano-Jimenez,E. Aguilar-Leon,D. Perez-Martinez,L. Pedraza-Alva,G. 2020. Tumor Necrosis Factor-Induced miR-146a Upregulation Promotes Human Lung Adenocarcinoma Metastasis by Targeting Merlin DNA and Cell Biology, 39, 484-497.

Salazar-Leon,J. Valdez-Hernandez,A.L. Garcia-Jimenez,S. Roman-Dominguez,L. Huanosta-Murillo,E. Bonifaz,L.C. Perez-Martinez,L. Pedraza-Alva,G. 2019. Nlrp1b1 negatively modulates obesity-induced inflammation by promoting IL-18 production Scientific Reports, 9, 13815.

Ramirez-Serrano,C.E. Jimenez-Ferrer,E. Herrera-Ruiz,M. Zamilpa,A. Vargas-Villa,G. Ramirez-Carreto,R.J. Chavarria,A. Tortoriello,J. Pedraza-Alva,G. Perez-Martinez,L. 2019. A Malva parviflora's fraction prevents the deleterious effects resulting from neuroinflammation Biomedicine and Pharmacotherapy, 118, 109349.

Medrano-Jimenez,E. Jimenez-Ferrer Carrillo,I. Pedraza-Escalona,M. Ramirez-Serrano,C.E. Alvarez-Arellano,L. Cortes-Mendoza,J. Herrera-Ruiz,M. Jimenez-Ferrer,E. Zamilpa,A. Tortoriello,J. Pedraza-Alva,G. Perez-Martinez,L. 2019. Malva parviflora extract ameliorates the deleterious effects of a high fat diet on the cognitive deficit in a mouse model of Alzheimer's disease by restoring microglial function via a PPAR-gamma-dependent mechanism Journal of Neuroinflammation, 16, 143.

Villasenor,T. Madrid-Paulino,E. Maldonado-Bravo,R. Perez-Martinez,L. Pedraza-Alva,G. 2019. Mycobacterium bovis BCG promotes IL-10 expression by establishing a SYK/PKCalpha/beta positive autoregulatory loop that sustains STAT3 activation Pathogens and Disease, 77, ftz032.

Pedraza-Alva,G. Ramirez-Serrano,C.E. Pedraza,F. Flores-Vallejo,R.C. Villarreal,M.L. Perez-Martinez,L. 2019. From traditional remedies to cutting-edge medicine: using ancient Mesoamerican knowledge to address complex disorders relevant to psychoneuroimmunology Brain, Behavior, and Immunity, 79, 3-5.

Villanueva-Flores,F. Miranda-Hernandez,M. Flores-Flores,J.O. Porras-Sanjuanico,A. Hu,H. Perez-Martinez,L. Ramirez,O.T. Palomares,L.A. 2019. Poly(vinyl alcohol co-vinyl acetate) as a novel scaffold for mammalian cell culture and controlled drug release Journal of Materials Science, 54, 7867-7882.

Ramirez-Carreto,S. Perez-Garcia,E.I. Salazar-Garcia,S.I. Bernaldez-Sarabia,J. Licea-Navarro,A. Rudino-Pinera,E. Perez-Martinez,L. Pedraza-Alva,G. Rodriguez-Almazan,C. 2019. Identification of a pore-forming protein from sea anemone Anthopleura dowii Verrill (1869) venom by mass spectrometry Journal of Venomous Animals and Toxins Including Tropical Diseases, 25, e144118.

Alvarez-Arellano,L. Pedraza-Escalona,M. Blanco-Ayala,T. Camacho-Concha,N. Cortes-Mendoza,J. Perez-Martinez,L. Pedraza-Alva,G. 2018. Autophagy impairment by caspase-1-dependent inflammation mediates memory loss in response to beta-Amyloid peptide accumulation Journal of Neuroscience Research, 96, 234-246.

Villasenor,T. Madrid-Paulino,E. Maldonado-Bravo,R. Urban-Aragon,A. Perez-Martinez,L. Pedraza-Alva,G. 2017. Activation of the Wnt Pathway by Mycobacterium tuberculosis: A Wnt-Wnt Situation Frontiers in Immunology, 8, 50.

Miquelajauregui,A. Sandoval-Schaefer,T. Martinez-Armenta,M. Perez-Martinez,L. Carabez,A. Zhao,Y. Heide,M. Alvarez-Bolado,G. Varela-Echavarria,A. 2015. LIM homeobox protein 5 (Lhx5) is essential for mamillary body development Frontiers in Neuroanatomy, 9, 136.

Perez-Garcia,E.I. Meza-Sosa,K.F. Lopez-Sevilla,Y. Camacho-Concha,N. Sanchez,N.C. Perez-Martinez,L. Pedraza-Alva,G. 2015. Merlin negative regulation by miR-146a promotes cell transformation Biochemical and Biophysical Research Communications, 468, 594-600.

Pedraza-Alva,G. Perez-Martinez,L. Valdez-Hernandez,L. Meza-Sosa,K.F. Ando-Kuri,M. 2015. Negative regulation of the inflammasome: keeping inflammation under control Immunological Reviews, 265, 231-257.

Martinez-Armenta,M. de Leon-Guerrero,S.D. Catalan,A. Alvarez-Arellano,L. Uribe,R.M. Subramaniam,M. Charli,J.L. Perez-Martinez,L. 2015. TGFbeta2 regulates hypothalamic Trh expression through the TGFbeta inducible early gene-1 (TIEG1) during fetal development Molecular and Cellular Endocrinology, 400, 129-139.

Meza-Sosa,K.F. Perez-Garcia,E.I. Camacho-Concha,N. Lopez-Gutierrez,O. Pedraza-Alva,G. Perez-Martinez,L. 2014. MiR-7 Promotes Epithelial Cell Transformation by Targeting the Tumor Suppressor KLF4 PLoS ONE, 9, e103987.

Meza-Sosa,K.F. Pedraza-Alva,G. Perez-Martinez,L. 2014. microRNAs: key triggers of neuronal cell fate Frontiers in Cellular Neuroscience, 8, 175.

Cortes-Mendoza,J. Leon-Guerrero,S.D. Pedraza-Alva,G. Perez-Martinez,L. 2013. Shaping synaptic plasticity: the role of activity-mediated epigenetic regulation on gene transcription International Journal of Developmental Neuroscience, 31, 359-369.

Carreon-Rodriguez,A. Perez-Martinez,L. 2012. Clinical implications of thyroid hormones effects on nervous system development.Pediatric endocrinology reviews, 9, 644-649 [erratum en 9 (4) 744].

Meza-Sosa,K.F. Valle-Garcia,D. Pedraza-Alva,G. Perez-Martinez,L. 2012. Role of microRNAs in central nervous system development and pathology Journal of Neuroscience Research, 90, 1-12.

Guerra-Crespo,M. Perez-Monter,C. Janga,S.C. Castillo-Ramirez,S. Gutierrez-Rios,R.M. Joseph-Bravo,P. Perez-Martinez,L. Charli,J.L. 2011. Transcriptional profiling of fetal hypothalamic TRH neurons BMC Genomics, 12, 222.

Diaz de Leon-Guerrero,S. Pedraza-Alva,G. Perez-Martinez,L. 2011. In sickness and in health: the role of methyl-CpG binding protein 2 in the central nervous system European Journal of Neuroscience, 33, 1563-1574.

Perez-Monter,C. Martinez-Armenta,M. Miquelajauregui,A. Furlan-Magaril,M. Varela-Echavarria,A. Recillas-Targa,F. May,V. Charli,J.L. Perez-Martinez,L. 2011. The Kruppel-like factor 4 controls biosynthesis of thyrotropin-releasing hormone during hypothalamus development Molecular and Cellular Endocrinology, 333, 127-133.

Carreon-Rodriguez,A. Charli,J.L. Perez-Martinez,L. 2009. T3 differentially regulates TRH expression in developing hypothalamic neurons in vitro Brain Research, 1305, 20-30.

Pedraza-Alva,G. Zingg,J.M. Donda,A. Perez-Martinez,L. 2009. Estrogen receptor regulates MyoD gene expression by preventing AP-1-mediated repression Biochemical and Biophysical Research Communications, 389, 360-365.

Cote-Velez,A. Perez-Martinez,L. Charli,J.L. Joseph-Bravo,P. 2008. The PKC and ERK/MAPK Pathways Regulate Glucocorticoid Action on TRH Transcription Neurochemical Research, 33, 1582-1591.

Ubieta,R. Uribe,R.M. Gonzalez,J.A. Garcia-Vazquez,A. Perez-Monter,C. Perez-Martinez,L. Joseph-Bravo,P. Charli,J.L. 2007. BDNF up-regulates pre-pro-TRH mRNA expression in the fetal/neonatal paraventricular nucleus of the hypothalamus. Properties of the transduction pathway Brain Research, 1174, 28-38.

Jaworski,D.M. Perez-Martinez,L. 2006. Tissue Inhibitor of Metalloproteinase-2 (TIMP-2) expression is regulated by multiple neural differentiation signals Journal of Neurochemistry, 98, 234-247 * .

Perez-Martinez,L. Jaworski,D.M. 2005. Tissue inhibitor of metalloproteinase-2 promotes neuronal differentiation by acting as an anti-mitogenic signal Journal of Neuroscience, 25, 4917-4929.

Cote-Velez,A. Perez-Martinez,L. Diaz-Gallardo,M.Y. Perez-Monter,C. Carreon,A. Charli,J.L. Joseph-Bravo,P. 2005. Dexamethasone repressed cAMP rapid upregulation of TRH gene transcription. Identification of a composite GRE and a CRE in TRH promoter Journal of Molecular Endocrinology, 34, 177-197.

Guerra-Crespo,M. Charli,J.L. Rosales-Garcia,V. Pedraza-Alva,G. Perez-Martinez,L. 2003. Polyethylenimine improves the transfection efficiency of primary cultures of post-mitotic rat fetal hypothalamic neurons Journal of Neuroscience Methods, 127, 179-192.

Joseph-Bravo,P. Perez-Martinez,L. Lezama,L. Morales-Chapa,C. Charli,J.L. 2002. An improved method for the expression of TRH in serum-supplemented primary cultures of fetal hypothalamic cells Brain Research Protocols, 9, 93-104.

Guerra-Crespo,M. Ubieta,R. Joseph-Bravo,P. Charli,J.L. Perez-Martinez,L. 2001. BDNF increases the early expression of TRH mRNA in fetal TrkB+ hypothalamic neurons in primary culture European Journal of Neuroscience, 14, 483-494.

Perez-Martinez,L. Charli,J. Joseph-Bravo,P. 2001. Development of pro-TRH gene expression in primary cultures of fetal hypothalamic cells Developmental Brain Research, 130, 73-81.

Niquet,J. Perez-Martinez,L. Guerra,M. Grouselle,D. Joseph-Bravo,P. Charli,J. 2000. Extracellular matrix proteins increase the expression of pro-TRH and pro-protein convertase PC1 in fetal hypothalamic neurons in vitro Developmental Brain Research, 120, 49-56.

de Gortari,P. Mendez,M. Rodriguez-Keller,I. Perez-Martinez,L. Joseph-Bravo,P. 2000. Acute ethanol administration induces changes in TRH and proenkephalin expression in hypothalamic and limbic regions of rat brain Neurochemistry International, 37, 483-496.

Perez-Martinez,L. Uribe,R.M. Sanchez,E. Carreon-Rodriguez,A. Chavez,L. Zacarias,M. Joseph-Bravo,P. Charli,J.L. 1999. Regulation of TRH biosynthesis in the paraventricular nucleus of rodent hypothalamus Current topics in neurochemistry, 2, 79-88.

Joseph-Bravo,P. Uribe,R.M. Vargas,M.A. Perez-Martinez,L. Zoeller,T. Charli,J.L. 1998. Multifactorial modulation of TRH metabolism Cellular & Molecular Neurobiology, 18, 231-247.

Charli,J.L. Vargas,M.A. Cisneros,M. de Gortari,P. Baeza,M.A. Jasso,P. Bourdais,J. Perez,L. Uribe,R.M. Joseph-Bravo,P. 1998. TRH inactivation in the extracellular compartment: role of pyroglutamyl peptidase II.Neurobiology (Bp.), 6, 45-57.

Perez-Martinez,L. Carreon-Rodriguez,A. Gonzalez-Alzati,M.E. Morales,C. Charli,J.L. Joseph-Bravo,P. 1998. Dexamethasone rapidly regulates TRH mRNA levels in hypothalamic cell cultures: interaction with the cAMP pathway Neuroendocrinology, 68, 345-354.

Perez,L. Urich,M. Paasinen,A. Senften,M. Meili,R. Ballmerhofer,K. 1995. Domains in Middle-T Antigen That Cooperate in Polyomavirus-Mediated Oncogenic Transformation Virology, 208, 26-37 * .

Uribe,R.M. Perez-Martinez,L. Covarrubias,M.D. Gomez,O. Covarrubias,L. Charli,J.L. Joseph-Bravo,P. 1995. Phorbol ester or cAMP enhance thyrotropin-releasing hormone mRNA in primary cultures of hypothalamic cells Neuroscience Letters, 201, 41-44.

Perez,L. Paasinen,A. Schnierle,B. Kach,S. Senften,M. Ballmerhofer,K. 1993. Mitosis-Specific Phosphorylation of Polyomavirus Middle-Sized Tumor-Antigen and Its Role During Cell-Transformation Proceedings of the National Academy of Sciences of the United States of America, 90, 8113-8117 * .

Jaffe,C.L. Perez,M.L. Sarfstein,R. 1990. Leishmania-Tropica Experimental Parasitology, 70, 12-24 * .

Jaffe,C.L. Perez,L.M. Schnur,L.F. 1990. Lipophosphoglycan and Secreted Acid-Phosphatase of Leishmania-Tropica Share Species-Specific Epitopes Molecular and Biochemical Parasitology, 41, 233-240 * .

Alvarez-Arellano,L. Diaz de Leon-Guerrero,S. Meza-Sosa,K.F. Jimenez-Ferrer C.,I. Perez-Martinez,L. 2013. Neurodegenerative disorders and inflammation en: Ferat-Osorio,E. Molecular aspects of inflammation. Kerala. Research Signpost. pags. 173-207

Perez-Martinez,L. Pedraza-Alva,G. Ferat-Osorio,E. 2013. Molecular aspects of inflammation Kerala:. Research Signpost. 231 p.

Carreon-Rodriguez,A. Perez-Martinez,L. 2012. Role of Thyroid Hormones on Hypothalamus Development and Function en: Berhardt,L.V. Advances in Medicine and Biology vol 49. New York. Nova Science Publishers. pags. 1-20

Perez-Martinez,L. Pedraza-Alva,G. 2012. Cell signaling: From non-specific bands to posttranslational modifications-mediated protein-protein interactions en: *isabelg Tools to Understand Protein-Protein Interactions. Kerala. Transworld Research Network. pags. 21-40

Joseph-Bravo,P. Cote-Velez,A. Perez-Martinez,L. 2006. Integration of Neuroendocrine Signals that Regulate the Activity of Hypophysiotropic Peptides en: *joseph Molecular Endocrinology. Kerala, India,. Research Signpost. pags. 1-24

Perez-Martinez,L. Charli,J.L. 2006. Factors Involved in the Establishment of Hypothalamic Neuroendocrine Phenotypes en: *joseph Molecular Endocrinology. Kerala, India,. Research Signpost. pags. 127-147

Otras Publicaciones

Licea-Cejudo,R.C. Pedraza-Alva,G. Perez-Martinez,L. 2018. Obesidad infantil: Crónica de una vejez anunciada Biotecnología en Movimiento.Revista de divulgación del Instituto de Biotecnología de la UNAM, 12, 17-19.

Perez-Martinez,L. Martinez-Armenta,M. Cortes-Mendoza,J. 2015. Del ADN a la neurona: un vistazo a la expresión génica del cerebro Biotecnología en Movimiento.Revista de divulgación del Instituto de Biotecnología de la UNAM, 3, 5-8.

Carreon-Rodriguez,A. Perez-Martinez,L. 2013. El papel de los receptores de hormonas tiroideas en el desarrollo del sistema nervioso eNeurobiologia, 4, 240513.

Meza-Sosa,K.F. Valle-Garcia,D. Pedraza-Alva,G. Perez-Martinez,L. 2013. MicroARNs, los pequeños grandes actores del sistema nervioso Ciencia, Revista de la Academia Mexicana de Ciencia, 64, 79-86.

Carreon-Rodriguez,A. Perez-Martinez,L. Joseph-Bravo,P. 2008. La participación de las hormonas tiroideas en el desarrollo y función del sistema nervioso.Facultad de Medicina.Revista Actualidades de Posgrado para el Médico General, 12, 9-12.

Guerra-Crespo,M. Charli,J.L. Perez-Martinez,L. 2005. Los arreglos de DNA: explorando la expresion genetica del cerebro Ciencia, Revista de la Academia Mexicana de Ciencia, 56, 67-76.

* Indica publicación con otra institución de adscripción