. Instituto de Biotecnologia UNAM

IBT-UNAM : Dr. Roberto Pablo Stock Silberman

Dr. Roberto Pablo Stock Silberman

ex-colaborador y/o ex-alumno
Nivel II del SNI
Líneas de investigación
Teléfonos

- Licenciatura: Bioquímica, Albright College, Reading, Pennsylvania, E.U.A. (1985)
- Maestría: en Microbiología, Universidad Hebrea de Jerusalen, Israel (1988-1990)
- Doctorado: en Bioquímica y Biología Molecular, Universidad de Granada, Espana (1995)
- Premio en Licenciatura en Química Analítica de la American Chemical Society (1985)
- Premio "Golda Meir Fellowship Fund, Universidad Hebrea, Jerusalen (1990)
- Beca para realizar estudios de Doctorado, Instituto de Cooperacion Iberoamericano (1992-1995)

Publicaciones recientes

Thoke,H.S. Tobiesen,A. Brewer,J. Hansen,P.L. Stock,R.P. Olsen,L.F. Bagatolli,L.A. 2015. Tight Coupling of Metabolic Oscillations and Intracellular Water Dynamics in Saccharomyces cerevisiae PLoS ONE, 10, e0117308.

Balde,M.C. Chippaux,J.P. Boiro,M.Y. Stock,R.P. Massougbodji,A. 2013. Use of antivenoms for the treatment of envenomation by Elapidae snakes in Guinea, Sub-Saharan Africa Journal of Venomous Animals and Toxins Including Tropical Diseases, 19, 6.

Balde,M.C. Chippaux,J.P. Boiro,M.Y. Stock,R. Massougbodji,A. 2012. Clinical study of tolerance and effectiveness of a F (ab') 2 polyvalent antienom for African snake bites in Kindia, Guinea. Étude clinique de la tolérance et de l'efficacité d'un sérum anti-ophidien polyvalent F(ab)2 pour l'Afrique à Kindia, Guinée Bulletin de la Societe de Pathologie Exotique, 105, 157-161.

Stock,R.P. Brewer,J. Wagner,K. Ramos-Cerrillo,B. Duelund,L. Jernshoj,K.D. Olsen,L.F. Bagatolli,L.A. 2012. Sphingomyelinase D Activity in Model Membranes: Structural Effects of in situ Generation of Ceramide-1-Phosphate PLoS ONE, 7, e36003.

de Roodt,A.R. Lago,N.R. Stock,R.P. 2012. Myotoxicity and nephrotoxicity by Micrurus venoms in experimental envenomation Toxicon, 59, 356-364.

Chippaux,J.P. Diouf,A. Massougbodji,A. Stock,R.P. Kane,O. Dieye,A.M. Lam,F.A. Mbaye,S.M. Parra,H.J. 2011. [Response to cholera epidemic in Port-au-Prince, Haiti in December 2010 Dakar 25-29 avril 2011] Médecine tropicale: revue du Corps de santé colonial, 71, 431-433.

de Roodt,A.R. Lanari,L.C. Costa de Oliveira,V. Laskowicz,R.D. Stock,R.P. 2011. Neutralization of Bothrops alternatus regional venom pools and individual venoms by antivenom: A systematic comparison Toxicon, 57, 1073-1080.

Archundia,I.G. de Roodt,A.R. Ramos-Cerrillo,B. Chippaux,J.P. Olguin-Perez,L. Alagon,A. Stock,R.P. 2011. Neutralization of Vipera and Macrovipera venoms by two experimental polyvalent antisera: A study of paraspecificity Toxicon, 57, 1049-1056.

Chippaux,J.P. Stock,R.P. Massougbodji,A. 2010. Methodology of clinical studies dealing with the treatment of envenomation Toxicon, 55, 1195-212.

Casasola,A. Ramos-Cerrillo,B. de Roodt,A.R. Saucedo,A.C. Chippaux,J.P. Alagon,A. Stock,R.P. 2009. Paraspecific neutralization of the venom of African species of cobra by an equine antiserum against Naja melanoleuca: A comparative study Toxicon, 53, 602-608.

Ramos-Cerrillo,B. de Roodt,A.R. Chippaux,J.P. Olguin,L. Casasola,A. Guzman,G. Paniagua-Solis,J. Alagon,A. Stock,R.P. 2008. Characterization of a new polyvalent antivenom (Antivipmyn((R)) Africa) against African vipers and elapids Toxicon, 52, 881-888.

Chippaux,J.P. Diedhiou,I. Stock,R. 2007. Study of the action of black stone (also known as snakestone or serpent stone) on experimental envenomation Cahiers Sante, 17, 127-131.

Chippaux,J.P. Massougbodji,A. Stock,R.P. Alagon,A. 2007. Clinical Trial of an F(ab')2 Polyvalent Equine Antivenom for African Snake Bites in Benin American Journal of Tropical Medicine and Hygiene, 77, 538-546.

Dragulev,B. Bao,Y. Ramos-Cerrillo,B. Vazquez,H. Olvera,A. Stock,R.P. Alagon,A. Fox,J.W. 2007. Upregulation of cytokine expression in fibroblasts exposed to Loxosceles sphingomyelinase D: What is the trigger? Journal of Investigative Dermatology, 127, 1267-1268.

Dragulev,B. Bao,Y. Ramos-Cerrillo,B. Vazquez,H. Olvera,A. Stock,R. Algaron,A. Fox,J.W. 2007. Upregulation of IL-6, IL-8, CXCL1, and CXCL2 Dominates Gene Expression in Human Fibroblast Cells Exposed to Loxosceles reclusa Sphingomyelinase D: Insights into Spider Venom Dermonecrosis Journal of Investigative Dermatology, 127, 1264-1266.

Chippaux,J.P. Ramos-Cerrillo,B. Stock,R.P. 2007. Study of the efficacy of the black stone on envenomation by snake bite in the murine model Toxicon, 49, 717-720.

Olvera,A. Ramos-Cerrillo,B. Estevez,J. Clement,H. de Roodt,A. Paniagua-Solis,J. Vazquez,H. Zavaleta,A. Salas-Arruz,M. Stock,R.P. Alagon,A. 2006. North and South American Loxosceles spiders: Development of a polyvalent antivenom with recombinant sphingomyelinases D as antigens Toxicon, 48, 64-74.

Sanchez,R. Saralegui,A. Olivos-Garcia,A. Scapolla,C. Damonte,G. Sanchez-Lopez,R. Alagon,A. Stock,R.P. 2005. Entamoeba histolytica: intracellular distribution of the sec61alpha subunit of the secretory pathway and down-regulation by antisense peptide nucleic acids Experimental Parasitology, 109, 241-251.

Martinez,C. Paredes,R. Stock,R.P. Saralegui,A. Andreu,M. Cabezon,C. Ehrlich,R. Galanti,N. 2005. Cellular organization and appearance of differentiated structures in developing stages of the parasitic platyhelminth Echinococcus granulosus Journal of Cellular Biochemistry, 94, 327-335.

Ramos-Cerrillo,B. Olvera,A. Odell,G.V. Zamudio,F. Paniagua-Solis,J. Alagon,A. Stock,R.P. 2004. Genetic and enzymatic characterization of sphingomyelinase D isoforms from the North American fiddleback spiders Loxosceles boneti and Loxosceles reclusa Toxicon, 44, 507-514 [Correction TOXICON 46 (2): 241-241 AUG 2005].

Stock,R.P. Bialy,H. 2003. The sigmoidal curve of cancer Nature Biotechnology, 21, 13-14.

Scarfi,S. Giovine,M. Pintus,R. Millo,E. Clavarino,E. Pozzolini,M. Sturla,L. Stock,R.P. Benatti,U. Damonte,G. 2003. Selective inhibition of inducible cyclooxygenase-2 expression by antisense peptide nucleic acids in intact murine macrophages Biotechnology and Applied Biochemistry, 38, 61-69.

Cerecedo,D. Stock,R. Gonzalez,S. Reyes,E. Mondragon,R. 2002. Modification of actin, myosin and tubulin distribution during cytoplasmic granule movements associated with platelet adhesion Haematologica, 87, 1165-1176.

Sanchez,R. Alagon,A. Stock,R.P. 2002. Entamoeba histolytica: intracellular distribution of the proteasome Experimental Parasitology, 102, 187-190.

Juarez,P. Sanchez-Lopez,R. Stock,R.P. Olvera,A. Ramos,M.A. Alagon,A. 2001. Characterization of the Ehrab8 gene, a marker of the late stages of the secretory pathway of Entamoeba histolytica Molecular and Biochemical Parasitology, 116, 223-228.

Stock,R.P. Olvera,A. Sanchez,R. Saralegui,A. Scarfi,S. Sanchez-Lopez,R. Ramos,M.A. Boffa,L.C. Benatti,U. Alagon,A. 2001. Inhibition of gene expression in Entamoeba histolytica with antisense peptide nucleic acid oligomers Nature Biotechnology, 19, 231-234.

Sanchez-Lopez,R. Gutierrez,A. Juarez,P. Olvera,A. Olvera,F. Ramos,M.A. Sanchez,R. Saralegui,A. Stock,R.P. Alagon,A. 2000. Molecular genetics of the secretory pathway in Entamoeba histolytica: an overview Archives of Medical Research, 31, S151-S152.

Juarez,P. Sanchez-Lopez,R. Ramos,M.A. Stock,R.P. Alagon,A. 2000. Rab8 as a molecular model of vesicular trafficking to investigate the latter steps of the secretory pathway in Entamoeba histolytica Archives of Medical Research, 31, S157-S159.

Stock,R.P. Olvera,A. Scarfi,S. Sanchez,R. Ramos,M.A. Boffa,L.C. Benatti,U. Landt,O. Alagon,A. 2000. Inhibition of neomycin phosphorotransferase expression in Entamoeba histolytica with antisense peptide nucleic acid (PNA) oligomers Archives of Medical Research, 31, S271-S272.

Ramos,M.A. Stock,R.P. Lizardi,P.M. Alagon,A. 1997. The secretory pathway of Entamoeba histolytica: characterization and expression of the SRP54 gene.Archives of Medical Research, 28, 56-58.

Ramos,M.A. Stock,R.P. Sanchez-Lopez,R. Olvera,F. Lizardi,P.M. Alagon,A. 1997. The Entamoeba histolytica proteasome alpha-subunit gene Molecular and Biochemical Parasitology, 84, 131-135.

Moro,A. Ruiz-Cabello,F. Fernandez-Cano,A. Stock,R.P. Gonzalez,A. 1995. Secretion by Trypanosoma cruzi of a peptidyl-prolyl cis-trans isomerase involved in cell infection Embo Journal, 14, 2483-2490 * .

Garcia-Salcedo,J.A. Oliver,J.L. Stock,R.P. Gonzalez,A. 1994. Molecular characterization and transcription of the histone H2B gene from the protozoan parasite Trypanosoma cruzi Molecular Microbiology, 13, 1033-1043 * .

Libros y capítulos recientes

Chippaux,J.P. Stock,R.P. Massougbodji,A. 2017. Antivenom Safety and Tolerance for the Strategy of Snake Envenomation Management en: Rahmy,T.R. Snake Venoms. Dordrecht. Springer Netherlands. pags. 475-495

Chippaux,J.P. Stock,R.P. Massougbodji,A. 2015. Antivenom Safety and Tolerance for the Strategy of Snake Envenomation Management en: Vogel,C.W. Snake Venoms. Dordrecht. Springer Netherlands. pags. 1-16

Stock-Silberman,R.P. 2008. Biotecnología y antivenenos: el caso de África en: *agustin Una ventana al quehacer científico. Instituto de Biotecnología de la UNAM 25 aniversario, cap 28. Mexico, D.F.. UNAM. pags. 315-325

Divulgación

Chippaux,J.P. Diouf,A. Lam-Faye,A. Stock,R.P. Massougbodji,A. 2013. [Creation of the African Society of Toxinology.] Bulletin de la Societe de Pathologie Exotique, 106, 81-82.

Chippaux,J.P. Diouf,A. Massougbodji,A. Stock,R.P. Kane,O. Dieye,A.M. Lam-Faye,A. Mbaye,S.M. Parra,H.J. 2012. [Report of the 4th International Conference on Envenomations by Snakebites and Scorpion Stings in Africa, Dakar, April 25-29, 2011.] Bulletin de la Societe de Pathologie Exotique, 105, 194-198.

Chippaux,J.P. Diouf,A. Stock,R.P. Parra,H.J. Massougbodji,A. 2011. Report of the 4th international conference on envenomations by snakebites and scorpion stings in Africa, Dakar, April 25-29, 2011 Toxicon, 58, 426-429.

Rodriguez,M. Prud`Homme,M. Alagon,A. Stock,R. 2009. Expresión de a-latrotoxina Recombinante Activa de Latrodectus mactans Utilizando el Sistema de Células de Insecto-Baculovirus Biotecnologia, 13, 34-47.

Chippaux,J.P. Massougbodji,A. Stock,R. Akiana,J. Mokondjimobe,E. Parra,H.J. 2008. Report of the 3rd International Conference on Envenomations in Africa Bulletin de la Societe de Pathologie Exotique, 101, 437-438.

Stock,R.P. Massougbodji,A. Alagon,A. Chippaux,J.P. 2007. Bringing antivenoms to Sub-Saharan Africa Nature Biotechnology, 25, 173-177.

Chippaux,J.P. Stock,R.P. Alagon,A. 2005. Report of the 2nd international conference on envenomations in Africa (Deuxieme colloque international sur les envenomations en Afrique) Toxicon, 46, 115-118.

Stock,R. 2000. Comentario al libro El Raton, la mosca y el hombre de Francois Jacob.Biotecnologia, 5, 39-40.

Patentes

A. Olvera, R. P. Stock, B. M. Ramos, R. Sánchez y A. Alagón 2007 Inmunógeno y anti-veneno contra el veneno de la araña violinista.UNAM-Silanes Ecuador sp-07-7362, Australia 2005280742, Brasil PI0514809-0, Estados Unidos 11/574,488, Colombia 03082717, Costa Rica sin número y México MX/2007/002425. (en trámite)

A. Olvera, R. P. Stock, B. M. Ramos, R. Sánchez y A. Alagón 2007 Inmunógeno y anti-veneno contra el veneno de la araÒa violinista.UNAM-Silanes Ecuador, Australia, Brasil , Estados Unidos, Colombia y México. (en trámite)

A. Olvera, R. P. Stock, B. M. Ramos y A. Alagón 2005 Inmunógeno y anti-veneno contra el veneno de la araña violinista.Copropiedad de la UNAM-Silanes Perú.

A. Olvera, R. P. Stock, B. M. Ramos, R. Sánchez y A. Alagón 2005 Inmunógeno y anti-veneno contra el veneno de la araña violinista.UNAM-Silanes PCT, Nacionales en Chile 2223-05, Argentina P050103622 y Venezuela 2005-001775. (en trámite)

A. Olvera, R. P. Stock, B. M. Ramos y A. Alagón 2004 Inmunógeno y anti-veneno contra el veneno de la araña violinista.Copropiedad de la UNAM-Silanes México. (en trámite)

* Indica publicación con otra institución de adscripción