. Instituto de Biotecnologia UNAM

IBT-UNAM : Dr. Miguel Angel Vargas Suarez

Dr. Miguel Angel Vargas Suarez

Investigador Adscrito al Departamento
Nivel I del SNI
Secretaría Académica

email: miguel @ibt.unam.mx
Teléfonos
Oficina (52+55) 562-27673 ;

- Licenciatura: Biología, ENEP-Iztacala-UNAM (1984)
- Maestría: en Investigacion Biomedica Basica, CEINGEBI-UNAM (1988)
- Doctorado: en Investigacion Biomedica Basica, CEINGEBI-UNAM (1991)
- Mencion honorífica en examen de Licenciatura (1984)
- Mencion honorífica en examen de Maestría (1988)

Publicaciones recientes

Alvarez-Salas,E. Alcantara-Alonso,V. Matamoros-Trejo,G. Vargas,M.A. Morales-Mulia,M. Gortari,P. 2015. Mediobasal hypothalamic and adenohypophyseal TRH-degrading enzyme (PPII) is down-regulated by zinc deficiency International Journal of Developmental Neuroscience, 46, 115-124.

Lazcano,I. Uribe,R.M. Martinez-Chavez,E. Vargas,M.A. Matziari,M. Joseph-Bravo,P. Charli,J.L. 2012. Pyroglutamyl peptidase II inhibition enhances the analeptic effect of thyrotropin releasing hormone in the rat medial septum Journal of Pharmacology and Experimental Therapeutics, 342, 222-231.

Pascual,I. Gomez,H. Pons,T. Chappe,M. Vargas,M.A. Valdes,G. Lopez,A. Saroyan,A. Charli,J.L. Chavez,M.D. 2011. Effect of divalent cations on the porcine kidney cortex membrane-bound form of dipeptidyl peptidase IV International Journal of Biochemistry and Cell Biology, 43, 363-371.

Uribe,R.M. Cisneros,M. Vargas,M.A. Lezama,L. Cote-Velez,A. Joseph-Bravo,P. Charli,J.L. 2011. The systemic inhibition of nitric oxide production rapidly regulates TRH mRNA concentration in the paraventricular nucleus of the hypothalamus and serum TSH concentration. Studies in control and cold-stressed rats Brain Research, 1367, 188-197.

Sanchez,E. Vargas,M.A. Singru,P.S. Pascual,I. Romero,F. Fekete,C. Charli,J.L. Lechan,R.M. 2009. Tanycyte Pyroglutamyl Peptidase II Contributes to Regulation of the Hypothalamic-Pituitary-Thyroid Axis through Glial-Axonal Associations in the Median Eminence Endocrinology, 150, 2283-2291.

Rodriguez-Molina,V. Vargas,M.A. Joseph-Bravo,P. Charli,J.L. 2009. NMDA receptor up-regulates pyroglutamyl peptidase II activity in the rat hippocampus Neuroscience Letters, 449, 211-214.

Cruz,R. Vargas,M.A. Uribe,R.M. Pascual,I. Lazcano,I. Yiotakis,A. Matziari,M. Joseph-Bravo,P. Charli,J.L. 2008. Anterior pituitary pyroglutamyl peptidase II activity controls TRH-induced prolactin release Peptides, 29, 1953-1964.

de Gortari,P. Vargas,M.A. Martinez,A. Garcia-Vazquez,A.I. Uribe,R.M. Chavez-Gutierrez,L. Magdaleno,V. Boileau,G. Charli,J.L. Joseph-Bravo,P. 2007. Stage-specific Modulation of Neprilysin and Aminopeptidase N in the Limbic System During Kindling Progression Journal of Molecular Neuroscience, 33, 252-261.

Chavez-Gutierrez,L. Bourdais,J. Aranda,G. Vargas,M.A. Matta-Camacho,E. Ducancel,F. Segovia,L. Joseph-Bravo,P. Charli,J.L. 2005. A truncated isoform of pyroglutamyl aminopeptidase II produced by exon extension has dominant-negative activity Journal of Neurochemistry, 92, 807-817.

Benoit,A. Vargas,M.A. Desgroseillers,L. Boileau,G. 2004. Endothelin-converting enzyme-like 1 (ECEL1) is present both in the plasma membrane and in the endoplasmic reticulum Biochemical Journal, 380, 881-888 * .

Vargas,M.A. St Louis,M. Desgroseillers,L. Charli,J.L. Boileau,G. 2003. Parathyroid Hormone-Related Protein(1-34) Regulates Phex Expression in Osteoblasts Through the Protein Kinase A Pathway Endocrinology, 144, 4876-4885.

Vargas,M.A. Uribe,R.M. Cisneros,M. Romero,F. Gonzalez,S. Joseph-Bravo,P. Charli,J.L. 2002. Thyrotropin-releasing hormone regulates the diurnal variation of pyroglutamyl aminopeptidase II activity in the male rat adenohypophysis European Journal of Endocrinology, 147, 363-369.

Vargas,M.A. Cisneros,M. Joseph-Bravo,P. Charli,J.L. 2002. Thyrotropin-releasing hormone-induced down-regulation of pyroglutamyl aminopeptidase II activity involves L-type calcium channels and cam kinase activities in cultures of adenohypophyseal cells Journal of Neuroendocrinology, 14, 184-193.

Vargas,M.A. Cisneros,M. Joseph-Bravo,P. Charli,J.L. 2000. Regulation of adenohypophyseal pyroglutamyl aminopeptidase II activity by thyrotropin-releasing hormone and phorbol esters Endocrine, 13, 267-272.

Joseph-Bravo,P. Uribe,R.M. Vargas,M.A. Perez-Martinez,L. Zoeller,T. Charli,J.L. 1998. Multifactorial modulation of TRH metabolism Cellular & Molecular Neurobiology, 18, 231-247.

Vargas,M.A. Bourdais,J. Sanchez,S. Uriostegui,B. Moreno,E. Joseph-Bravo,P. Charli,J.L. 1998. Multiple hypothalamic factors regulate pyroglutamyl peptidase II in cultures of adenohypophyseal cells: role of the cAMP pathway Journal of Neuroendocrinology, 10, 199-206.

Charli,J.L. Vargas,M.A. Cisneros,M. de Gortari,P. Baeza,M.A. Jasso,P. Bourdais,J. Perez,L. Uribe,R.M. Joseph-Bravo,P. 1998. TRH inactivation in the extracellular compartment: role of pyroglutamyl peptidase II.Neurobiology (Bp.), 6, 45-57.

Covarrubias,L. Redondo,J.L. Vargas,M.A. Uribe,R.M. Mendez,M. Joseph-Bravo,P. Charli,J.L. 1994. In vitro TRH release from hypothalamus slices varies during the diurnal cycle Neurochemical Research, 19, 845-850.

Vargas,M.A. Joseph-Bravo,P. Charli,J.L. 1994. Thyrotropin-releasing hormone downregulates pyroglutamyl peptidase II activity in adenohypophyseal cells Neuroendocrinology, 60, 323-330.

Joseph-Bravo,P. Fresan,M. Cisneros,M. Vargas,M.A. Charli,J.L. 1994. Pyroglutamyl peptidase II activity is not in the processes of bulbospinal TRHergic neurons Neuroscience Letters, 178, 243-246.

Vargas,M.A. Cisneros,M. Herrera,J. Joseph-Bravo,P. Charli,J.L. 1992. Regional distribution of pyroglutamyl peptidase II in rabbit brain, spinal cord, and organs Peptides, 13, 255-260.

Vargas,M.A. Herrera,J. Uribe,R.M. Charli,J.L. Joseph-Bravo,P. 1992. Ontogenesis of pyroglutamyl peptidase II activity in rat brain, adenohypophysis and pancreas Developmental Brain Research, 66, 251-256.

Cruz,C. Charli,J.L. Vargas,M.A. Joseph-Bravo,P. 1991. Neuronal localization of pyroglutamate aminopeptidase II in primary cultures of fetal mouse brain Journal of Neurochemistry, 56, 1594-1601.

Charli,J.L. Mendez,M. Vargas,M.A. Cisneros,M. Assai,M. Joseph-Bravo,P. Wilk,S. 1989. Pyroglutamyl peptidase II inhibition specifically increases recovery of TRH released from rat brain slices Neuropeptides, 14, 191-196.

Charli,J.L. Cruz,C. Ponce,G. Vargas,M.A. Mendez,M. Cisneros,M. Pasten,J. Joseph-Bravo,P. 1989. Physiological relevance of pyroglutamate aminopeptidase II Annals of the New York Academy of Sciences, 553, 563-564.

Charli,J.L. Cruz,C. Vargas,M. Joseph-Bravo,P. 1988. The narrow specificity pyroglutamate aminopeptidase degrading TRH in brain is an ectoenzyme Neurochemistry International, 13, 237-242.

Mendez,M. Joseph-Bravo,P. Cisneros,M. Vargas,M.A. Charli,J.L. 1987. Regional distribution of in vitro release of thyrotropin releasing hormone in rat brain Peptides, 8, 291-298.

Vargas,M. Mendez,M. Cisneros,M. Joseph-Bravo,P. Charli,J.L. 1987. Regional distribution of the membrane-bound pyroglutamate amino peptidase-degrading thyrotropin-releasing hormone in rat brain Neuroscience Letters, 79, 311-314.

Torres,H. Charli,J.L. Vargas,M.A. Gonzalez-Noriega,A. Joseph-Bravo,P. 1986. Subcellular distribution of the enzymes degrading Thyrotropin releasing hormone and metabolites in rat brain Neurochemistry International, 9, 103-110.

Charli,J.L. Pascual,I. Cruz,R. Vargas,M.A. 2006. Post-Secretory Inactivation of Peptides in the Hypotalamic-Adenohypophyseal Axis. Focus on Pyroglutamyl Peptidase Ii, the Thyrotropin Releasing Hormone Inactivating Enzyme en: *joseph Molecular Endocrinology. Kerala, India,. Research Signpost. pags. 39-64

* Indica publicación con otra institución de adscripción