IBT-UNAM : Dra. Patricia Leon Mejía
Dra. Patricia Leon Mejía Grupo
Departamento de Biología Molecular de Plantas
Líneas de investigación
email: patricia @ibt.unam.mx
Teléfonos
Oficina +52 (777) 329-1856 red UNAM 27856 +52 (777) 311-4900 ext 292 Laboratorio +52 (777) 329-1667 red UNAM 27667 +52 (777) 311-4900 ext 292
- Licenciatura: Biología, Fac. de Ciencias-UNAM (1981)
Howard Hughes Medical Institute International Research Scholar 2002-2006 (2002)
Estudiantes Leslie Acevedo
Domitzel Zagal
M.C. Luis Alberto De Luna
Biol. Constanza Enriquez
Q.F.B. Jimena Bellido
Biol. Adriana Lara
Alejandra Dagmara Rivera "Análisis de los elementos en cis del promotor de ABI4 involucrados en la regulación por azúcares"
M.C. Marel Chenge
M.C. Julio Salvador Sierra
Biol. Arihel de Jesús Hernández
Biol. Pablo Isai Hernandez
Publicaciones recientes
Escobar-Tovar,L. Sierra,J. Hernandez-Munoz,A. McQuinn,R.P. Mathioni,S. Cordoba,E. Colas des Francs-Small,C. Meyers,B.C. Pogson,B. Leon,P.
2020. Deconvoluting apocarotenoid-mediated retrograde signaling networks regulating plastid translation and leaf development Plant Journal, Dec 19 Online ahead of print, .
Wang,J.Z. Lei,Y. Xiao,Y. He,X. Liang,J. Jiang,J. Dong,S. Ke,H. Leon,P. Zerbe,P. Xiao,Y. Dehesh,K.
2020. Uncovering the functional residues of Arabidopsis isoprenoid biosynthesis enzyme HDS Proceedings of the National Academy of Sciences of the United States of America, 117, 355-361.
Lopez-Bucio,J.S. Salmeron-Barrera,G.J. Ravelo-Ortega,G. Raya-Gonzalez,J. Leon,P. de la Cruz,H.R. Campos-Garcia,J. Lopez-Bucio,J. Guevara-Garcia,A.A.
2019. Mitogen-activated protein kinase 6 integrates phosphate and iron responses for indeterminate root growth in Arabidopsis thaliana Planta, 250, 1177-1189.
de Luna-Valdez,L.A. Villasenor-Salmeron,C.I. Cordoba,E. Vera-Estrella,R. Leon-Mejia,P. Guevara-Garcia,A.A.
2019. Functional analysis of the Chloroplast GrpE (CGE) proteins from Arabidopsis thaliana Plant Physiology And Biochemistry, 139, 293-306.
Chenge-Espinosa,M. Cordoba,E. Romero-Guido,C. Toledo-Ortiz,G. Leon,P.
2018. Shedding light on the Methylerythritol phosphate (MEP)-pathway: long hypocothyl 5 (HY5)/ phytochrome-interacting factors (PIFs) transcription factors modulating key limiting steps Plant Journal, 96, 828-841.
Lopez-Bucio,J.S. Raya-Gonzalez,J. Ravelo-Ortega,G. Ruiz-Herrera,L.F. Ramos-Vega,M. Leon,P. Lopez-Bucio,J. Guevara-Garcia,A.A.
2018. Mitogen activated protein kinase 6 and MAP kinase phosphatase 1 are involved in the response of Arabidopsis roots to L-glutamate Plant Molecular Biology, 96, 339-351.
Hou,X. Rivers,J. Leon,P. McQuinn,R.P. Pogson,B.J.
2016. Synthesis and Function of Apocarotenoid Signals in Plants Trends in Plant Science, 21, 792-803.
Ramos-Vega,M. Guevara-Garcia,A. Llamas,E. Sanchez-Leon,N. Olmedo-Monfil,V. Vielle-Calzada,J.P. Leon,P.
2015. Functional analysis of the Arabidopsis thaliana CHLOROPLAST BIOGENESIS 19 pentatricopeptide repeat editing protein New Phytologist, 208, 430-441.
Cordoba,E. Aceves-Zamudio,D.L. Hernandez-Bernal,A.F. Ramos-Vega,M. Leon,P.
2015. Sugar regulation of SUGAR TRANSPORTER PROTEIN 1 (STP1) expression in Arabidopsis thaliana Journal of Experimental Botany, 66, 147-159.
de Luna-Valdez,L.A. Martinez-Batallar,A.G. Hernandez-Ortiz,M. Encarnacion-Guevara,S. Ramos-Vega,M. Lopez-Bucio,J.S. Leon,P. Guevara-Garcia,A.A.
2014. Data for a comparative proteomic analysis of chloroplast biogenesis (clb) mutants Data in Brief, 1, 15-18.
de Luna-Valdez,L.A. Martinez-Batallar,A.G. Hernandez-Ortiz,M. Encarnacion-Guevara,S. Ramos-Vega,M. Lopez-Bucio,J.S. Leon,P. Guevara-Garcia,A.A.
2014. Proteomic analysis of chloroplast biogenesis (clb) mutants uncovers novel proteins potentially involved in the development of Arabidopsis thaliana chloroplasts Journal of Proteomics, 111, 148-164.
Avendano-Vazquez,A.O. Cordoba,E. Llamas,E. San Roman,C. Nisar,N. de la Torre S. Ramos-Vega,M. Gutierrez-Nava,M.D. Cazzonelli,C.I. Pogson,B.J. Leon,P.
2014. An Uncharacterized Apocarotenoid-Derived Signal Generated in zeta-Carotene Desaturase Mutants Regulates Leaf Development and the Expression of Chloroplast and Nuclear Genes in Arabidopsis Plant Cell, 26, 2524-2537.
Lopez-Bucio,J.S. Dubrovsky,J.G. Raya-Gonzalez,J. Ugartechea-Chirino,Y. Lopez-Bucio,J. de Luna-Valdez,L.A. Ramos-Vega,M. Leon,P. Guevara-Garcia,A.A.
2014. Arabidopsis thaliana mitogen-activated protein kinase 6 is involved in seed formation and modulation of primary and lateral root development Journal of Experimental Botany, 65, 169-183.
Gregorio,J. Hernandez-Bernal,A.F. Cordoba,E. Leon,P.
2014. Characterization of evolutionary conserved motifs involved in activity and regulation of the ABA-INSENSITIVE (ABI) 4 transcription factor Molecular Plant, 7, 422-436.
Leon,P. Gregorio,J. Cordoba,E.
2013. ABI4 and its role in chloroplast retrograde communication Frontiers in Plant Science, 3, 304.
Porta,H. Jimenez,G. Cordoba,E. Leon,P. Soberon,M. Bravo,A.
2011. Tobacco plants expressing the Cry1AbMod toxin suppress tolerance to Cry1Ab toxin of Manduca sexta cadherin-silenced larvae Insect Biochemistry and Molecular Biology, 41, 513-519.
Cordoba,E. Porta,H. Arroyo,A. San Roman,C. Medina,L. Rodriguez-Concepcion,M. Leon,P.
2011. Functional characterization of the three genes encoding 1-deoxy-D-xylulose 5-phosphate synthase in maize Journal of Experimental Botany, 62, 2023-2038.
Padilla-Chacon,D. Cordoba,E. Olivera,T. Sanchez,S. Coello,P. Leon,P. Tiessen,A. Martinez-Barajas,E.
2010. Heterologous expression of yeast Hxt2 in Arabidopsis thaliana alters sugar uptake, carbon metabolism and gene expression leading to glucose tolerance of germinating seedlings Plant Molecular Biology, 72, 631-41.
Cordoba,E. Salmi,M. Leon,P.
2009. Unravelling the regulatory mechanisms that modulate the MEP pathway in higher plants Journal of Experimental Botany, 60, 2933-2943.
Bossi,F. Cordoba,E. Dupre,P. Mendoza,M.S. Roman,C.S. Leon,P.
2009. The Arabidopsis ABA-INSENSITIVE (ABI) 4 factor acts as a central transcription activator of the expression of its own gene, and for the induction of ABI5 and SBE2.2 genes during sugar signaling Plant Journal, 59, 359-374.
Phillips,M.A. Leon,P. Boronat,A. Rodriguez-Concepcion,M.
2008. The plastidial MEP pathway: unified nomenclature and resources Trends in Plant Science, 13, 619-623.
Chateigner-Boutin,A.L. Ramos-Vega,M. Guevara-Garcia,A. Andres,C. de la Luz Gutierrez-Nava Cantero,A. Delannoy,E. Jimenez,L.F. Lurin,C. Small,I. Leon,P.
2008. CLB19, a pentatricopeptide repeat protein required for editing of rpoA and clpP chloroplast transcripts Plant Journal, 56, 590-602.
Sauret-Gueto,S. Botella-Pavia,P. Flores-Perez,U. Martinez-Garcia,J.F. San Roman,C. Leon,P. Boronat,A. Rodriguez-Concepcion,M.
2006. Plastid cues post-transcriptionally regulate the accumulation of key enzymes of the methylerythritol phosphate pathway in Arabidopsis Plant Physiology, 141, 75-84.
Juarez-Diaz,J.A. McClure,B. Vazquez-Santana,S. Guevara-Garcia,A. Leon-Mejia,P. Marquez-Guzman,J. Cruz-Garcia,F.
2006. A novel thioredoxin h is secreted in nicotiana alata and reduces S-RNase in vitro Journal of Biological Chemistry, 281, 3418-3424.
Acevedo-Hernandez,G.J. Leon,P. Herrera-Estrella,L.R.
2005. Sugar and ABA responsiveness of a minimal RBCS light-responsive unit is mediated by direct binding of ABI4 Plant Journal, 43, 506-519.
Guevara-Garcia,A. San Roman,C. Arroyo,A. Cortes,M.E. Gutierrez-Nava,M.D. Leon,P.
2005. Characterization of the Arabidopsis clb6 Mutant Illustrates the Importance of Posttranscriptional Regulation of the Methyl-D-Erythritol 4-Phosphate Pathway Plant Cell, 17, 628-643.
Ayala-Ochoa,A. Vargas-Suarez,M. Loza-Tavera,H. Leon,P. Jimenez-Garcia,L.F. Sanchez-De-Jimenez,E.
2004. In maize, two distinct ribulose 1,5-bisphosphate carboxylase/ oxygenase activase transcripts have different day/night patterns of expression Biochimie, 86, 439-449.
Gutierrez-Nava,M.M. Gillmor,C.S. Jimenez,L.F. Guevara-Garcia,A. Leon,P.
2004. Chloroplast biogenesis genes act cell and noncell autonomously in early chloroplast development Plant Physiology, 135, 471-482.
Arroyo,A. Bossi,F. Finkelstein,R.R. Leon,P.
2003. Three genes that affect sugar sensing (abscisic Acid insensitive 4, abscisic Acid insensitive 5, and constitutive triple response 1) are differentially regulated by glucose in Arabidopsis Plant Physiology, 133, 231-242.
Leon,P. Sheen,J.
2003. Sugar and hormone connections Trends in Plant Science, 8, 110-116.
Cheng,W.H. Endo,A. Zhou,L. Penney,J. Chen,H.C. Arroyo,A. Leon,P. Nambara,E. Asami,T. Seo,M. Koshiba,T. Sheen,J.
2002. A Unique Short-Chain Dehydrogenase/Reductase in Arabidopsis Glucose Signaling and Abscisic Acid Biosynthesis and Functions Plant Cell, 14, 2723-2743.
Estevez,J.M. Cantero,A. Reindl,A. Reichler,S. Leon,P.
2001. 1-deoxy-D-xylulose-5-phosphate synthase, a limiting enzyme for plastidic isoprenoid biosynthesis in plants Journal of Biological Chemistry, 276, 22901-22909.
Campos,F. Garcia-Gomez,B.I. Solorzano,R.M. Salazar,E. Estevez,J. Leon,P. Alvarez-Buylla,E.R. Covarrubias,A.A.
2001. A cDNA for nuclear-encoded chloroplast translational initiation factor 2 from a higher plant is able to complement an infB Escherichia coli null mutant Journal of Biological Chemistry, 276, 28388-28394.
Arenas-Huertero,F. Arroyo,A. Zhou,L. Sheen,J. Leon,P.
2000. Analysis of Arabidopsis glucose insensitive mutants, gin5 and gin6, reveals a central role of the plant hormone ABA in the regulation of plant vegetative development by sugar Genes and Development, 14, 2085-2096.
Estevez,J.M. Cantero,A. Romero,C. Kawaide,H. Jimenez,L.F. Kuzuyama,T. Seto,H. Kamiya,Y. Leon,P.
2000. Analysis of the expression of CLA1, a gene that encodes the 1- deoxyxylulose 5-phosphate synthase of the 2-C-methyl-D- erythritol-4-phosphate pathway in Arabidopsis Plant Physiology, 124, 95-103.
Gutierrez-Nava,M.L. Warren,C.A. Leon,P. Walbot,V.
1998. Transcriptionally active MuDR, the regulatory element of the mutator transposable element family of Zea mays, is present in some accessions of the Mexican land race Zapalote chico Genetics, 149, 329-346.
Leon,P. Arroyo,A. Mackenzie,S.
1998. Nuclear control of plastid and mitochondrial development in higher plants Annual Review Of Plant Physiology And Plant Molecular Biology, 49, 453-480.
Jang,J.C. Leon,P. Zhou,L. Sheen,J.
1997. Hexokinase as a sugar sensor in higher plants Plant Cell, 9, 5-19 * .
Mandel,M.A. Feldmann,K.A. Herrera-Estrella,L. Rocha-Sosa,M. Leon,P.
1996. CLA1, a novel gene required for chloroplast development, is highly conserved in evolution Plant Journal, 9, 649-658.
Leon,P. O'Brien-Vedder,C. Walbot,V.
1992. Expression of ORF1 of the linear 2.3 kb plasmid of maize mitochondria: product localization and similarities to the 130 kDa protein encoded by the S2 episome Curr.Genet., 22, 61-67 * .
Leon,P. Planckaert,F. Walbot,V.
1991. Transient gene expression in protoplasts of Phaseolus vulgaris isolated from a cell suspension culture. Plant Physiology, 95, 968-972 * .
Mulligan,R.M. Leon,P. Walbot,V.
1991. Transcriptional and posttranscriptional regulation of maize mitochondrial gene expression Molecular and Cellular Biology, 11, 533-543 * .
Mulligan,R.M. Leon,P. Calvin,N. Walbot,V.
1989. Introduction of DNA into maize and rice mitochondria by electroporation..Maydica, 34, 207-216 * .
Leon,P. Walbot,V. Bedinger,P.
1989. Molecular analysis of the linear 2.3 kb plasmid of maize mitochondria: apparent capture of tRNA genes Nucleic Acids Research, 17, 4089-4099 * .
Leon,P. Alvarez,G. Diaz de Leon,F. Gomez-Eichelmann,M.C.
1988. Effect of DNA supercoiling and catabolite repression on the expression of the tetA genes in Escherichia coli Canadian Journal of Microbiology, 34, 839-842 * .
Bedinger,P. De Hostos,E.L. Leon,P. Walbot,V.
1986. Cloning and characterization of a linear 2.3 kb mitochondrial plasmid of maize. Molecular and General Genetics, 205, 206-212 * .
Leon,P. Romero,D. Garciarrubio,A. Bastarrachea,F. Covarrubias,A.A.
1985. Glutamine synthetase-constitutive mutation affecting the glnALG upstream promoter of Escherichia coli Journal of Bacteriology, 164, 1032-1038.
Libros y capítulos recientes Leon,P. 2018. How Chloroplasts-derived signals influence leaf developmental fate; the voice of the slave en: Sanchez-Sorondo,M. Cell Biology and Genetics. Workshop 23-24 October 2017 Casina Pio IV, Vatican City. Vatican City. Libreria Editrice Vaticana. pags. 122-131
de Luna-Valdez,L.A. Leon-Mejia,P. Encarnacion-Guevara,S. Guevara-Garcia,A.A. 2015. Chloroplast omics en: Davies,D.E. PlantOmics: The omics of plant science. New Delhi. Springer India. pags. 533-558
Leon,P. Cordoba,E. 2013. Understanding the Mechanisms that Modulate the MEP Pathway in Higher Plants en: Rohmer,M. Isoprenoid Synthesis in Plants and Microorganisms. Springer New York. pags. 457-464
Leon,P. Guevara-Garcia,A. 2008. El cloroplasto: un organelo clave en la vida y en el aprovechamiento de las plantas en: *agustin Una ventana al quehacer científico. Instituto de Biotecnología de la UNAM 25 aniversario, cap 20. Mexico, D.F.. UNAM. pags. 215-230
Leon,P. 2003. El cloroplasto en: Merchant-Larios,H. Biología celular y molecular. Mexico,D.F.. Prentice Hall. pags. 315-337
Herrera-Estrella,L. Leon,P. Olsson,O. Teeri,T.H. 1994. Reporter genes for plants en: Schilperoort,R.A. Plant molecular biology manual. Dordrecht. Kluwer Academic Publishers. pags. 1-32
Sheen,J. Huang,H. Schaffner,A.R. Leon,P. Jang,J.C. 1992. Sugars, Fatty Acids, and Photosynthetic gene expression en: Murata,N. Research in photosynthesis : proceedings of the IXth International Congress on Photosynthesis, Nagoya, Japan, August 30-September 4,. Dordrecht, Boston. Kluwer Academic. pags. 753-760 *
Otras Publicaciones Leon,P. Guevara-Garcia,A.
2007. La síntesis de isoprenoides a traves de la vía mep; un nuevo blanco de manipulación para la salud y el beneficio humano Mensaje Bioquimico, 31, 77-91.
Patentes A. Reindl, P. M. Leon, P. J. M. Esteves, G. M. A. Cantero, M. Ebneth y K. Herbers 2003 DNA sequence coding for a 1-deoxy-d-xylulose-5-phosphate synthase and the overproduction thereof in plant.
A. Reindl, P. M. Leon, P. J. M. Esteves, G. M. A. Cantero, M. Ebneth y K. Herbers 2000 DNA sequence coding for a 1-deoxy-d-xylulose-5-phosphate synthase and the overproduction thereof in plant.
Le—n, P J. M. Esteves-Palmas M.A. Cantero-Garc’a , y A. Reindl. 1998 1-deoxy-D-xylulose-5-phosphate synthase in the connection with vitamin E and carotenoid overproduction in plants.Basf Aktiengesellschaft Alemania.
* Indica publicación con otra institución de adscripción
Líder Académico »»