Dr. Lourival Domingos Possani Postay Departamento de Medicina Molecular y Bioprocesos
Teléfonos Oficina +52 (777) 329-1647desde el D.F. 562-27647 red UNAM 27647 |
- Licenciatura: Historia Natural, Fac. de Filosofía de la Universidad Federal de Río Grande do Sul, Brasil (1966)
- Doctorado: en Biofísica, Faculte des Sciences D'Orsay-Universite de París, Francia (octubre 1968-marzo 1970)
- Mencion honorífica en examen de Doctorado (1970)
- Estancia de investigacion en la Universidad Rockefeller, New York, E.U.A. (julio 1971-septiembre 1973)
Premio Redi International Society on Toxinology (2006)
Investigador emérito UNAM (2005)
Doctor Honoris Causa Universidad de Debrecen, Hungría (2005)
Miembro de la Academia de Ciencias de America Latina (1999)
Premio Nacional de Investigación Básica Fundación Glaxo-Wellcome (1998)
Howard Hughes Medical Institute International Research Scholar 1997-2001 (1997)
Premio Nacional de Ciencias y Artes Gobierno de la República (1995)
Premio de Investigacion Medica Dr. Jorge Rosenkran (1994)
Premio Universidad Nacional en el área de Ciencias Naturales UNAM (1993)
Howard Hughes Medical Institute International Research Scholar 1991-1996 (1991)
Schwartz,E.F. Bartok,A. Schwartz,C.A. Papp,F. Gomez-Lagunas,F. Panyi,G. Possani,L.D.
2013. OcyKTx2, a new K-channel toxin characterized from the venom of the scorpion Opisthacanthus cayaporum Peptides, May 15 [Epub ahead of print], .
Bernaldez,J. Roman-Gonzalez,S.A. Martinez,O. Jimenez,S. Vivas,O. Arenas,I. Corzo,G. Arreguin,R. Garcia,D.E. Possani,L.D. Licea,A.
2013. A Conus regularis Conotoxin with a Novel Eight-Cysteine Framework Inhibits CaV2.2 Channels and Displays an Anti-Nociceptive Activity Mar.Drugs, 11, 1188-1202.
Mourao,C.B. Heghinian,M.D. Barbosa,E.A. Mari,F. Bloch,J.C. Restano-Cassulini,R. Possani,L.D. Schwartz,E.F.
2013. Characterization of a novel peptide toxin from Acanthoscurria paulensis spider venom: a distinct cysteine assignment into the HWTX-II family Biochemistry, 52, 2440-2452.
Sanchez-Vasquez,L. Silva-Sanchez,J. Jimenez-Vargas,J.M. Rodriguez-Romero,A. Munoz-Garay,C. Rodriguez,M.C. Gurrola,G.B. Possani,L.D.
2013. Enhanced antimicrobial activity of novel synthetic peptides derived from vejovine and hadrurin Biochimica et Biophysica Acta (BBA), 1830, 3427-3436.
Caliskan,F. Quintero-Hernandez,V. Restano-Cassulini,R. Coronas-Valderrama,F.I. Corzo,G. Possani,L.D.
2013. Molecular cloning and biochemical characterization of the first Na+-channel alpha-type toxin peptide (Acra4) from Androctonus crassicauda scorpion venom Biochimie, 95, 1216-1222.
Aguilar,M.B. Ortiz,E. Kaas,Q. Lopez-Vera,E. Becerril,B. Possani,L.D. de la Cotera,E.P.
2013. Precursor De13.1 from Conus delessertii defines the novel G gene superfamily Peptides, 41, 17-20.
Pedraza-Escalona,M. Possani,L.D.
2013. Scorpion beta-toxins and voltage-gated sodium channels: interactions and effects Front Biosci, 18, 572-587.
Luna-Ramirez,K. Quintero-Hernandez,V. Vargas-Jaimes,L. Batista,C.V. Winkel,K. Possani,L.D.
2013. Characterization of the venom from the Australian scorpion Urodacus yaschenkoi: molecular mass analysis of components, cDNA sequences and peptides with antimicrobial activity Toxicon, 63, 44-54.
Garcia,F. Villegas,E. Espino-Solis,G.P. Rodriguez,A. Paniagua-Solis,J.F. Sandoval-Lopez,G. Possani,L.D. Corzo,G.
2013.
Antimicrobial peptides from arachnid venoms and their microbicidal activity in the presence of commercial antibiotics J Antibiot.(Tokyo), 66, 3-10.
Wang,X. Jimenez-Vargas,J.M. Xu,C. Possani,L.D. Zhu,S.
2012. Positive selection-guided mutational analysis revealing two key functional sites of scorpion ERG K(+) channel toxins Biochem Biophys Res Commun, 429, 111-116.
Clement,H. Olvera,A. Rodriguez,M. Zamudio,F. Palomares,L.A. Possani,L.D. Odell,G.V. Alagon,A. Sanchez-Lopez,R.
2012. Identification, cDNA cloning and heterologous expression of a hyaluronidase from the tarantula Brachypelma vagans venom Toxicon, 60, 1223-1227.
Clement,H. Costa de Oliveira,V. Zamudio,F.Z. Lago,N.R. Valdez-Cruz,N.A. Valle,M.B. Alagon,A.C. Possani,L.D. de Roodt,A.R.
2012. Isolation, amino acid sequence and biological characterization of an "aspartic-49" phospholipase A(2) from Bothrops (Rhinocerophis) ammodytoides Venom Toxicon, 60, 1314-1323.
Rendon-Anaya,M. Delaye,L. Possani,L.D. Herrera-Estrella,A.
2012. Global Transcriptome Analysis of the Scorpion Centruroides noxius: New Toxin Families and Evolutionary Insights from an Ancestral Scorpion Species PLoS ONE, 7, e43331.
Rodriguez-Rodriguez,E.R. Ledezma-Candanoza,L.M. Contreras-Ferrat,L.G. Olamendi-Portugal,T. Possani,L.D. Becerril,B. Riano-Umbarila,L.
2012. A Single Mutation in Framework 2 of the Heavy Variable Domain Improves the Properties of a Diabody and a Related Single-Chain Antibody J Mol Biol, 423, 337-350.
Caliskan,F. Garcia,B.I. Coronas,F.I. Restano-Cassulini,R. Korkmaz,F. Sahin,Y. Corzo,G. Possani,L.D.
2012. Purification and cDNA cloning of a novel neurotoxic peptide (Acra3) from the scorpion Androctonus crassicauda Peptides, 37, 106-112.
Varga,Z. Gurrola-Briones,G. Papp,F. Rodriguez de la Vega RC Pedraza-Alva,G. Tajhya,R.B. Gaspar,R. Cardenas,L. Rosenstein,Y. Beeton,C. Possani,L.D. Panyi,G.
2012. Vm24, a Natural Immunosuppressant Peptide Potently and Selectively Blocks Kv1.3 Potassium Channels of Human T Cells Mol Pharmacol., 82, 372-382.
Gurrola,G.B. Hernandez-Lopez,R.A. Rodriguez de la Vega RC Varga,Z. Batista,C.V. Salas-Castillo,S.P. Panyi,G. del Rio-Portilla,F. Possani,L.D.
2012. Structure, function and chemical synthesis of Vaejovis mexicanus peptide 24: a novel potent blocker of Kv1.3 potassium channels of human T lymphocytes Biochemistry, 51, 4049-4061.
Jimenez-Vargas,J.M. Restano-Cassulini,R. Possani,L.D.
2012. Toxin modulators and blockers of hERG K(+) channels Toxicon, 60, 492-501.
Jimenez-Vargas,J.M. Restano-Cassulini,R. Possani,L.D.
2012. Interacting sites of scorpion toxin ErgTx1 with hERG1 K(+) channels Toxicon, 59, 633-641.
Guerrero-Vargas,J.A. Mourao,C.B. Quintero-Hernandez,V. Possani,L.D. Schwartz,E.F.
2012. Identification and Phylogenetic Analysis of Tityus pachyurus and Tityus obscurus Novel Putative Na-Channel Scorpion Toxins PLoS ONE, 7, e30478.
Ramirez-Carreto,S. Quintero-Hernandez,V. Jimenez-Vargas,J.M. Corzo,G. Possani,L.D. Becerril,B. Ortiz,E.
2012. Gene cloning and functional characterization of four novel antimicrobial-like peptides from scorpions of the family Vaejovidae Peptides, 34, 290-295.
Quintero-Hernandez,V. Del Pozo-Yauner,L. Pedraza-Escalona,M. Juarez-Gonzalez,V.R. Alcantara-Recillas,I. Possani,L.D. Becerril,B.
2012. Evaluation of three different formats of a neutralizing single chain human antibody against toxin Cn2: Neutralization capacity versus thermodynamic stability Immunol Lett, 143, 152-160.
Saucedo,A.L. Del Rio F. Picco,C. Estrada,G. Prestipino,G. Possani,L.D. Delepierre,M. Corzo,G.
2012. Solution structure of native and recombinant expressed toxin CssII from the venom of the scorpion suffusus, and their effects on Nav1.5 Sodium channels Biochimica et Biophysica Acta (BBA), 1824, 478-487.
Caliskan,F. Quintero-Hernandez,V. Restano-Cassulini,R. Batista,C.V.F. Zamudio,F.Z. Coronas,F.I. Possani,L.D.
2012. Turkish scorpion Buthacus macrocentrus: General characterization of the venom and description of Bu1, a potent mammalian Na+-channel a-toxin Toxicon, 59, 408-415.
Saucedo,A.L. Flores-Solis,D. Rodriguez de la Vega RC Ramirez-Cordero,B. Hernandez-Lopez,R. Cano-Sanchez,P. Noriega-Navarro,R. Garcia-Valdes,J. Coronas-Valderrama,F. de,R.A. Brieba,L.G. Possani,L.D. del Rio-Portilla,F.
2012. New tricks of an old pattern: structural versatility of scorpion toxins with common cysteine spacing J Biol Chem, 287, 12321-12330.
Schiavon,E. Pedraza-Escalona,M. Gurrola,G.B. Olamendi-Portugal,T. Corzo,G. Wanke,E. Possani,L.D.
2012. Negative-shift activation, current reduction and resurgent currents induced by beta-toxins from Centruroides scorpions in sodium channels Toxicon, 59, 283-293.
Quintero-Hernandez,V. Ortiz,E. Rendon,M.R. Schwartz,E.F. Becerril,B. Corzo,G. Possani,L.D.
2011. Scorpion and spider venom peptides: Gene cloning and peptide expression Toxicon, 58, 644-663.
Camargos,T.S. Restano-Cassulini,R. Possani,L.D. Peigneur,S. Tytgat,J. Schwartz,C.A. de Freitas,S.M. Schwartz,E.F.
2011. The new kappa-KTx 2.5 from the scorpion Opisthacanthus cayaporum Peptides, 32, 1509-1517.
Amaro,I. Riano-Umbarila,L. Becerril,B. Possani,L.D.
2011. Isolation and characterization of a human antibody fragment specific for Ts1 toxin from Tityus serrulatus scorpion Immunol Lett, 139, 73-79.
Garcia-Gomez,B.I. Coronas,F.I. Restano-Cassulini,R. Rodriguez,R.R. Possani,L.D.
2011. Biochemical and molecular characterization of the venom from the Cuban scorpion Rhopalurus junceus Toxicon, 58, 18-27.
Canul-Tec,J.C. Riano-Umbarila,L. Rudino-Pinera,E. Becerril,B. Possani,L.D. Torres-Larios,A.
2011. Structural basis of neutralization of the major toxic component from the scorpion centruroides noxius hoffmann by a human-derived single chain antibody fragment J Biol Chem, 286, 20892-20900.
Espino-Solis,G.P. Estrada,G. Olamendi-Portugal,T. Villegas,E. Zamudio,F. Cestele,S. Possani,L.D. Corzo,G.
2011. Isolation and molecular cloning of beta-neurotoxins from the venom of the scorpion Centruroides suffusus suffusus Toxicon, 57, 739-746.
Riano-Umbarila,L. Contreras-Ferrat,G. Olamendi-Portugal,T. Morelos-Juarez,C. Corzo,G. Possani,L.D. Becerril,B.
2011. Exploiting cross-reactivity to neutralize two different scorpion venoms with one single-chain antibody fragment J Biol Chem, 286, 6143-6151.
Estrada,G. Restano-Cassulini,R. Ortiz,E. Possani,L.D. Corzo,G.
2011. Addition of positive charges at the C-terminal peptide region of CssII; a mammalian scorpion peptide toxin; improves its affinity for sodium channels Nav1.6 Peptides, 32, 75-79 (Correction vol 32 p.1096).
Hernandez-Aponte,C.A. Silva-Sanchez,J. Quintero-Hernandez,V. Rodriguez-Romero,A. Balderas,C. Possani,L.D. Gurrola,G.B.
2011. Vejovine, a new antibiotic from the scorpion venom of Vaejovis mexicanus Toxicon, 57, 84-92.
Jimenez-Vargas,J.M. Restano-Cassulini,R. Quintero-Hernandez,V. Gurrola,G.B. Possani,L.D.
2011. Recombinant expression of the toxic peptide ErgTx1 and role of Met35 on its stability and function Peptides, 32, 560-567.
Corrales-Garcia,L.L. Possani,L.D. Corzo,G.
2011. Expression systems of human beta-defensins: vectors, purification and biological activities Amino Acids, 40, 5-13.
Rodriguez,A. Villegas,E. Satake,H. Possani,L.D. Corzo,G.
2011.
Amino acid substitutions in an alpha-helical antimicrobial arachnid peptide affect its chemical properties and biological activity towards pathogenic bacteria but improves its therapeutic index Amino Acids, 40, 61-68.
Gurrola,G.B. Capes,E.M. Zamudio,F.Z. Possani,L.D. Valdivia,H.H.
2010. Imperatoxin A, a Cell-Penetrating Peptide from Scorpion Venom, as a Probe of Ca-Release Channels/Ryanodine Receptors Pharmaceuticals.(Basel), 3, 1093-1107.
Vandendriessche,T. Olamendi-Portugal,T. Zamudio,F.Z. Possani,L.D. Tytgat,J.
2010. Isolation and characterization of two novel scorpion toxins: the alpha-toxin-like CeII8, specific for Na(v)1.7 channels and the classical anti-mammalian CeII9, specific for Na(v)1.4 channels Toxicon, 56, 613-623.
Zhu,S. Gao,B. Aumelas,A. Rodriguez,M.D. Lanz-Mendoza,H. Peigneur,S. Diego-Garcia,E. Martin-Eauclaire,M.F. Tytgat,J. Possani,L.D.
2010.
MeuTXKbeta1, a scorpion venom-derived two-domain potassium channel toxin-like peptide with cytolytic activity Biochimica et Biophysica Acta (BBA) Proteins & Proteomics, 1804, 872-883.
Redaelli,E. Restano-Cassulini,R. Fuentes-Silva D. Clement,H. Schiavon,E. Zamudio,F.Z. Odell,G. Arcangeli,A. Clare,J.J. Alagon,A. Rodriguez de la Vega RC Possani,L.D. Wanke,E.
2010.
Target promiscuity and heterogeneous effects of tarantula venom peptides affecting Na+ and K+ ion channels J Biol Chem, 285, 4130-4142 (Correction vol 285 (17) pp 13314-13314).
Rodriguez de la Vega RC Schwartz,E.F. Possani,L.D.
2010.
Mining on scorpion venom biodiversity Toxicon, 56, 1155-1161.
de Roodt,A.R. Coronas,F.I. Lago,N. Gonzalez,M.E. Laskowicz,R.D. Beltramino,J.C. Saavedra,S. Lopez,R.A. Reati,G. Vucharchuk,M.G. Bazan,E. Varni,L. Salomon,O.D. Possani,L.D.
2010.
General biochemical and immunological characterization of the venom from the scorpion Tityus trivittatus of Argentina Toxicon, 55, 307-319.
Espino-Solis,G.P. Calderon-Amador,J. Calderon-Aranda,E.S. Licea,A.F. Donis-Maturano,L. Flores-Romo,L. Possani,L.D.
2009.
Rational design of synthetic peptides to generate antibodies that recognize in situ CD11c+ putative dendritic cells in horse lymph nodes Veterinary Immunology and Immunopathology, 132, 181-190.
Corzo,G. Prochnicka-Chalufour,A. Garcia,B.I. Possani,L.D. Delepierre,M.
2009.
Solution structure of Cn5, a crustacean toxin found in the venom of the scorpions Centruroides noxius and Centruroides suffusus suffusus Biochimica et Biophysica Acta-Proteins and Proteomics, 1794, 1591-1598.
Hernandez-Salgado,K. Estrada,G. Olvera,A. Coronas,F.I. Possani,L.D. Corzo,G.
2009.
Heterologous expressed toxic and non-toxic peptide variants of toxin CssII are capable to produce neutralizing antibodies against the venom of the scorpion Centruroides suffusus suffusus Immunol Lett, 125, 93-99.
Papp,F. Batista,C.V. Varga,Z. Herceg,M. Roman-Gonzalez,S.A. Gaspar,R. Possani,L.D. Panyi,G.
2009.
Tst26, a novel peptide blocker of Kv1.2 and Kv1.3 channels from the venom of Tityus stigmurus Toxicon, 54, 379-389.
D'Suze,G. Schwartz,E.F. Garcia,B.I. Sevcik,C. Possani,L.D.
2009.
Molecular cloning and nucleotide sequence analysis of genes from a cDNA library of the scorpion Tityus discrepans Biochimie, 91, 1010-1019.
Kauferstein,S. Kendel,Y. Nicke,A. Coronas,F.I. Possani,L.D. Favreau,P. Krizaj,I. Wunder,C. Kauert,G. Mebs,D.
2009.
New conopeptides of the D-superfamily selectively inhibiting neuronal nicotinic acetylcholine receptors Toxicon, 54, 295-301.
Schwartz,E.F. Capes,E.M. Diego-Garcia,E. Zamudio,F.Z. Fuentes,O. Possani,L.D. Valdivia,H.H.
2009.
Characterization of hadrucalcin, a peptide from Hadrurus gertschi scorpion venom with pharmacological activity on ryanodine receptors Br.J Pharmacol., 157, 392-403.
Silva,E.C. Camargos,T.S. Maranhao,A.Q. Silva-Pereira,I. Silva,L.P. Possani,L.D. Schwartz,E.F.
2009.
Cloning and characterization of cDNA sequences encoding for new venom peptides of the Brazilian scorpion Opisthacanthus cayaporum Toxicon, 54, 252-261.
Corzo,G. Bernard,C. Clement,H. Villegas,E. Bosmans,F. Tytgat,J. Possani,L.D. Darbon,H. Alagon,A.
2009.
Insecticidal peptides from the theraposid spider Brachypelma albiceps: A NMR-based model of Ba2 Biochimica et Biophysica Acta (BBA), 1794, 1190-1196.
Gonzalez-Morales,L. Diego-Garcia,E. Segovia,L. Gutierrez,M.C. Possani,L.D.
2009.
Venom from the centipede Scolopendra viridis Say: purification, gene cloning and phylogenetic analysis of a phospholipase A2 Toxicon, 54, 8-15.
Prestipino,G. Corzo,G. Romeo,S. Murgia,A.R. Zanardi,I. Gurrola,G. Possani,L.D.
2009.
Scorpion toxins that block transient currents (IA) of rat cerebellum granular cells Toxicology Letters, 187, 1-9.
Espino-Solis,G.P. Riaño-Umbarila,L. Becerril,B. Possani,L.D.
2009.
Antidotes against venomous animals: State of the art and prospectives Journal of Proteomics, 72, 183-199.
Garcia-Gomez,B.I. Olamendi-Portugal,T.C. Paniagua,J. van der Walt,J. Dyason,K. Possani,L.D.
2009.
Heterologous expression of a gene that codes for Pg8, a scorpion toxin of Parabuthus granulatus, capable of generating protecting antibodies in mice Toxicon, 53, 770-778.
Rodriguez-de-la-Vega,R. Possani,L.D. 2013. Scorpion Peptides en: Kastin,A.J. Handbook of Biologically Active Peptides, second edition. Elsevier. in press
Rodriguez de la Vega,R.C. Corzo,G. Possani,L.D. 2013. Scorpion Venoms as a Platform for Drug Development en: Guccione,S. Venoms to Drugs: Venom as a Source for the Development of Human Therapeutics. Cambridge. Royal Society of Chemistry. in press
Possani,L.D. Gurrola,G.B. Schwartz,E. Restano,R. 2011. Bioquimica y biologia molecular de los venenos de escorpiones de importancia medica en el continente americano en: Paniagua Solis,J.F. Emergencias por Animales Ponzonosos en las Americas. Mexico. Instituto Bioclon. pags. 147-180
Valdez-Cruz,N.A. Conde,R. Zamudio,F. Possani,L.D. 2011. Anticoagulants from scorpion venoms en: Marklan,F.S. Toxins and Hemostasis: From Bench to Bedside. Springer. pags. 255-266
Rodriguez-de-la-Vega,R. Barraza,R. Restano,R. Possani,L.D. 2009. Toxins active on Herg channel: structure and function, en: de Lima M.E. Animal toxins: State of the Art. Perspectives in Health and Biotechnology. Belo Horizonte. Universidad de Minas Gerais. pags. 193-204
Corzo G. , Garcia F. , Possani L.D. , Villegas E. 2011 Uso de un peptido antibiotico proveniente del veneno del alacran Centruroides suffusus suffusus y sus composiciones farmaceuticas obtenidas con antibioticos comerciales.UNAM México. (en trámite)
A. Alagón C., L. D. Possani P, G. Gurrola B., E. V. Grishin, A. V. Lipkin & K. E. Volynski 2010 Inmunógeno, anti-veneno y vacuna contra el veneno de la araña viuda negra.UNAM Mexico.
L. D. Possani P., G. Gurrola-Briones, S. P. Salas-Castillo, C. V. Ferreira B., Z. S. Varga, G. Panyi y R. Gaspar 2009 Vm23 and Vm24, two scorpion peptides that block human-T-lymphocyte potassium channels (sub-type Kv1.3) with high selectivity and decrease the in vivo DTH-responses in rats.UNAM Europa 07734817.5,Estados Unidos 12/599,978, China 200780053305.7, Canadá CA 2686216, Australia 2007353147, Israel 202113, Euroasia 200901530, Corea 10-2009-7026000,Brasil (pendiente), Cuba 2009-0194, Japón (pendiente), India 7396/DELNP/2009, México MX/a/2009/01209, Israel 202113, Corea 10-2009-7026000, y Singapur 200907395-8. (en trámite)
Georgina Gurrola Briones, Cynthia Annabel Hernández Aponte, Jesús Silva Sánchez, y Lourival Domingos Possani Postay 2009 Vejovina - Un péptido antibiótico.UNAM México. (en trámite)
L. Riaño U., B. Becerril L. y L. Possani P 2009 Variantes de anticuerpos humanos que reconocen específicamente a la toxina CN2 y al veneno del alacrán Centruroides noxius.UNAM México.
L. D. Possani P., G. Gurrola-Briones, S. P. Salas-Castillo, C. V. Ferreira B., Z. S. Varga, G. Panyi y R. Gaspar 2009 Vm23 and Vm24, two scorpion peptides that block human-T-lymphocyte potassium channels (sub-type Kv1.3) with high selectivity and decrease the in vivo DTH-responses in rats.UNAM Sudáfrica.
L. Riaño, B. Becerril y L.D. Possani 2008 Human antibody variants that specifically recognize the toxin CN2 from Centruroides noxius scorpion venom.UNAM Estados Unidos.
M. Corona, M. C. García, N. A. Valdez, G. Gurrola, B. Becerril y L.D. Possani 2008 Recombinant Immunogens for the Generation of Antivenoms to the Venom of Scorpions of the Genus Centruroides.UNAM Estados Unidos.
B. I. García-Gómez, T. C. Olamendi-Gómez y L. D. Possani P 2008 Inmunógenos recombinantes para la producción de antivenenos contra el veneno de alacranes del género Parabuthus.UNAM México. (en trámite)
G.A.Corzo-Burguete, G. Estrada-Tapia, K. Hernández-Salgado, B. I. García-Gómez y L. D. Possani P 2008 Inmunógenos recombinantes para la producción de antivenenos contra el veneno de alacranes del género Centruroides.UNAM México. (en trámite)
Corzo, G., Estrada. G. , Hernandez, K. , Garcia B.I. , Possani. L.D 2008 Variantes recombinantes de una toxina del veneno del alacrán Centruroides sufussus sufussus para la producción de antivenenos contra el veneno de alacranes del género Centruroides.UNAM México.
L.D. Possani, F. Zamudio y A. Torres 2007 Hadrurina - Un péptido antibiótico.UNAM México.
L. D. Possani P., G. Gurrola-Briones, S. P. Salas-Castillo, C. V. Ferreira B., Z. S. Varga, G. Panyi y R. Gaspar 2007 Vm23 and Vm24, two scorpion peptides that block human-T-lymphocyte potassium channels (sub-type Kv1.3) with high selectivity and decrease the in vivo DTH-responses in rats.UNAM PCT. (en trámite)
B. Becerril, F. Zamudio, B. Selisko, L.D. Possani, A. Ramírez y M. C. García 2005 Secuencia Primaria y ADNc de toxinas con actividad insecticida de alacranes del género Centruroides (Divisional).UNAM México.
Riaño L. , B. Becerril y L.D. Possani 2005 Human antibody variants that specifically recognize the toxin CN2 from Centruroides noxius scorpionon venom. Estados Unidos. (en trámite)
M. Corona, M. C. García, N. A. Valdez, G. Gurrola, B. Becerril y L. D. Possani 2003 Inmunógenos recombinantes para la generación de antivenenos contra el veneno de alacranes del género Centruroides.UNAM México. (en trámite)
M. Corona, M. C. García, N. A. Valdez, G. Gurrola, B. Becerril y L. D. Possani 2002 Inmunógenos recombinantes para la generación de antivenenos contra el veneno de alacranes del género Centruroides.UNAM Estados Unidos. (en trámite)
B. Becerril, F. Zamudio, B. Selisko, L. D. Possani, A. Ramírez y C. García 2002 Secuencia Primaria y ADNc de toxinas con actividad insecticida de alacranes del género Centruroides.UNAM México.
B. Becerril, F. Zamudio, B. Selisko, L.D. Possani, A. Ramírez y M.C. García 2002 Secuencia Primaria y ADNc de toxinas con actividad insecticida de alacranes del género Centruroides (Divisional).UNAM México.
G. Gurrola, A. Alagón C. L. D. Possani P., E. V. Grishin, A. V. Lipkin y K. E. Volynski 2002 Immunogen, Anti-Venom and Vaccine Against the Venom of the Black Widow Spider.UNAM Estados Unidos, Europa EP00980069.9 y Canadá 2,397,731.
B. Selisko, B. Becerril F. Zamudio, L. D. Possani A. Ramírez y C. García 2001 Primary sequence and cDNA of insecticidally effective toxins from scorpions of the genus Centruroides.UNAM Estados Unidos.
L. D. Possani, B. Becerril y A. F. Licea N 2001 ADNc y fragmento Fab del anticuerpo BCF2 y su utilización en composiciones farmacéuticas neutralizantes de veneno de alacrán.UNAM México.
G. Gurrola B., A. Alagón C., L. D. Possani P., E. V. Grishin, A. V. Lipkin y K. E. Volynski 2000 Inmunógeno, anti-veneno y vacuna contra el veneno de la araña viuda negra.UNAM PCT.
C. Noeske-Jungblut, W.D. Schleuning, A. Alagon, L.D Possani, D.A. Cuevas-Aguirre, P. Donner, B. Haendler y U. Hechler 1999 Thormbin inhibitor from saliva protostomia.Schering Estados Unidos.
A. Alagón C., L. D. Possani P., G. Gurrola B., E. V. Grishin, A. V. Lipkin y K. E. Volynski 1999 Inmunógeno, anti-veneno y vacuna contra el veneno de la araña viuda negra.UNAM-Inst. de QuÍmica Bioorgánica México. (en trámite)
C. Noeske-jungbut, B. Haendler, J.R. kraestzschmar, W.D. Schlenuning, A. Alagon, L.D. possani, yD.A Cuevas-Aguirre 1998 Collagen-induced platelet aggration inhibitor.Schering Estados Unidos.
C. Noeske-jungbut, B. Haendler, J.R. kraestzschmar, W.D. Schlenuning, A. Alagon, L.D. possani, y D.A Cuevas-Aguirre 1998 Collagen-induced platelet aggration inhibitor.Schering Europa.
C. Noeske-jungbut B. Haendler J.R. kraestzschmar W.D. Schlenuning A. Alagon L.D. possani D.A Cuevas-Aguirre 1998 Collagen-induced platelet aggration inhibitor.Schering Europa.
C. Noeske-jungblut W.D. Schelunig A. Alagon L.D. Possani D.A. Cuevas-Aguirre P. Donner B. Haendler y U. Hechler 1997 Clotting inhibitor made from protostomia saliva.Schering Europa.
L.D. Possani, B. Becerril, M. Corona, F. Ingerborg, F. Zamudio, E.S. Calderón, P. Litton y B.M. Martin 1995 Producao de peptideos de escorpioes Tityus serrulatus, Tityus bahiensis e Tityus stigmurus, e respectiva inmunizacao de cavalo, visando a obtencao de soros antiescorpionicos.UNAM-Fundación Butantan Brasil.
L.D. Possani P. G. Gurrola B. M.A.A. Bayón C. M. Sitges B. 1991 Procedimiento, diseÒo y síntesis para la obtención de péptidos sintéticos de estructura (Ax)N-(As)N-As, capaces de formar derivados beta-carbonilos para sustratos fluorogénicos de enzimas hidrolasas.UNAM México. (en trámite)
L D. Possani P. G. Gurrola B. M. A. A. Bayón C y M. Sitges B. 1990 Synthetic Noxiustoxin related peptides.UNAM Estados Unidos.
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